Establishing a successful clinical research program.

Abstract:

:Clinical research (CR) is a natural corollary to clinical surgery. It gives an investigator the opportunity to critically review their results and develop new strategies. This article covers the critical factors and the important components of a successful CR program. The first and most important step is to build a dedicated research team to overcome time constraints and enable a surgical practice to make CR a priority. With the research team in place, the next step is to create a program on the basis of an original idea and new clinical hypotheses. This often comes from personal experience supported by a review of the available evidence. Randomized controlled (clinical) trials are the most stringent way of determining whether a cause-effect relationship exists between the intervention and the outcome. In the proper setting, translational research may offer additional avenues allowing clinical application of basic science discoveries.

journal_name

Clin Colon Rectal Surg

authors

Scoglio D,Fichera A

doi

10.1055/s-0034-1376171

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

65-70

issue

2

eissn

1531-0043

issn

1530-9681

pii

00641

journal_volume

27

pub_type

杂志文章,评审
  • Evidence-based medicine in surgical education.

    abstract::Evidence-based medicine (EBM) is increasingly important for clinical surgery and for promotion of best practices into surgical decision making. Although barriers exist in the current surgical literature, for certain surgical scenarios, formal efforts to promote evidence-based surgery (EBS) into surgical education are ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0032-1322552

    authors: Kwaan MR,Melton GB

    更新日期:2012-09-01 00:00:00

  • Parasitic colitides.

    abstract::Parasitic infections are a major worldwide health problem, and they account for millions of infections and deaths each year. Most of the infections as well as the morbidity and mortality from these diseases occur in the developing world in rural regions. However, these diseases have become more common in Western count...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-970199

    authors: Goldberg JE

    更新日期:2007-02-01 00:00:00

  • The Role of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Appendiceal Tumors and Colorectal Adenocarcinomas.

    abstract::Peritoneal surface disease (PSD) has historically been used interchangeably with the term peritoneal carcinomatosis (PC) and has a dismal natural history. A variety of malignant pathologies, including colorectal and appendiceal primary tumors, can disseminate throughout the peritoneal cavity, leading to bowel obstruct...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1642052

    authors: Kuncewitch M,Levine EA,Shen P,Votanopoulos KI

    更新日期:2018-09-01 00:00:00

  • ISR for T1-2 Low Rectal Cancer: A Japanese Approach.

    abstract::The evolution over the past 20 years of anal preservation in rectal cancer surgery has been truly remarkable. Intersphincteric resection (ISR) reported by Schiessel in 1994 in Australia has been shown to enable anal preservation even for cancers quite close to the anus. In Japan, ISR via the detachment of the anal can...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0040-1714240

    authors: Ito M

    更新日期:2020-11-01 00:00:00

  • Abdominal wall reconstruction in patients with digestive tract fistulas.

    abstract::Abdominal wall reconstruction in the digestive tract fistula patient is a complex issue. The authors review the available data and present information regarding the timing of surgery, techniques of abdominal wall reconstruction, hernia repair, and discuss pitfalls associated with the various options. A simple and basi...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0030-1262988

    authors: Johnson EK,Tushoski PL

    更新日期:2010-09-01 00:00:00

  • Role of professional societies in career development.

    abstract::Professional medical societies serve several functions that may benefit society, the sponsoring medical profession, and individual members. Several professional societies are available for colorectal surgeons to join and participate in. Reasons to join include service, educational offerings, networking, and companions...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1278406

    authors: Beck DE

    更新日期:2011-06-01 00:00:00

  • Intestinal Intussusception: Etiology, Diagnosis, and Treatment.

    abstract::Intussusception is defined as the invagination of one segment of the bowel into an immediately adjacent segment of the bowel. Idiopathic ileocolic intussusception is the most common form in children and is typically managed with nonoperative reduction via pneumatic and/or hydrostatic enemas. In the adult population, i...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1593429

    authors: Marsicovetere P,Ivatury SJ,White B,Holubar SD

    更新日期:2017-02-01 00:00:00

  • Perineal wound complications after abdominoperineal resection.

    abstract::Perineal wound complications following abdominoperineal resection (APR) is a common occurrence. Risk factors such as operative technique, preoperative radiation therapy, and indication for surgery (i.e., rectal cancer, anal cancer, or inflammatory bowel disease [IBD]) are strong predictors of these complications. Pati...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055325

    authors: Wiatrek RL,Thomas JS,Papaconstantinou HT

    更新日期:2008-02-01 00:00:00

  • Postoperative Complications: Looking Forward to a Safer Future.

