Abstract:
STUDY DESIGN:Prospective cross-sectional study. OBJECTIVE:To analyze the association of tomographically identified axial gouty lesions with clinical and laboratory characteristics. SUMMARY OF BACKGROUND DATA:Axial gout might be more common than previously thought. The true relationship of these lesions to symptoms or other gout-associated features is poorly understood. METHODS:Forty-two patients with gout underwent thoracic and lumbar spine computed tomographic (CT) scans. CT scans were read by an experienced radiologist blinded to the features of the patients. Axial gout was defined as the presence of bony erosions, facet joints, or disc calcification and tophi in the axial skeleton. Epidemiological and clinical data were collected from medical records. At study entry, patients were evaluated for axial symptoms (back pain or neurological complaints) and subcutaneous tophi. The Fisher exact test and the Student t test were performed for statistical analyses of data. RESULTS:Twelve (29%) of the 42 patients had CT evidence of axial gout. Axial tophi were identified in 5 patients (12%), interapophyseal joints erosions or calcifications in 7 patients (17%), and discal abnormalities in 9 patients (21%). Lumbar spine involvement was a universal finding. Five patients (42%) had thoracic spine involvement and 2 patients (18%) had sacroiliac lesions. No association was found between symptoms and axial gout (P = 0.62). Duration of gout, mechanism of disease (overproduction vs. underexcretion), and metabolic comorbidities were not related to axial involvement. A higher prevalence of axial gout was found between patients with current peripheral tophi (67% vs. 30%; P = 0.03); however, no association was found in patients with a past history of tophi (P = 0.72). CONCLUSION:Our study demonstrated a high prevalence of axial gout not associated with spine symptoms. This finding introduces a differential diagnosis in axial lesions in patients with gout. In addition, the unique association with a current but not previous history of peripheral tophi suggests that gout treatment might be effective in preventing or solving gout axial lesions. LEVEL OF EVIDENCE:3.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
de Mello FM,Helito PV,Bordalo-Rodrigues M,Fuller R,Halpern ASdoi
10.1097/BRS.0000000000000633subject
Has Abstractpub_date
2014-12-01 00:00:00pages
E1531-6issue
25eissn
0362-2436issn
1528-1159journal_volume
39pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:Scoliosis patients were prospectively x-rayed in three positions with independent analysis. OBJECTIVES:To determine if one positioning technique provides superior visualization of critical landmarks (C7, T2, T12, L5-S1) and to determine any position dependent variations in regional measures or sagittal ba...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000153698.94091.f8
更新日期:2005-02-15 00:00:00
abstract:STUDY DESIGN:Case-control study. OBJECTIVE:To identify laboratory markers for surgical site infection (SSI) in posterior lumbar decompression surgery, which are not affected by operative factors, and to determine the diagnostic cutoffs of these markers. SUMMARY OF BACKGROUND DATA:Numerous laboratory markers are used ...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000002617
更新日期:2018-09-15 00:00:00
abstract:STUDY DESIGN:This cohort study compares motion characteristics during forward bending of a group of chronic female patients either with low back pain (LBP) or pelvic girdle pain (PGP) and healthy subjects using computer-video analysis. OBJECTIVE:This study determines whether subcategories of back pain patients could b...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318170fcf6
更新日期:2008-05-15 00:00:00
abstract:STUDY DESIGN:Conditioned media (CM) of cartilaginous endplates (CEPs) of intervertebral discs were analyzed in a bioassay with regard to their influence on matrix turnover and inflammatory factors on nucleus pulposus (NP) cells of the same patient. CEP tissue underwent further histological and ultrastructural analysis....
