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The power of exercise-induced T-wave alternans to predict ventricular arrhythmias in patients with implanted cardiac defibrillator.

Abstract：

:The power of exercise-induced T-wave alternans (TWA) to predict the occurrence of ventricular arrhythmias was evaluated in 67 patients with an implanted cardiac defibrillator (ICD). During the 4-year follow-up, electrocardiographic (ECG) tracings were recorded in a bicycle ergometer test with increasing workload ranging from zero (NoWL) to the patient's maximal capacity (MaxWL). After the follow-up, patients were classified as either ICD_Cases (n = 29), if developed ventricular tachycardia/fibrillation, or ICD_Controls (n = 38). TWA was quantified using our heart-rate adaptive match filter. Compared to NoWL, MaxWL was characterized by faster heart rates and higher TWA in both ICD_Cases (12-18 μ V vs. 20-39 μ V; P < 0.05) and ICD_Controls (9-15 μ V vs. 20-32 μ V; P < 0.05). Still, TWA was able to discriminate the two ICD groups during NoWL (sensitivity = 59-83%, specificity = 53-84%) but not MaxWL (sensitivity = 55-69%, specificity = 39-74%). Thus, this retrospective observational case-control study suggests that TWA's predictive power for the occurrence of ventricular arrhythmias could increase at low heart rates.

journal_name

J Healthc Eng

journal_title

Journal of healthcare engineering

authors

Burattini L,Man S,Sweene CA

doi

10.1260/2040-2295.4.2.167

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

167-84

issue

2

eissn

2040-2295

issn

2040-2309

pii

WX217663G4018V66

journal_volume

4

pub_type

杂志文章

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