Abstract：
:Use and non-use of body parts during goal-directed action are major forces driving reorganisation of neural processing. We investigated changes in functional brain activity resulting from acute short-term immobilisation of the dominant right hand. Informed by the concept of object affordances, we predicted that the presence or absence of a limb restraint would influence the perception of graspable objects in a laterally specific way. Twenty-three participants underwent fMRI scanning during a passive object-viewing task before the intervention as well as with and without wearing an orthosis. The right dorsal premotor cortex and the left cerebellum were more strongly activated when the handle of an object was oriented towards the left hand while the right hand was immobilised compared with a situation where the hand was not immobilised. The cluster in the premotor cortex showing an interaction between condition (with restraint, without restraint) and stimulus action side (right vs. left) overlapped with the general task vs. baseline contrast prior to the intervention, confirming its functional significance for the task. These results show that acute immobilisation of the dominant right hand leads to rapid changes of the perceived affordance of objects. We conclude that changes in action requirements lead to almost instantaneous changes in functional activation patterns, which in turn may trigger structural cortical plasticity.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Kühn S,Werner A,Lindenberger U,Verrel Jdoi
10.1016/j.neuroimage.2014.02.003subject
Has Abstractpub_date
2014-05-15 00:00:00pages
69-73eissn
1053-8119issn
1095-9572pii
S1053-8119(14)00094-9journal_volume
92pub_type
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