Invasive bacterial and fungal infections in paediatric patients with cancer: incidence, risk factors, aetiology and outcomes in a UK regional cohort 2009-2011.

abstract：:Nutrition therapy is a therapeutic approach to treating medical conditions and symptoms via diet, which can be done by oral, enteral or parenteral routes. It is desirable to include nutritional interventions as a standard of care in pediatric cancer units (PCUs) at all levels of care. The interventions are dependent o...

journal_title：Pediatric blood & cancer

authors： Trehan A,Viani K,da Cruz LB,Sagastizado SZ,Ladas EJ

更新日期：2020-06-01 00:00:00

abstract：:Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Chil...

journal_title：Pediatric blood & cancer

authors： Verbruggen LC,Wang Y,Armenian SH,Ehrhardt MJ,van der Pal HJH,van Dalen EC,van As JW,Bardi E,Baust K,Berger C,Castagnola E,Devine KA,Gebauer J,Marchak JG,Glaser AW,Groll AH,Haeusler GM,den Hartogh J,Haupt R,Hjorth L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The prognostic significance of having extraskeletal (EES) versus skeletal Ewing sarcoma (ES) in the setting of modern chemotherapy protocols is unknown. The purpose of this study was to compare the clinical characteristics, biologic features, and outcomes for patients with EES and skeletal ES. METHODS:Patie...

journal_title：Pediatric blood & cancer

authors： Cash T,McIlvaine E,Krailo MD,Lessnick SL,Lawlor ER,Laack N,Sorger J,Marina N,Grier HE,Granowetter L,Womer RB,DuBois SG

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The identification of tissue-specific differentially methylated regions (tDMRs) is key to our understanding of mammalian development. Research has indicated that tDMRs are aberrantly methylated in cancer and may affect the oncogenic process. PROCEDURE:We used the MassARRAY EpiTYPER system to determine the q...

journal_title：Pediatric blood & cancer

authors： Sugito K,Kawashima H,Uekusa S,Yoshizawa S,Hoshi R,Furuya T,Kaneda H,Hosoda T,Masuko T,Ohashi K,Ikeda T,Koshinaga T,Fujiwara K,Igarashi J,Ghosh S,Held WA,Nagase H

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Few studies have evaluated social determinants of outcomes disparities for children with acute lymphoblastic leukemia (ALL). We investigated the association of area deprivation index (ADI), a measure of neighborhood socioeconomic disadvantage, with overall survival (OS) among children and adolescents with AL...

journal_title：Pediatric blood & cancer

authors： Schraw JM,Peckham-Gregory EC,Rabin KR,Scheurer ME,Lupo PJ,Oluyomi A

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Hematopoietic stem cell transplant (HSCT) can cure or alleviate a wide range of nonmalignant childhood conditions. However, few studies have examined longitudinal national trends of frequency or short-term complications of HSCT before 2006 when an HSCT became a reportable procedure by US law. By using a US n...

journal_title：Pediatric blood & cancer

authors： Takahashi T,Pereda MA,Bala N,Nagarajan S

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The optimal dose and schedule of mycophenolate mofetil (MMF) in pediatric allogeneic stem cell transplant recipients remains to be determined. We previously reported safety and pharmacokinetics of MMF at 900 mg/m2 q6h dosing. This study was conducted to investigate the efficacy of tacrolimus plus q8h MMF dos...

journal_title：Pediatric blood & cancer

authors： Militano O,Ozkaynak MF,Mehta B,van deVen C,Hamby C,Cairo MS

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Although genetic and environmental factors are considered to be the main causes of acute lymphoblastic leukemia, the associations between maternal factors during pregnancy and the childhood ALL is still unclear. PROCEDURE:In this study, meta-analysis was used. Medline, PubMed, and Web of Science were search...

journal_title：Pediatric blood & cancer

authors： Yan K,Xu X,Liu X,Wang X,Hua S,Wang C,Liu X

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Prophylactic use of cranial radiation therapy (CRT) in young children with acute lymphoblastic leukemia (ALL) is associated with significant long-term morbidity. Therefore, current treatment protocols for pediatric B-precursor ALL have abandoned prophylactic CRT in favor of intrathecal chemotherapy, combined...

journal_title：Pediatric blood & cancer

authors： Nathan PC,Maze R,Spiegler B,Greenberg ML,Weitzman S,Hitzler JK

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Treatment intensification was considered a suitable strategy to increase the cure rate of lymphoblastic lymphoma (LBL) in children. PROCEDURE:The AIEOP LNH-97 trial was run between 1997 and 2007 for newly diagnosed LBL in patients aged less than 18 years. Treatment schedule was based on the previous, LSA2-L...