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000372
更新日期:2014-08-01 00:00:00
abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:To determine the perioperative complications for patients undergoing single stage, multilevel, anterior, and posterior cervical fusions crossing the cervico-thoracic junction. SUMMARY OF BACKGROUND DATA:Cervical spinal stenosis with kyphosis involving 3 or more disc levels...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318190affe
更新日期:2008-12-15 00:00:00
abstract::A retrospective review of the treatment of chronic back and extremity pain is presented. Laminectomy is most effective for pain secondary to direct compression of the neural elements. Treatment of pseudoradicular pain requires identification of the source of pain input. Facet rhizotomy is specific for pain arising fro...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197903000-00009
更新日期:1979-03-01 00:00:00
abstract:STUDY DESIGN:Multicenter, prospective analysis of consecutive patients with adult spinal deformity (ASD). OBJECTIVE:Identify age-related radiographical parameters associated with poor health-related quality of life (HRQOL) and treatment preferences for ASD. SUMMARY OF BACKGROUND DATA:Patients with ASD report discrepa...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000414
更新日期:2014-08-01 00:00:00
abstract:STUDY DESIGN:A retrospective review was conducted covering records of patients who underwent spinal surgery after acute spinal cord injury. OBJECTIVE:To study the relation between time of operation and mobilization of patients. SUMMARY OF BACKGROUND DATA:No such report has existed in the literature. METHODS:Reviews ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200110150-00022
更新日期:2001-10-15 00:00:00
abstract::Degenerative lumbar spondylolisthesis associated with spinal stenosis is a common condition of the aging spine. This article presents a detailed description of the pathophysiology, clinical presentation, and nonoperative and operative intervention of this condition. ...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-199505000-00018
更新日期:1995-05-01 00:00:00
abstract:STUDY DESIGN:Retrospective analysis of prospectively acquired data. OBJECTIVE:To identify interaction effects that modulate nonhome discharge (NHD) risk by applying coalitional game theory principles to interpret machine learning models and understand variable interaction effects underlying NHD risk. SUMMARY OF BACKG...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003910
更新日期:2020-12-28 00:00:00
abstract:STUDY DESIGN:A case report of traumatic atlantooccipital dislocation (AOD) managed by intraarticular-posterior fusion from a posterior approach at the C0-C1 level with preservation of C1-C2 motion. OBJECTIVE:To present a new technique for atlantooccipital fusion with long-term follow-up. SUMMARY OF BACKGROUND DATA:Th...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181c91fa1
更新日期:2010-05-01 00:00:00
abstract::Correct dermatome identification is essential to reduce nomenclature and surgical errors, to improve neurologic correlation, and to produce accurate statistics regarding low-back problems. The phylogenetic category of the spine must be known and junctional transitional vertebrae within the column properly identified a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198005000-00003
更新日期:1980-05-01 00:00:00
abstract:STUDY DESIGN:Finite element and in vitro study. OBJECTIVE:Finite element calculations to delineate a dynamic fixator and confirmation with an in vitro experiment. SUMMARY AND BACKGROUND DATA:In the last few years, there was a paradigm shift from rigid to dynamic fixation of spinal segments. However, some so-called dy...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181920e9c
更新日期:2009-02-01 00:00:00
abstract:STUDY DESIGN:This was a subanalysis of an international, multicenter, open-label study. OBJECTIVE:The aim of this study was to assess the efficacy and safety of denosumab in a subset of patients with giant cell tumors of bone (GCTB) of the spine including the sacrum from an international, open-label, single-arm, phase...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003728
更新日期:2020-10-08 00:00:00
abstract:STUDY DESIGN:A case report with a review of the literature. OBJECTIVES:Anterior cervical spine surgery (ACS) has received widespread acceptance, and as a result, a variety of complications have been reported. Several cases of esophageal complications, arising from the use of various implants and grafts, have been desc...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318074d56c
更新日期:2007-07-01 00:00:00
abstract:STUDY DESIGN:Comparvative case series. Data was prospectively entered and retrospectively analyzed. OBJECTIVE:To evaluate the need for distal lumbar interbody fusion when sufficient recombinant human bone morphogenetic protein-2 (rhBMP-2) is used posterolaterally at L5-S1 in long spinal constructs for adult deformity ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000045
更新日期:2013-12-15 00:00:00
abstract:STUDY DESIGN:In vivo, canine lumbar spine intervertebral motion was measured before and after instrumentation of caudal segments. The three-dimensional kinematics of the intervertebral joint were described using helical axes and Fourier series. OBJECTIVE:The in vivo three-dimensional kinematics of the intervertebral j...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:STUDY DESIGN:A retrospective case series. OBJECTIVE:The aim of this study was to evaluate patients with cervical spine osteomyelitis who underwent multilevel (≥2) subaxial corpectomies and anterior column reconstruction and plating. SUMMARY OF BACKGROUND DATA:Neglected multilevel subaxial cervical osteomyelitis is a ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001557
