Excitatory amino acid receptors and depolarization-induced Ca2+ influx into hippocampal slices.

abstract：:The spontaneously hypertensive rat (SHR) is widely used as a model of attention-deficit/hyperactivity disorder (ADHD). Deficits in central nicotinic receptors (nAChRs) have been previously observed in SHRs, which is interesting since epidemiological studies have identified an association between smoking and ADHD sympt...

journal_title：Journal of neurochemistry

authors： Wigestrand MB,Mineur YS,Heath CJ,Fonnum F,Picciotto MR,Walaas SI

更新日期：2011-10-01 00:00:00

abstract：:The changes of glutathione S-transferase activity were investigated using rat brain astroglioma C6 cells that were synchronized at different phases of the cell cycle. The enzyme showed two significant activity peaks at G2 and G1 phases. Furthermore, when C6 glioma cells were exposed to a culture medium supplemented wi...

journal_title：Journal of neurochemistry

authors： Senjo M,Ishibashi T

更新日期：1988-01-01 00:00:00

abstract：:The effect of cerebral hypoxia-ischemia (HI) on levels and tyrosine phosphorylation of the NMDA receptor was examined in 7- (P7) and 21 (P21)-day-old rats. Unilateral HI was administered by ligation of the right common carotid artery and exposure to an atmosphere of 8% O2/92% N2 for 2 (P7) or 1.5 (P21) h. This duratio...

journal_title：Journal of neurochemistry

authors： Gurd JW,Bissoon N,Beesley PW,Nakazawa T,Yamamoto T,Vannucci SJ

更新日期：2002-08-01 00:00:00

abstract：:Exogenous phospholipases have been used extensively as tools to study the role of membrane lipids in receptor mechanisms. We used in vitro quantitative autoradiography to evaluate the effect of phospholipase A2 (PLA2) on N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in rat brain. PLA2 pretreatment induc...

journal_title：Journal of neurochemistry

authors： Catania MV,Hollingsworth Z,Penney JB,Young AB

更新日期：1993-01-01 00:00:00

abstract：:To examine the correlation between the structure of Bcl-2 and its inhibitory function of c-Jun N-terminal kinase (JNK) and caspase activity, we established a dopaminergic neuronal cell line, MN9D overexpressing Bcl-2 (MN9D/Bcl-2) or its structural mutants. The mutants comprised a point mutation in the BH1 (G145A; MN9D...

journal_title：Journal of neurochemistry

authors： Choi WS,Yoon SY,Chang II,Choi EJ,Rhim H,Jin BK,Oh TH,Krajewski S,Reed JC,Oh YJ

更新日期：2000-04-01 00:00:00

abstract：:The nervous tissue-specific protein B-50 (GAP-43), which has been implicated in the regulation of neurotransmitter release, is a member of a family of atypical calmodulin-binding proteins. To investigate to what extent calmodulin and the interaction between B-50 and calmodulin are involved in the mechanism of Ca(2+)-i...

journal_title：Journal of neurochemistry

authors： Hens JJ,Oestreicher AB,De Wit M,Marquart A,Gispen WH,De Graan PN

更新日期：1996-05-01 00:00:00

abstract：:The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-bin...

journal_title：Journal of neurochemistry

authors： Breuskin I,Bodson M,Thelen N,Thiry M,Borgs L,Nguyen L,Stolt C,Wegner M,Lefebvre PP,Malgrange B

更新日期：2010-09-01 00:00:00

abstract：:Aromatic L-amino acid decarboxylase (AAAD) activity of the rat retina increases when animals are placed in a lighted environment from the dark. The rise of activity can be inhibited by administering alpha 2 adrenoceptor agonists. In the dark, the enzyme activity can be made to increase by administering alpha 2 adrenoc...

journal_title：Journal of neurochemistry

authors： Rossetti Z,Krajnc D,Neff NH,Hadjiconstantinou M

更新日期：1989-02-01 00:00:00

abstract：:Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction (PCR)-amplified alpha 6 cDNA prepared from rat cerebellar mRNA lacked nucleotides 226-255 as estimated by counting single-stranded ...

journal_title：Journal of neurochemistry

authors： Korpi ER,Kuner T,Kristo P,Köhler M,Herb A,Lüddens H,Seeburg PH

更新日期：1994-09-01 00:00:00

abstract：:cDNAs have been cloned that encode the chicken (Gallus domesticus) gamma-aminobutyric acidA receptor gamma 1 subunit, the mature sequence of which shares 90, 79, and 69% identity with those of the rat gamma 1, gamma 2, and gamma 3 subunits, respectively. In situ hybridization reveals that there are pronounced differen...