journal_title：Pediatric blood & cancer

authors： Pillon M,Aricò M,Mussolin L,Carraro E,Conter V,Sala A,Buffardi S,Garaventa A,D'Angelo P,Lo Nigro L,Santoro N,Piglione M,Lombardi A,Porta F,Cesaro S,Moleti ML,Casale F,Mura R,d'Amore ES,Basso G,Rosolen A

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the value of follow-up investigations of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell non-Hodgkin's lymphoma (T-NHL), including cerebrospinal fluid (CSF) examination, bone marrow (BM) aspiration, peripheral blood (PB) count, serum lactate dehydrogenase (LDH) an...

journal_title：Pediatric blood & cancer

authors： Huang L,Lequin M,Pieters R,van den Heuvel-Eibrink MM

更新日期：2007-04-01 00:00:00

abstract：:Opportunities for cancer prevention in adolescents range from limitation of sun exposure to the use of human papillomavirus vaccines. Those who develop malignant disease experience longer waiting times for diagnosis and treatment than do children, especially when referred to adult treatment centers, and they are less ...

journal_title：Pediatric blood & cancer

authors： Barr RD,Greenberg ML

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. PROCEDURE:Children underwent cardiopulmonary exercise testi...

journal_title：Pediatric blood & cancer

authors： Vandekerckhove K,De Waele K,Minne A,Coomans I,De Groote K,Panzer J,Dhooge C,Bordon V,De Wolf D,Boone J

更新日期：2019-01-01 00:00:00

abstract：:The majority of children with cancer live in low- and middle-income countries (LMICs) with little or no access to cancer treatment. The purpose of the paper is to describe the current status of childhood cancer treatment in Africa, as documented in publications, dedicated websites and information collected through sur...

journal_title：Pediatric blood & cancer

authors： Kruger M,Hendricks M,Davidson A,Stefan CD,van Eyssen AL,Uys R,van Zyl A,Hesseling P

更新日期：2014-04-01 00:00:00

abstract：:Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...

journal_title：Pediatric blood & cancer

authors： Barr RD,Antillón Klussmann F,Baez F,Bonilla M,Moreno B,Navarrete M,Nieves R,Peña A,Conter V,De Alarcón P,Howard SC,Ribeiro RC,Rodriguez-Galindo C,Valsecchi MG,Biondi A,Velez G,Tognoni G,Cavalli F,Masera G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Opioids are a cornerstone of palliation of pain. We sought to assess variation in opioid prescription during the last week of life among a cohort of pediatric oncology patients who died while hospitalized. PROCEDURE:We used detailed hospital administrative data from the Pediatric Health Information System (...

journal_title：Pediatric blood & cancer

authors： Orsey AD,Belasco JB,Ellenberg JH,Schmitz KH,Feudtner C

更新日期：2009-07-01 00:00:00

abstract：:Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (S...

journal_title：Pediatric blood & cancer

authors： Martinez-Borges AR,Petty JK,Hurt G,Stribling JT,Press JZ,Castellino SM

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:We assessed the safety and efficacy of ifosfamide and vinorelbine (IV) as a less toxic and effective reinduction regimen for pediatric patients with relapsed or refractory Hodgkin Lymphoma. PROCEDURE:This multi-center Children's Oncology Group phase II pilot study enrolled patients <30 years of age with bio...

journal_title：Pediatric blood & cancer

authors： Trippett TM,Schwartz CL,Guillerman RP,Gamis AS,Gardner S,Hogan S,London WB,Chen L,de Alarcon P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:A total of 201 pediatric cases of acute lymphoblastic leukemia were treated with the ALL-96 protocol by the Kyushu-Yamaguchi Children's Cancer Study Group. PROCEDURE:Risk stratification was based on white cell counts, immunophenotype, the presence of central nervous system disease at diagnosis, organomegaly...

journal_title：Pediatric blood & cancer

authors： Nagatoshi Y,Matsuzaki A,Suminoe A,Inada H,Ueda K,Kawakami K,Yanai F,Nakayama H,Moritake H,Itonaga N,Hotta N,Fujita K,Hidaka Y,Yamanaka T,Kawano Y,Okamura J

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Although chemotherapy has improved outcome of osteosarcoma, 30-40% of patients succumb to this disease. Survivors experience substantial morbidity and mortality from anthracycline-induced cardiotoxicity. We hypothesized that the cardioprotectant dexrazoxane would (i) support escalation of the cumulative doxo...

journal_title：Pediatric blood & cancer

authors： Schwartz CL,Wexler LH,Krailo MD,Teot LA,Devidas M,Steinherz LJ,Goorin AM,Gebhardt MC,Healey JH,Sato JK,Meyers PA,Grier HE,Bernstein ML,Lipshultz SE

