Evolutionary lag times and recent origin of the biota of an ancient desert (Atacama-Sechura).

abstract：:The amino acid sequence of blastokinin, also called uteroglobin, has been determined by a combined study of both the intact native molecule and the peptide fragments resulting from tryptic and chymotryptic digestions. Sequence analyses performed by automated methods and by sequential digestion with leucine aminopeptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popp RA,Foresman KR,Wise LD,Daniel JC Jr

更新日期：1978-11-01 00:00:00

abstract：:The pathogenesis of tuberculous meningitis, a devastating complication of tuberculosis in man, is poorly understood. We previously reported that rabbits with experimental tuberculous meningitis were protected from death by a combination of antibiotics and thalidomide therapy. Survival was associated with inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsenova L,Bergtold A,Freedman VH,Young RA,Kaplan G

更新日期：1999-05-11 00:00:00

abstract：:We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pennings S,Meersseman G,Bradbury EM

更新日期：1994-10-25 00:00:00

abstract：:Translation elongation factor P (EF-P) stimulates ribosomal peptidyltransferase activity. EF-P is conserved in bacteria and is essential for cell viability. Eukarya and Archaea have an EF-P homologue, eukaryotic initiation factor 5A (eIF-5A). In the present study, we determined the crystal structure of EF-P from Therm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanawa-Suetsugu K,Sekine S,Sakai H,Hori-Takemoto C,Terada T,Unzai S,Tame JR,Kuramitsu S,Shirouzu M,Yokoyama S

更新日期：2004-06-29 00:00:00

abstract：:Recent theory suggests that animals should switch facultatively among canonical movement modes as a complex function of internal state, landscape characteristics, motion capacity, and navigational capacity. We tested the generality of this paradigm for free-ranging elk (Cervus elaphus) over 5 orders of magnitude in ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fryxell JM,Hazell M,Börger L,Dalziel BD,Haydon DT,Morales JM,McIntosh T,Rosatte RC

更新日期：2008-12-09 00:00:00

abstract：:Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clathrin-mediated endocytosis depends on the protein autosomal recessive hypercholesterolemia (ARH), whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dvir H,Shah M,Girardi E,Guo L,Farquhar MG,Zajonc DM

更新日期：2012-05-01 00:00:00

abstract：:To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically characterized DLBCL cell lines. Dasatinib, a multikinase inhibitor, was ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scuoppo C,Wang J,Persaud M,Mittan SK,Basso K,Pasqualucci L,Rabadan R,Inghirami G,Grandori C,Bosch F,Dalla-Favera R

更新日期：2019-08-20 00:00:00

abstract：:The biosynthesis of fibronectin during the in vivo development of matrix-induced endochondral bone was investigated by using [35S]methionine in rats. The dmineralized bone matrix that was implanted subcutaneously to induce local bone formation bound circulating fibronectin. This may be an important initial requirement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss RE,Reddi AH

更新日期：1980-04-01 00:00:00

abstract：:The massive forests of central Amazonia are often considered relatively resilient against climatic variation, but this view is challenged by the wildfires invoked by recent droughts. The impact of such fires that spread from pervasive sources of ignition may reveal where forests are less likely to persist in a drier f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores BM,Holmgren M,Xu C,van Nes EH,Jakovac CC,Mesquita RCG,Scheffer M

更新日期：2017-04-25 00:00:00

abstract：:Recent technical advances allow detection of several hundred volatile organic compounds (VOCs) in human exhaled air, many of which reflect unidentified endogenous pathways. Our group has previously estimated plasma glucose levels in healthy adults during a standard oral glucose tolerance test via exhaled VOC analysis....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novak BJ,Blake DR,Meinardi S,Rowland FS,Pontello A,Cooper DM,Galassetti PR

更新日期：2007-10-02 00:00:00

abstract：:ATP-binding cassette (ABC) transporters use ATP to drive solute transport across biological membranes. Members of this superfamily have crucial roles in cell physiology, and some of the transporters are linked to severe diseases. However, understanding of the transport mechanism, especially of human ABC exporters, is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zollmann T,Moiset G,Tumulka F,Tampé R,Poolman B,Abele R

更新日期：2015-02-17 00:00:00

abstract：:Methods are described for the removal of the sporophytic pollen grain coating of Brassica oleracea and for the isolation of coat polypeptides. The coat contains a small number of proteins ranging from 6 to 45 kDa. Many of the larger proteins are glycosylated, while all carry high positive charges resulting in pI value...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doughty J,Hedderson F,McCubbin A,Dickinson H

更新日期：1993-01-15 00:00:00

abstract：:To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Yu W,Wang B,Zhao Y,En K,Zhu J,Cheng X,Zhou C,Lin H,Wang Z,Hojaiji H,Yeung C,Milla C,Davis RW,Emaminejad S

更新日期：2020-08-11 00:00:00

abstract：:It has long been known that cholera outbreaks can be initiated when Vibrio cholerae, the bacterium that causes cholera, is present in drinking water in sufficient numbers to constitute an infective dose, if ingested by humans. Outbreaks associated with drinking or bathing in unpurified river or brackish water may dire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobitz B,Beck L,Huq A,Wood B,Fuchs G,Faruque AS,Colwell R

