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Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.

Abstract：

:In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Benz S,Nötzli S,Siegel JS,Eberli D,Jessen HJ

doi

10.1021/jm4016137

subject

Has Abstract

pub_date

2013-12-27 00:00:00

pages

10171-82

issue

24

eissn

0022-2623

issn

1520-4804

journal_volume

56

pub_type

杂志文章

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