Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography.

Abstract:

:Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication. Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection. The scaffolds examined by stereomicroscope, SEM, and μCT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity. The physical and mechanical properties of the scaffolds were investigated. It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds. A good scaffold design could create proper orientation of pores in a way to strengthen the scaffold structure. The drug delivery profile of the porous scaffolds was also analyzed using microbiological assay. The release rates of gentamicin from the scaffolds showed prolonged drug release at the levels higher than the minimum inhibitory concentrations for S. aureus and E. coli over a 2-week period. It indicated a potential of the scaffolds to serve as local antibiotic delivery to prevent bacterial infection.

journal_name

J Healthc Eng

authors

Channasanon S,Udomkusonsri P,Chantaweroad S,Tesavibul P,Tanodekaew S

doi

10.1155/2017/9547896

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

9547896

eissn

2040-2295

issn

2040-2309

journal_volume

2017

pub_type

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