更新日期:2016-09-15 00:00:00
abstract:STUDY DESIGN:Retrospective analysis of prospectively collected multicenter series. OBJECTIVE:To evaluate the sagittal profile of surgically treated adolescent idiopathic scoliosis (AIS) patients. SUMMARY OF BACKGROUND DATA:With the increasing popularity of segmental pedicle screw spinal instrumentation, thoracic kyph...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181dccd63
更新日期:2010-06-15 00:00:00
abstract:STUDY DESIGN:Analysis of clinical database material collected prospectively. OBJECTIVE:Examination of the association between lateralization of scoliotic curves and the existence of underlying disease. SUMMARY OF BACKGROUND DATA:It has been suggested that left thoracic scoliosis configurations are intrinsically patho...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199906150-00010
更新日期:1999-06-15 00:00:00
abstract::Over a 2-year period, 92 patients were submitted as outpatients to lumbar myelography using lopamidol, a new nonionic water-soluble contrast medium. The incidence and severity of adverse reactions associated with myelography in these cases were compared with those in 116 patients who underwent lopamidol myelography as...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1985-07-01 00:00:00
abstract:STUDY DESIGN:Longitudinal prospective study on a sample of 41 consecutive disc prosthesis patients, covering a postoperative time period of at least 2 years. OBJECTIVES:To document the rotational and translational range of segmental motion of patients instrumented with ProDisc II prostheses in the lumbar spine and to ...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/01.brs.0000224213.45330.68
更新日期:2006-07-01 00:00:00
abstract:STUDY DESIGN:A prospective cohort design was used to evaluate the Functional Rating Index in a multicentered setting with 139 participants. The Functional Rating Index is a self-reporting instrument consisting of 10 items, each with 5 possible responses that express graduating degrees of disability. OBJECTIVES:The goa...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/00007632-200101010-00015
更新日期:2001-01-01 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:The authors aim to review comparative outcome measures between robotic and free-hand spine surgical procedures including: accuracy of spinal instrumentation, radiation exposure, operative time, hospital stay, and complication rates. SUMMARY OF BACKGROUND DATA:Misplacement of ...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000002695
更新日期:2018-12-01 00:00:00
abstract:STUDY DESIGN:A retrospective study of patient outcomes after decompression and fusion for degenerative spondylolisthesis, using the SF-36 survey and a functional questionnaire. SUMMARY OF BACKGROUND DATA:In recent studies, patient outcomes have been examined more specifically; however, detailed functional outcomes are...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199903150-00012
更新日期:1999-03-15 00:00:00
abstract:STUDY DESIGN:Retrospective radiographical study. OBJECTIVE:To compare the sex differences in curve patterns and radiographical characteristics in patients who have adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA:Sex differences in AIS have been documented in the incidence of curve progression, respo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182511d0c
更新日期:2012-08-15 00:00:00
abstract:STUDY DESIGN:A case report is described. OBJECTIVE:To describe the very rare complication of destroyed lung syndrome after scoliosis correction. SUMMARY OF BACKGROUND DATA:The destroyed lung syndrome has, to our knowledge, never been associated with scoliosis in the literature. Bronchial kinking and compression by th...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200207150-00021
更新日期:2002-07-15 00:00:00
abstract::An electronic bone growth stimulator (EBGS) had been devised to facilitate lumbosacral fusion in the early 1970s, using a totally implanted device which delivers a steady 5 microA at each of four cathodes. The use of the device is reserved for patients in whom painful and abnormal motion is demonstrated to be the majo...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-198803000-00026
更新日期:1988-03-01 00:00:00
abstract:STUDY DESIGN:A cross-sectional study. OBJECTIVE:To identify facet tropism as one of the possible risk factors leading to vertebral rotatory subluxation (VRS). SUMMARY OF BACKGROUND DATA:VRS has been considered as one of the prognostic factors for degenerative scoliosis. Although several risk factors of VRS, including...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000494
更新日期:2014-12-15 00:00:00
abstract::The authors observed six cases of chylothorax of 2,000 operations for spinal deformities performed in the past 5 years: in one case of VDS, two Harrington operations, and three anterior strut graft operations. Chylothorax resulted from direct injury to the lymphatic system in four cases of anterior spinal surgery. One...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198610000-00018
更新日期:1986-10-01 00:00:00