Abstract：
:Sleep disordered breathing (SDB) is a common condition and could be a risk factor for cardiovascular morbidity and mortality. However, the pathogenesis of SDB remains to be elucidated. In general, SDB is divided into two forms, obstructive and central sleep apnea (OSA and CSA, respectively). OSA results from the sleep-related collapse of the upper airway (UA) in association with multiple factors like race, gender, obesity and UA dimensions. CSA primarily results from a fall in PaCO2 to a level below the apnea threshold during sleep through the reflex inhibition of central respiratory drive. It has been reported that UA alterations (i.e., collapse or dilation) can be observed in CSA. This review highlights the roles of the UA in the pathogenesis and pathophysiology of SDB.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Taranto Montemurro L,Kasai Tsubject
Has Abstractpub_date
2014-02-01 00:00:00pages
25-40issue
1eissn
0026-4806issn
1827-1669pii
R10Y2014N01A0025journal_volume
105pub_type
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