更新日期：2000-02-15 00:00:00

abstract：:Climate change over the next century is predicted to cause widespread maladaptation in natural systems. This prediction, as well as many sustainable management and conservation practices, assumes that species are adapted to their current climate. However, this assumption is rarely tested. Using a large-scale common ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Browne L,Wright JW,Fitz-Gibbon S,Gugger PF,Sork VL

更新日期：2019-12-10 00:00:00

abstract：:The kinetics of hepatic uptake and degradation of sphingomyelin/cholesterol (2:1, M/M) small unilamellar liposomes were investigated in a BALB/c mouse. The tissue distribution of liposomes was determined by scintillation spectrometry. The percentage of intact liposomes in tissues was estimated by the technique of gamm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang KJ,Luk KF,Beaumier PL

更新日期：1980-07-01 00:00:00

abstract：:The levels of c-myc, c-fos, and JE mRNAs accumulate in a biphasic pattern following infection of quiescent BALB/c 3T3 mouse cells with polyomavirus. Maximal levels of c-myc and c-fos mRNAs were seen within 1 hr and were nearly undetectable at 6 hr after infection. At 12 hr after infection mRNA levels were again maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zullo J,Stiles CD,Garcea RL

更新日期：1987-03-01 00:00:00

abstract：:We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swann AL,Fung IY,Chiang JC

更新日期：2012-01-17 00:00:00

abstract：:Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rall LB,Pictet RL,Williams RH,Rutter WJ

更新日期：1973-12-01 00:00:00

abstract：:Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purse BW,Rebek J Jr

更新日期：2005-08-02 00:00:00

abstract：:We report potent inhibition of the Mg(II).ATP-dependent protein phosphatase, Fc.M, by the regulatory subunit dimer of type II cAMP-dependent protein kinase, RII2. The protein kinase catalytic subunit has no effect on phosphatase activity and is unable to substitute for kinase FA in the kinase FA- and Mg(II).ATP-mediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jurgensen SR,Chock PB,Taylor S,Vandenheede JR,Merlevede W

更新日期：1985-11-01 00:00:00

abstract：:Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly, and birth defects. The cause of unwan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bittigau P,Sifringer M,Genz K,Reith E,Pospischil D,Govindarajalu S,Dzietko M,Pesditschek S,Mai I,Dikranian K,Olney JW,Ikonomidou C

更新日期：2002-11-12 00:00:00

abstract：:The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion of activated T and B lymphocytes by CD4+ T cells expressing the Fas ligand. Because macrophages play a key role in peripheral immunity, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashany D,Song X,Lacy E,Nikolic-Zugic J,Friedman SM,Elkon KB

更新日期：1995-11-21 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer. Mitochondria are an important source of ROS; however, the spatiotemporal ROS events underlying oxidative cellular damage from dysfunctional mitochondria remain unresolved. To this end, we have developed and validated a chemoptogenet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian W,Kumar N,Roginskaya V,Fouquerel E,Opresko PL,Shiva S,Watkins SC,Kolodieznyi D,Bruchez MP,Van Houten B

更新日期：2019-09-10 00:00:00

abstract：:The hydrodynamic properties of the detergent-solubilized, terminal membrane complex of serum complement components C5-C9 [C5b-9(m)] were studied to obtain an estimate of its molecular weight. In a solution of Triton X-100/deoxycholate, the protein complex binds 17% Triton X-100 and 11% deoxycholate by weight. The sedi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhakdi S,Tranum-Jensen J

更新日期：1981-03-01 00:00:00

abstract：:Tooth decay (dental caries) is a widespread human disease caused by microbial biofilms. Streptococcus mutans, a biofilm-former, has been consistently associated with severe childhood caries; however, how this bacterium is spatially organized with other microorganisms in the oral cavity to promote disease remains unkno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim D,Barraza JP,Arthur RA,Hara A,Lewis K,Liu Y,Scisci EL,Hajishengallis E,Whiteley M,Koo H

更新日期：2020-06-02 00:00:00

abstract：:Rat thoracic aortic smooth muscle cells (line A10, ATCC CRL 1476) display a high density of atrial natriuretic factor (ANF) receptors. ANF stimulated the accumulation of cGMP in these cells in a time- and dose-dependent fashion. These cells are known to display a high density of vasopressin receptors of the vascular V...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nambi P,Whitman M,Gessner G,Aiyar N,Crooke ST

更新日期：1986-11-01 00:00:00

abstract：:Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels, cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate receptors in cerebellar slices. Nitric oxide synthase (EC 1.14.23.-) immunoreactivity is colocalized with nicotinamide adenine di-nucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dawson VL,Dawson TM,London ED,Bredt DS,Snyder SH

更新日期：1991-07-15 00:00:00

abstract：:The rat brain increases >6x in mass from birth to adulthood, presumably through the addition of glial cells and increasing neuronal size, without the addition of neurons. To test this hypothesis, here we investigate quantitatively the postnatal changes in the total number of neuronal and non-neuronal cells in the deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bandeira F,Lent R,Herculano-Houzel S

更新日期：2009-08-18 00:00:00

abstract：:The replisome, the multiprotein system responsible for genome duplication, is a highly dynamic complex displaying a large number of different enzyme activities. Recently, the Saccharomyces cerevisiae minimal replication reaction has been successfully reconstituted in vitro. This provided an opportunity to uncover the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis JS,Spenkelink LM,Schauer GD,Hill FR,Georgescu RE,O'Donnell ME,van Oijen AM

更新日期：2017-10-03 00:00:00