当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound.

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound.

Abstract：

:Noninvasive, targeted drug delivery to the brain can be achieved using transcranial focused ultrasound (FUS), which transiently increases the permeability of the blood-brain barrier (BBB) for localized delivery of therapeutics from the blood to the brain. Previously, we have demonstrated that FUS can deliver intravenously-administered antibodies to the brain of a mouse model of Alzheimer's disease (AD) and rapidly reduce plaques composed of amyloid-β peptides (Aβ). Here, we investigated two potential effects of transcranial FUS itself that could contribute to a reduction of plaque pathology, namely the delivery of endogenous antibodies to the brain and the activation of glial cells. We demonstrate that transcranial FUS application leads to a significant reduction in plaque burden four days after a single treatment in the TgCRND8 mouse model of AD and that endogenous antibodies are found bound to Aβ plaques. Immunohistochemical and western blot analyses showed an increase in endogenous immunoglobulins within the FUS-targeted cortex. Subsequently, microglia and astrocytes in FUS-treated cortical regions show signs of activation through increases in protein expression and changes in glial size, without changes in glial cell numbers. Enhanced activation of glia correlated with increased internalization of Aβ in microglia and astrocytes. Together these data demonstrate that FUS improved the bioavailability of endogenous antibodies and led to a temporal activation of glial cells, providing evidence towards antibody- and glia-dependent mechanisms of FUS-mediated plaque reduction.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Jordão JF,Thévenot E,Markham-Coultes K,Scarcelli T,Weng YQ,Xhima K,O'Reilly M,Huang Y,McLaurin J,Hynynen K,Aubert I

doi

10.1016/j.expneurol.2013.05.008

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

16-29

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(13)00154-4

journal_volume

248

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized by motor neuron death. Since most ALS patients succumb to ventilatory failure from loss of respiratory motor neurons, any effective ALS treatment must preserve and/or restore breathing capacity. In rats over-expressi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.08.011

    authors： Nichols NL,Satriotomo I,Harrigan DJ,Mitchell GS

    更新日期：2015-11-01 00:00:00

  • Fear state induced by ethanol withdrawal may be due to the sensitization of the neural substrates of aversion in the dPAG.

    abstract：:The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.02.004

    authors： Cabral A,Isoardi N,Salum C,Macedo CE,Nobre MJ,Molina VA,Brandão ML

    更新日期：2006-07-01 00:00:00

  • Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury.

    abstract：:Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.07.013

    authors： Meves JM,Geoffroy CG,Kim ND,Kim JJ,Zheng B

    更新日期：2018-11-01 00:00:00

  • Attention-related unit activity in the frontal association cortex during a go/no-go visual discrimination task.

    abstract：:Unit activity related to a go/no-go visual discrimination task was studied in four rhesus monkeys. We recorded 272 task-related cells from frontal cortex in a region extending from the midprincipal sulcus to the central sulcus, and medially to the cingulate sulcus. Units located in anterior regions (dorsolateral prefr...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90213-5

    authors： Pragay EB,Mirsky AF,Nakamura RK

    更新日期：1987-06-01 00:00:00

  • The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin.

    abstract：:The vanilloid receptor TRPV(1) is a key nociceptive molecule located in primary afferent nociceptive neurons in dorsal root ganglia (DRG) for initiating neurogenic inflammation and pain. Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activati...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.12.011

    authors： Xu X,Wang P,Zou X,Li D,Fang L,Gong K,Lin Q

    更新日期：2010-03-01 00:00:00

  • Development of immune hyperinnervation in NGF-transgenic mice.

    abstract：:Sympathetic innervation of lymphoid tissues is localized to specific tissue compartments, but little is known of the "factors" that are important in establishing this pattern during development. Numerous studies have shown interactions of nerve growth factor (NGF) with the immune system, which may include modulation o...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6711

    authors： Carlson SL,Johnson S,Parrish ME,Cass WA

    更新日期：1998-01-01 00:00:00

  • Increased epileptogenicity in a mouse model of neurofibromatosis type 1.

    abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113373

    authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

    更新日期：2020-09-01 00:00:00

  • Docosahexaenoic acid inhibits mechanical allodynia and thermal hyperalgesia in diabetic rats by decreasing the excitability of DRG neurons.

