Abstract:
:A proper balance between oxidants and antioxidants is necessary in maintaining health and longevity. Alterations in this balance may result in oxidative stress causing functional disorders and diseases. Oxidative stress is considered to play a vital role in the pathogenesis of diabetes and its complications. Flavanones and flavanones-rich botanical extracts have been a subject of great interest for scientific research. Citrus flavanones like naringin and hesperidin exert a variety of biological activities such as anti-oxidant, anti-inflammatory, antihyperglycemic, anti-apoptotic etc. Naringin and hesperidin along with their respective aglycones, naringenin and hesperetin have been shown to attenuate diabetes and its related complications. This review discusses the role of flavanones as a possible emerging treatment for diabetes and its complications along with the possible mechanistic explanations.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Sharma M,Akhtar N,Sambhav K,Shete G,Bansal AK,Sharma SSdoi
10.2174/1568026615666141209163013subject
Has Abstractpub_date
2015-01-01 00:00:00pages
187-95issue
2eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-64218journal_volume
15pub_type
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