Abstract：
BACKGROUND:Renal abnormalities are often seen in sickle cell disease (SCD). OBJECTIVE:To investigate the role of hydroxycarbamide as a protective agent in sickle cell nephropathy. SETTING:Patients with SCD followed at a Hematology outpatients clinic. METHODS:Prospective study with 26 SCD patients. Renal function evaluation was performed and a comparison between patients and control group was done. Patients using hydroxycarbamide were compared to those not taking this drug. MAIN OUTCOME MEASURE:Effect of hydroxycarbamide on renal function. RESULTS:Patients mean age was 32.1 ± 9.9 years, and 16 (61 %) were males. Glomerular hyperfiltration was found in nine patients with SCD (34.6 %). GFR < 60 mL/min/1.73 m² was observed in three cases (11.5 %). Microalbuminuria (30-300 mg/day) was found in seven cases (27 %) and macroalbuminuria (>300 mg/dia) in one patient (3.8 %). All patients had urinary concentrating deficit, and inability to acidify urine was found in ten cases (38.4 %). The comparison of patients according to the use of hydroxycarbamide showed lower levels of serum creatinine in those using the drug (0.6 ± 0.1 vs. 0.8 ± 0.3 mg/dL, p = 0.03), as well as lower levels of 24 h-proteinuria (226 ± 16 vs. 414 ± 76 mg/dL, p = 0.0001), but not microalbuminuria (79 ± 15 vs. 55 ± 86 mg/dL, p = 0.35). CONCLUSION:SCD is associated with important renal abnormalities. Hydroxycarbamide seems to protect kidney function in SCD by decreasing proteinuria but not microalbuminuria.
journal_name
Int J Clin Pharmjournal_title
International journal of clinical pharmacyauthors
Silva Junior GB,Vieira AP,Couto Bem AX,Alves MP,Meneses GC,Martins AM,Araújo SM,Libório AV,Daher EFdoi
10.1007/s11096-014-9955-4subject
Has Abstractpub_date
2014-08-01 00:00:00pages
766-70issue
4eissn
2210-7703issn
2210-7711journal_volume
36pub_type
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更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章,多中心研究
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