    abstract::Colorectal surgery patients frequently suffer from postoperative complications. Patients with complications have been shown to be at higher risk for mortality, poor oncologic outcomes, additional complications, and worse quality of life. Complications are increasingly recognized as markers of quality of care with more...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1584501

    authors: Tevis SE,Kennedy GD

    更新日期:2016-09-01 00:00:00

  • Future Directions.

    abstract::Transanal total mesorectal excision (taTME) is a novel technique that has evolved over the years to address the challenges of low rectal cancer surgery by applying the principles and benefits of laparoscopic surgery to more historic transanal techniques. It has been popularized through its use in rectal cancer, but th...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-3402781

    authors: Soares AS,Chand M

    更新日期:2020-05-01 00:00:00

  • Paradoxical puborectalis contraction and increased perineal descent.

    abstract::Paradoxical puborectalis contraction and increased perineal descent are two forms of functional constipation presenting as challenging diagnostic and treatment dilemmas to the clinician. In the evaluation of these disorders, the clinician should take special care to exclude anatomic disorders leading to constipation. ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1075863

    authors: Landmann RG,Wexner SD

    更新日期:2008-05-01 00:00:00

  • Techniques in total mesorectal excision surgery.

    abstract::Advances in the surgical management of rectal cancer have placed the quality of total mesorectal excision (TME) as the major predictor in overall survival. A standardized TME technique along with quality increases the percentage of patients undergoing a complete TME. Quality measurements of TME will place increasing d...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1545066

    authors: Lichliter WE

    更新日期:2015-03-01 00:00:00

  • Laparoscopy for Colon Cancer.

    abstract::The use of laparoscopy has become widespread across many surgical specialties. Its utility as treatment for colon cancer was initially met with hesitancy due to concern for port site and wound recurrences; however, this was later disproven by large retrospective series. Subsequently, there have been multiple, large, p...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1597317

    authors: Franklin BR,McNally MP

    更新日期:2017-04-01 00:00:00

  • Medical treatment of ulcerative colitis.

    abstract::Ulcerative colitis is a chronic inflammatory disease of the colon with an increasing incidence worldwide. The medical management of this disease continues to expand as drugs to induce and maintain remission are sought to avoid the need for colectomy. This article will review the standard of care for the treatment of m...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-823066

    authors: Mahadevan U

    更新日期:2004-02-01 00:00:00

  • Pediatric Crohn's Disease.

    abstract::The incidence of Crohn's disease in the pediatric population is increasing. While pediatric patients with Crohn's disease exhibit many of the characteristics of older patients, there are important differences in the clinical presentation and course of disease that can impact the clinical decisions made during treatmen...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1609022

    authors: von Allmen D

    更新日期:2018-03-01 00:00:00

  • Is There Any Reason to Still Consider Lateral Lymph Node Dissection in Rectal Cancer? Rationale and Technique.

    abstract::Nodal dissemination in locally advanced rectal cancer occurs mainly in two directions: upward and lateral. Lateral node involvement has been demonstrated; however, lateral lymph node dissection (LLND) is not routinely performed in Western countries and the focus is more on neoadjuvant treatment regimens. The main reas...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1606112

    authors: Kusters M,Uehara K,Velde CJHV,Moriya Y

    更新日期:2017-11-01 00:00:00

  • Laparoscopic colectomy for colon cancer: comparable to conventional oncologic surgery?

    abstract::As a result of the obvious benefits of laparoscopic cholecystectomy, minimally invasive techniques have been applied to more complex gastrointestinal procedures, including colorectal resections. The goal in adapting laparoscopic techniques for colorectal surgery is to offer an operation that results in less pain, shor...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2005-916278

    authors: Bonnor RM,Ludwig KA

    更新日期:2005-08-01 00:00:00

  • Inherited colorectal cancer syndromes.

    abstract::Colorectal cancer is common in the Western world; ~5% of individuals diagnosed with colorectal cancer have an identifiable inherited genetic predisposition to this malignancy. Genetic testing and rational clinical management recommendations currently exist for the management of individuals with a variety of colorectal...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0029-1242459

    authors: Gryfe R

    更新日期:2009-11-01 00:00:00

  • Types of Leadership and How to Use Them in Surgical Areas.

    abstract::Surgery is a very complex, changing, and, sometimes, threatening environment. Emotional intelligence is a key skill for surgical leaders. Authoritarian, hierarchical, transactional, transformational, adaptive, situational, and servant-shepherd leadership can all be used in surgical leadership. Patient care must be the...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0040-1709457

    authors: Onaca N,Fleshman JW

    更新日期:2020-07-01 00:00:00

  • Colonic Polyps: Diagnosis and Surveillance.

