Abstract:
STUDY DESIGN:Case-control study. OBJECTIVE:To identify laboratory markers for surgical site infection (SSI) in posterior lumbar decompression surgery, which are not affected by operative factors, and to determine the diagnostic cutoffs of these markers. SUMMARY OF BACKGROUND DATA:Numerous laboratory markers are used for the early detection of SSI; however, these markers may be affected by operative factors. METHODS:The study included 182 participants. They were divided into an SSI group (patients who developed deep SSI; n = 8) and a no-SSI group (n = 174). We reviewed data on the C-reactive protein level and total white blood cell count and differential count before posterior lumbar decompression surgery and 1 and 4 days postoperatively. We determined which markers differed significantly between the groups and identified the markers that were not affected by operative factors (operative time, intraoperative blood loss, and number of operative segments) in the no-SSI group. We then determined the diagnostic cutoffs of these unaffected markers using receiver operating characteristic curves. RESULTS:We identified the lymphocyte percentage at 4 days postoperatively (cutoff, <19.4%; sensitivity, 80.0%; specificity, 62.5%; area under the curve, 0.78) and lymphocyte count at 4 days postoperatively (cutoff, <1010/μL; sensitivity, 93.7%; specificity, 62.5%; area under the curve, 0.78) as reliable markers. CONCLUSION:Lymphocyte percentage and count at 4 days postoperatively are reliable markers for SSI after posterior lumbar decompression surgery. Lymphocyte count at 4 days postoperatively can be considered as a superior marker for screening because it has a high sensitivity and can be measured early. LEVEL OF EVIDENCE:4.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Iwata E,Shigematsu H,Yamamoto Y,Tanaka M,Okuda A,Morimoto Y,Masuda K,Nakajima H,Koizumi M,Tanaka Ydoi
10.1097/BRS.0000000000002617subject
Has Abstractpub_date
2018-09-15 00:00:00pages
E1096-E1101issue
18eissn
0362-2436issn
1528-1159pii
00007632-201809150-00015journal_volume
43pub_type
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