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:To evaluate efficacy, pharmacokinetics (PK) and pharmacodynamics of single-agent everolimus in pediatric patients with radiographically progressive low-grade glioma (LGG). METHODS:Everolimus was administered at 5 mg/m2 once daily as a tablet or liquid for a planned 48-week duration or until unacceptable tox...

journal_title：Pediatric blood & cancer

authors： Wright KD,Yao X,London WB,Kao PC,Gore L,Hunger S,Geyer R,Cohen KJ,Allen JC,Katzenstein HM,Smith A,Boklan J,Nazemi K,Trippett T,Karajannis M,Herzog C,Destefano J,Direnzo J,Pietrantonio J,Greenspan L,Cassidy D,Sch

更新日期：2021-02-01 00:00:00

abstract：:A male patient diagnosed with severe congenital protein C (PC) deficiency during the neonatal period was treated with long-term warfarin but frequently developed purpura fulminans and bleeding. At four years of age, edoxaban was initiated (direct oral anticoagulant [DOAC]). His d-dimer and fibrin/fibrinogen degradatio...

journal_title：Pediatric blood & cancer

authors： Watanabe K,Arakawa Y,Yanagi M,Isobe K,Mori M,Koh K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Posterior fossa syndrome (PFS) is defined as the temporary and complete loss of speech after posterior fossa surgery. The goal of this study was to identify incidence and risk factors for PFS and to determine accompanying neurobehavioral and psychologic problems. PROCEDURE:Between May 2007 and April 2009, c...

journal_title：Pediatric blood & cancer

authors： Küpeli S,Yalçın B,Bilginer B,Akalan N,Haksal P,Büyükpamukçu M

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:One of the most important adverse prognostic factors for adult renal cell carcinoma (RCC) is the retroperitoneal lymph node involvement. The aim of this article is to study the prognostic significance of local lymph node involvement in pediatric RCC and the role of retroperitoneal lymph node dissection (RLND...

journal_title：Pediatric blood & cancer

authors： Indolfi P,Bisogno G,Cecchetto G,Spreafico F,De Salvo GL,Collini P,Jenkner A,Inserra A,Schiavetti A,di Martino M,Casale F

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Central venous catheters (CVC) facilitate the management of patients with cancer. Optimal timing for placement of a CVC is controversial. We sought to determine whether early placement in children with acute lymphoblastic leukemia (ALL), a group at high risk for infection and thrombosis, was associated with ...

journal_title：Pediatric blood & cancer

authors： Gonzalez G,Davidoff AM,Howard SC,Pui CH,Rao BN,Shenep JL,Wozniak A,Shochat SJ

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The efficacy of combination chemotherapy with methotrexate (MTX) and asparaginase is not well known in relapsed and refractory acute leukemia after contemporary therapy. PROCEDURE:A retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML) who received MTX and aspara...

journal_title：Pediatric blood & cancer

authors： Buaboonnam J,Cao X,Pauley JL,Pui CH,Ribeiro RC,Rubnitz JE,Inaba H

更新日期：2013-07-01 00:00:00

abstract：:Minimal residual disease (MRD) is an independent predictor of relapse risk in children with leukemia and is widely used for risk-adapted treatment. This article summarizes current evidence supporting the use of MRD, including clinical significance, current international clinical practice, impact statement, and recomme...

journal_title：Pediatric blood & cancer

authors： Athale UH,Gibson PJ,Bradley NM,Malkin DM,Hitzler J,POGO MRD Working Group.

更新日期：2016-06-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a localized tumor composed of immature myeloid cells. This extramedullary tumor can present before, concurrent with or after the diagnosis of acute myeloid leukemia. GS is extremely uncommon in acute promyelocytic leukemia (APL). As a proportion of patients never develop systemic disease, ...

journal_title：Pediatric blood & cancer

authors： Worch J,Ritter J,Frühwald MC

更新日期：2008-03-01 00:00:00

abstract：:Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen i...

journal_title：Pediatric blood & cancer

authors： Naithani R,Kumar R,Mahapatra M

更新日期：2008-08-01 00:00:00

abstract：:Treatment recommendations for endemic Burkitt lymphoma (BL) in settings with only minimum requirements for curative treatment (PODC setting 1) are described. The reported cure rate for endemic BL is usually <50%. Facilities within setting 1 differ. Three treatment schedules are proposed based on: (1) when accurate sta...

journal_title：Pediatric blood & cancer

authors： Hesseling P,Israels T,Harif M,Chantada G,Molyneux E,Pediatric Oncology in Developing Countries.

更新日期：2013-03-01 00:00:00