    abstract：:Diabetes mellitus is a common metabolic disease in human beings with characteristic symptoms of hyperglycemia, chronic inflammation and insulin resistance. One of the most common complications of early-onset diabetes mellitus is peripheral diabetic neuropathy, which is manifested either by loss of nociception or by al...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.06.022

    authors： Heng LJ,Qi R,Yang RH,Xu GZ

    更新日期：2015-09-01 00:00:00

  • Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats.

    abstract：:Posttraumatic inflammation has been implicated in secondary tissue damage after spinal cord injury (SCI). Tumor necrosis factor-alpha (TNF-alpha) is a key inflammatory mediator that is increasingly expressed after SCI. The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whet...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00135-3

    authors： Yan P,Liu N,Kim GM,Xu J,Xu J,Li Q,Hsu CY,Xu XM

    更新日期：2003-10-01 00:00:00

  • Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.

    abstract：:The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.02.036

    authors： Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

    更新日期：2015-05-01 00:00:00

  • Specific inhibition of myelination by lead in vitro; comparison with arsenic, thallium, and mercury.

    abstract：:Lead induces peripheral nerve segmental demyelination in rats. Arsenic and thallium produce a peripheral neuropathy characterized by axonal degeneration in humans. Mercury and thallium appear to damage both the peripheral and the central nervous system. It is not known whether this difference in effect is due to diffe...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90283-9

    authors： Windebank AJ

    更新日期：1986-10-01 00:00:00

  • Unilateral ibotenic acid lesion of the caudate putamen results in D2 receptor alterations on the contralateral side.

    abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1993.1069

    authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

    更新日期：1993-05-01 00:00:00

  • Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer's disease.

    abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.08.017

    authors： Ribes D,Colomina MT,Vicens P,Domingo JL

    更新日期：2008-12-01 00:00:00

  • Priming by muscle inflammation alters the response and vulnerability to axotomy-induced damage of the rat facial motor nucleus.

    abstract：:To ascertain whether signaling due to peripheral inflammation affects motoneuron vulnerability, we examined in adult rats the reaction to axonal injury of facial motoneurons primed by muscle inflammation. In this double-hit paradigm, preconditioning was achieved by injections into the facial muscles of the T cell mito...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2002.7908

    authors： Mariotti R,Tongiorgi E,Bressan C,Kristensson K,Bentivoglio M

    更新日期：2002-07-01 00:00:00

  • Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletion.

    abstract：:A neurochemical target at which cannabinoids interact to have global effects on behavior is brain noradrenergic circuitry. Acute and repeated administration of a cannabinoid receptor synthetic agonist is capable of increasing multiple indices of noradrenergic activity. This includes cannabinoid-induced 1) increases in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.03.010

    authors： Reyes BAS,Carvalho AF,Szot P,Kalamarides DJ,Wang Q,Kirby LG,Van Bockstaele EJ

    更新日期：2017-06-01 00:00:00

  • Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.

    abstract：:The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection. We used an in vitro model of chemotherapy i...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.08.013

    authors： Melli G,Taiana M,Camozzi F,Triolo D,Podini P,Quattrini A,Taroni F,Lauria G

    更新日期：2008-12-01 00:00:00

  • Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.

    abstract：:The sciatic nerve of adult mice was transected and proximal and distal nerve stumps were sutured into a nontoxic bioresorbable nerve guide. Nerve guide lumens were either empty or filled with a gel containing 80% laminin and additional extracellular matrix components. Two weeks later cells in the L3 through L5 dorsal ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90087-1

    authors： Madison R,da Silva CF,Dikkes P,Chiu TH,Sidman RL

    更新日期：1985-06-01 00:00:00

  • OP-1 enhances dendritic growth from cerebral cortical neurons in vitro.

    abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7194

    authors： Le Roux P,Behar S,Higgins D,Charette M

    更新日期：1999-11-01 00:00:00

  • Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease.

    abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2003.12.012

    authors： Betarbet R,Poisik O,Sherer TB,Greenamyre JT

    更新日期：2004-05-01 00:00:00

  • Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease in which the majority of upper and lower motor neurons are degenerated. Despite intensive efforts to identify drug targets and develop neuroprotective strategies, effective therapeutics for ALS remains unavailable. The identificatio...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.03.004

    authors： Ng SK,Higashimori H,Tolman M,Yang Y

    更新日期：2015-05-01 00:00:00

  • Light and confocal microscopic studies of evolutionary changes in neurofilament proteins following cortical impact injury in the rat.

    abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7244

    authors： Posmantur RM,Newcomb JK,Kampfl A,Hayes RL

    更新日期：2000-01-01 00:00:00

  • Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry.

    abstract：:Recent studies have implicated nitric oxide (NO) in several mechanisms related to neuronal degeneration and synaptic plasticity. In the present study, two models of traumatic neuronal injury were used to examine the expression of NOS following neuronal injury and its relationship to axonal sprouting and neuronal degen...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1993.1050

    authors： Wu W

    更新日期：1993-04-01 00:00:00

  • Differential impact of heavy cannabis use on sensory gating in schizophrenic patients and otherwise healthy controls.

    abstract：:Cannabis abuse may precipitate the onset of schizophrenia and a dysfunction of the endocannabinoid system may be involved in the pathology of schizophrenia. Nevertheless, only few studies have addressed the neurobiological consequences of cannabis abuse for the development and course of schizophrenia. We measured the ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.02.004

    authors： Rentzsch J,Penzhorn A,Kernbichler K,Plöckl D,Gómez-Carrillo de Castro A,Gallinat J,Jockers-Scherübl MC

    更新日期：2007-05-01 00:00:00

  • Increased number of new neurons in the olfactory bulb and hippocampus of adult non-human primates after focal ischemia.

    abstract：:Adult neurogenesis is modulated by growth factors, physical conditions, and other alterations in the physical microenvironment. We studied the effects of focal ischemia on neurogenesis in the subventricular zone (SVZ), olfactory bulb (OB), and hippocampal dentate gyrus (DG) (known to be persistent neurogenic regions) ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.03.012

    authors： Koketsu D,Furuichi Y,Maeda M,Matsuoka N,Miyamoto Y,Hisatsune T

    更新日期：2006-05-01 00:00:00

  • Transthyretin is not expressed by dorsal root ganglia cells.

    abstract：:Several mutations in transthyretin (TTR) are related to familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder caused by extracellular deposition of TTR fibrils, particularly in the peripheral nervous system (PNS). TTR is mainly synthesized by the liver and choroid plexus of the brain that contribute ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.08.019

    authors： Sousa MM,Saraiva MJ

    更新日期：2008-12-01 00:00:00

  • Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration.

    abstract：:Local application of exogenous agents with neurotrophic properties enhances the regenerative capacity of injured neurons, especially following reconstructions of long nerve gaps and delayed nerve repairs. Recent advances in biomaterials and biomedical engineering have provided options for the sustained and controlled ...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2018.08.014

    authors： Tajdaran K,Chan K,Gordon T,Borschel GH

    更新日期：2019-09-01 00:00:00

  • Autoradiographic measurement of relative changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons.

    abstract：:An autoradiographic method is described for detecting changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons of rats using [3H]difluoromethylornithine. An increase in binding to neurons was seen at 12 h and 1 day after crushing the postganglionic nerves. Binding returned to control values ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90097-x

    authors： Wells MR

    更新日期：1986-05-01 00:00:00

  • Lateralized wall-facing versus turning as measures of behavioral asymmetries and recovery of function after injection of 6-hydroxydopamine into the substantia nigra.

    abstract：:The tendency of a rat to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the dopamine agonist apomorphine reversed the direction ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90172-0

    authors： Steiner H,Bonatz AE,Huston JP,Schwarting R

    更新日期：1988-03-01 00:00:00

  • Ciliary neurotrophic factor is expressed in the magnocellular neurosecretory system of the rat in vivo: evidence for injury- and activity-induced upregulation.

    abstract：:Although ciliary neurotrophic factor (CNTF) has been shown to promote the survival of magnocellular neurons when applied exogenously to explants of the paraventricular and supraoptic nuclei (SON) in vitro, little is known regarding its expression or regulation in the adult magnocellular neurosecretory system (MNS) fol...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.09.009

    authors： Watt JA,Bone S,Pressler M,Cranston HJ,Paden CM

    更新日期：2006-01-01 00:00:00

  • Effect of norepinephrine depletion on audiogenic-like seizures elicited by microinfusion of an excitant amino acid into the inferior colliculus of normal rats.

    abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90070-s

    authors： Browning RA,Wang C,Faingold CL

    更新日期：1991-05-01 00:00:00