journal_title：Journal of neurochemistry

authors： Glencorse TA,Darlison MG,Barnard EA,Bateson AN

更新日期：1993-12-01 00:00:00

abstract：:The effects of the protein kinase inhibitor H-7 on early and delayed responses to nerve growth factor (NGF) were investigated in PC12 cells. H-7 reduced the NGF-induced expression of c-Fos in a dose-dependent manner without affecting the time course of c-Fos appearance. Conversely, H-7 potentiated delayed NGF effects,...

journal_title：Journal of neurochemistry

authors： Kahle P,Mangold M,Kuwahara T,Schubenel R,Hertel C

更新日期：1994-02-01 00:00:00

abstract：:We measured the activity of cathepsin D, the major cerebral protease, in 50 separate areas of the central nervous system of adult and aged humans, using hemoglobin as the substrate. The activity showed significant regional heterogeneity, with average differences of 50-100% between the lower and higher level areas, and...

journal_title：Journal of neurochemistry

authors： Banay-Schwartz M,DeGuzman T,Kenessey A,Palkovits M,Lajtha A

更新日期：1992-06-01 00:00:00

abstract：:We previously reported that nerve terminals and glial cells lack an active uptake system capable of terminating transmitter action of substance P (SP). In the present study, we demonstrated the existence of an active uptake system for SP carboxy-terminal heptapeptide, (5-11)SP. When the slices from either rat brain or...

journal_title：Journal of neurochemistry

authors： Nakata Y,Kusaka Y,Yajima H,Segawa T

更新日期：1981-12-01 00:00:00

abstract：:In adult New Zealand white rabbits, the effects of food deprivation and of massive elevations of plasma uridine or thymidine concentrations on CSF and plasma nucleoside and oxypurine concentrations were studied. Nucleoside and oxypurine levels were determined by high performance liquid chromatography using unequivocal...

journal_title：Journal of neurochemistry

authors： Eells JT,Spector R,Huntoon S

更新日期：1984-06-01 00:00:00

abstract：:We studied the effects of 12-O-tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC) activator, and calyculin A (CLA), an inhibitor of type 1 and 2A serine/threonine phosphatases, on serotonin uptake by a human placenta choriocarcinoma cell line (BeWo) and COS-7 cells expressing recombinant serotonin transpo...

journal_title：Journal of neurochemistry

authors： Sakai N,Sasaki K,Nakashita M,Honda S,Ikegaki N,Saito N

更新日期：1997-06-01 00:00:00

abstract：:Metallothionein (MT)-III, a member of the MT family of metal-binding proteins, is mainly expressed in the CNS and is abundant in glutamatergic neurons. Results in genetically altered mice indicate that MT-III may play neuroprotective roles in the brain, but the mechanisms through which this protein functions have not ...

journal_title：Journal of neurochemistry

authors： Montoliu C,Monfort P,Carrasco J,Palacios O,Capdevila M,Hidalgo J,Felipo V

更新日期：2000-07-01 00:00:00

abstract：:A specific and sensitive gas chromatographic-mass spectrometric assay for measurement of normetanephrine (NMN) in different rat brain regions is presented. The results show that hypothalamus contains the highest concentrations of the norepinephrine metabolite. An increase of NMN concentrations has been detected in ani...

journal_title：Journal of neurochemistry

authors： Mocchetti I,De Angelis L,Racagni G

更新日期：1981-12-01 00:00:00

abstract：:The changes in activity of phospholipid methyltransferase I and [3H]S-adenosyl-L-homocysteine ([3H]SAH) binding were determined in cortical membrane preparations from newborn rats and rats 1, 2, and 8 months old. The activity of phospholipid methyltransferase I and the [3H]SAH binding were significantly greater (respe...

journal_title：Journal of neurochemistry

authors： Gharib A,Rey C,Fonlupt P,Sarda N,Pacheco H

更新日期：1985-07-01 00:00:00

abstract：:We recently found that alternative transcripts of tissue transglutaminase (tTG or TG2) were present in hippocampal brain regions of Alzheimer's disease (AD), but not in control, non-demented, age-matched brains. Since antecedent non-severe trauma has been implicated in AD and other neurodegenerative diseases, such as ...

journal_title：Journal of neurochemistry

authors： Festoff BW,SantaCruz K,Arnold PM,Sebastian CT,Davies PJ,Citron BA

更新日期：2002-05-01 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative condition characterized by pathology in the brain and peripheral tissues. Hyperactivity of the innate immune system, due in part to NFκB pathway dysregulation, is an early and active component of HD. Evidence suggests targeting immune disruption may slow disease progres...