    abstract::Colorectal cancer begins as a polyp that is a benign growth on the mucosal surface of the colon or rectum. Over a period of 5 to 15 years, polyps can degenerate into a cancer, thus invading the colonic wall. Colorectal screening methods are designed to diagnose and remove polyps before they acquire invasive potential ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1584091

    authors: Huck MB,Bohl JL

    更新日期:2016-12-01 00:00:00

  • Muscle transposition: does it still have a role?

    abstract::Since the early 1900s, skeletal muscle transpositions have been employed for complicated cases of fecal incontinence to augment or replace the anal sphincter. Multiple techniques have evolved that vary with the type and configuration of muscle used in the reconstruction. Transposition of the gluteus maximus muscle was...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2005-864081

    authors: Cera SM,Wexner SD

    更新日期:2005-02-01 00:00:00

  • Obstetrics and fecal incontinence.

    abstract::Anal incontinence (AI) can be a debilitating condition for women following vaginal delivery. Operative vaginal delivery and anal sphincter laceration are important risk factors for the development of postpartum AI. Obtaining a comprehensive delivery history, along with a thorough physical examination of the perineum, ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1383903

    authors: Chin K

    更新日期:2014-09-01 00:00:00

  • Surgical hemorrhage, damage control, and the abdominal compartment syndrome.

    abstract::The morbidity and mortality associated with surgical hemorrhage are considerable, particularly when relaparotomy is necessary. This complication can usually be avoided with comprehensive preoperative patient evaluation and meticulous surgical technique. The damage control sequence is a useful surgical strategy when se...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-956439

    authors: Hammond KL,Margolin DA

    更新日期:2006-11-01 00:00:00

  • Mentorship.

    abstract::The world of medicine is in a state of flux with major and substantive changes in its educational model. Students, residents, and junior attendings can no longer rely entirely on experiential development through clinical immersion. Instead, to attain similar levels of knowledge, technique, and situational comfort, the...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1356720

    authors: Platz J,Hyman N

    更新日期:2013-12-01 00:00:00

  • Management of colonic obstruction: a review.

    abstract::Large bowel obstruction is a common problem with many different causes, the most common being colorectal adenocarcinoma, extracolonic adenocarcinoma, diverticular disease, volvulus, and inflammatory bowel disease. The nature of the obstruction can influence the best management. Historically, treatment of obstruction c...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1329533

    authors: Sawai RS

    更新日期:2012-12-01 00:00:00

  • Locally Advanced Disease and Pelvic Exenterations.

    abstract::Advanced primary and recurrent colorectal cancer can be successfully treated by experienced, dedicated centers delivering good outcomes with low mortality and morbidity. Development and implementation of a comprehensive referral pathway is to be encouraged. Multidisciplinary team management is essential in the managem...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1606118

    authors: Kontovounisios C,Tekkis P

    更新日期:2017-11-01 00:00:00

  • Computed tomography colonography (virtual colonoscopy): climax of a new era of validation and transition into community practice.

    abstract::Colorectal cancer, which kills more than 50,000 patients every year in the United States and costs more than $6 billion in direct health costs, is a prime target for cancer prevention. Computed tomography colonography (CTC) has emerged as a minimally invasive, structural examination of the entire colon that can comple...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1081001

    authors: Thomas J,Carenza J,McFarland E

    更新日期:2008-08-01 00:00:00

  • Colorectal lymphoma.

    abstract::Lymphoma involving the colon and rectum is rare and can occur either as primary colorectal lymphoma or as a manifestation of systemic disease. Most patients with primary colorectal lymphoma present with abdominal pain, and obstruction is unusual. Although lesions may be evident on radiographic studies, the findings ar...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-942344

    authors: Quayle FJ,Lowney JK

    更新日期:2006-05-01 00:00:00

  • Multispecialty clinic practice.

    abstract::A multispecialty clinic practice is a common practice arrangement for colorectal surgeons. A practice of this type has a variety of features, both positive and negative. This article explores the location, practice patterns, lifestyles, compensation, and academic opportunities associated with a multispecialty clinic p...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-948023

    authors: Beck DE,Margolin DA

    更新日期:2006-08-01 00:00:00

  • Participation in quality measurement nationwide.

    abstract::In the interest of improving patient care quality and reducing costs, many hospitals across the nation participate in quality measurements. The three programs most applicable to colon and rectal surgery are the National Surgical Quality Improvement Project, the Surgical Care Improvement Project (SCIP), and the Surgica...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1366914

    authors: Irani JL

    更新日期:2014-03-01 00:00:00