journal_title：Journal of neurochemistry

authors： Dobson L,Träger U,Farmer R,Hayardeny L,Loupe P,Hayden MR,Tabrizi SJ

更新日期：2016-06-01 00:00:00

abstract：:Abstract The dualistic activities of the amyloid beta (Abeta) peptide as a pro-oxidant and ubiquitous constituent of amyloid deposits in Alzheimer's disease plaques and as an antioxidant of purported physiological function has been suggested but the mechanisms are far from being understood. In this report we measure s...

journal_title：Journal of neurochemistry

authors： Kuperstein F,Brand A,Yavin E

更新日期：2004-11-01 00:00:00

abstract：:Sprague-Dawley rats were fed one of three purified diets--10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil--through two generations. At 60-80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidylethanolamine, plasmalogen phosphatidylethanolamine, and com...

journal_title：Journal of neurochemistry

authors： Brown ML,Marshall LA,Johnston PV

更新日期：1984-11-01 00:00:00

abstract：:A contribution of α-Synuclein (α-Syn) to etiology of Parkinson´s disease (PD) and Dementia with Lewy bodies (DLB) is currently undisputed, while the impact of the closely related β-Synuclein (β-Syn) on these disorders remains enigmatic. β-Syn has long been considered to be an attenuator of the neurotoxic effects of α-...

journal_title：Journal of neurochemistry

authors： Raina A,Leite K,Guerin S,Mahajani SU,Chakrabarti KS,Voll D,Becker S,Griesinger C,Bähr M,Kügler S

更新日期：2020-07-30 00:00:00

abstract：:When activated by proinflammatory stimuli, microglia release substantial levels of glutamate, and mounting evidence suggests this contributes to neuronal damage during neuroinflammation. Prior studies indicated a role for the Xc exchange system, an amino acid transporter that antiports glutamate for cystine. Because c...

journal_title：Journal of neurochemistry

authors： Barger SW,Goodwin ME,Porter MM,Beggs ML

更新日期：2007-06-01 00:00:00

abstract：:The relationships between presynaptic acetylcholinesterase (AChE) and high-affinity choline uptake (HACU) were investigated using a monolayer of rat cortex synaptosomes in superfusion conditions. The following sets of experiments were performed: determination of [3H]choline ([3H]Ch) uptake during superfusion with [3H]...

journal_title：Journal of neurochemistry

authors： Raiteri M,Marchi M,Caviglia AM

更新日期：1986-12-01 00:00:00

abstract：:Several Good buffers (MOPS, ACES, BES, HEPES, ADA, and PIPES) competitively inhibited both high-affinity and low-affinity [3H]gamma-aminobutyric acid receptor binding to rat brain synaptic membranes. The most potent inhibitor was MOPS, which had Ki values of 180 nM and 79 nM for the high- and low-affinity binding site...

journal_title：Journal of neurochemistry

authors： Tunnicliff G,Smith JA

更新日期：1981-03-01 00:00:00

abstract：:Acetylcholine is a key neurotransmitter of the inner ear efferent system. In this study, we identify two novel nAChR subunits in the inner ear: α1 and γ, encoded by Chrna1 and Chrng, respectively. In situ hybridization shows that the messages of these two subunits are present in vestibular and cochlear hair cells duri...

journal_title：Journal of neurochemistry

authors： Scheffer D,Sage C,Plazas PV,Huang M,Wedemeyer C,Zhang DS,Chen ZY,Elgoyhen AB,Corey DP,Pingault V

更新日期：2007-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) receptor (PAC1R) is a class B Gprotein-coupled receptor (GPCR) that is widely expressed in the human body and is involved in neuronal differentiation. As class B GPCRs are known to form heterocomplexes with family members, we hypothesized that PAC1R mediates neuro...

journal_title：Journal of neurochemistry

authors： Ke R,Lok SIS,Singh K,Chow BKC,Lee LTO

更新日期：2020-10-20 00:00:00

abstract：:Extracellular dopamine (DA) concentrations estimated by transcerebral dialysis and D1-dependent c-fos expression, as demonstrated by Fos immunohistochemistry, were studied after blockade of DA reuptake by GBR-12909. Rats implanted with dialysis probes in the dorsal caudate-putamen did not show any Fos-positive neurona...

journal_title：Journal of neurochemistry

authors： Morelli M,Carboni E,Cozzolino A,Tanda GL,Pinna A,Di Chiara G

更新日期：1992-09-01 00:00:00

abstract：:Repeated cocaine administration results in persistent changes in synaptic function in the mesolimbic dopamine system that are thought to be critical for the transition to addiction. Cytoskeletal rearrangement and actin dynamics are essential for this drug-dependent plasticity. Cocaine administration increases levels o...

journal_title：Journal of neurochemistry

authors： Lavaur J,Mineur YS,Picciotto MR

更新日期：2009-12-01 00:00:00