Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.

Abstract:

OBJECTIVE:The purpose of this study was to investigate clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials. METHOD:Thirty-six medication-naïve children ages 9-14 years diagnosed with attention-deficit/hyperactivity disorder (ADHD) were enrolled for 6 weeks in a crossover trial, with 2 weeks of methylphenidate, dextroamphetamine, and placebo, in a randomly assigned, counterbalanced sequence. Outcome measures constituted a computer-based continuous performance test combined with a motion tracking system (Qb Test) and an ADHD questionnaire rated by parents and teachers. RESULTS:Group analyses found significant treatment effects of similar size for the two stimulants on both outcome measures. Single-subject analyses revealed that each stimulant produced a favourable response in 26 children; however, an individual child frequently responded qualitatively or quantitatively differently to the two stimulants. By including both stimulants in the trial, the number of favorable responders increased from 26 (72%) to 33 (92%). In children with favorable responses of unequal strength to the two stimulants, a shift from inferior drug to best drug was associated with a 64% mean increase in the overall response strength score, as measured by the ADHD questionnaire. CONCLUSIONS:The likelihood of a favorable response and optimal response strength is increased by including both stimulants in the stimulant trial. The study was first registered in clinical trials 28 September 2010. Clinical Trials.gov Identifier: NCT01220440.

authors

Ramtvedt BE,Røinås E,Aabech HS,Sundet KS

doi

10.1089/cap.2012.0085

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

597-604

issue

9

eissn

1044-5463

issn

1557-8992

journal_volume

23

pub_type

杂志文章,随机对照试验
  • An open trial of paroxetine in the treatment of children and adolescents diagnosed with dysthymia.

    abstract::This open-label study examined the potential efficacy of paroxetine in the treatment of children and adolescents diagnosed with dysthymia over a period of 3 months. Seven subjects were evaluated by the Hamilton Depression Rating Scale (HAM-D), by the Clinical Global Impression Severity of Illness Scale (CGI-S), and th...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2000.10.103

    authors: Nobile M,Bellotti B,Marino C,Molteni M,Battaglia M

    更新日期:2000-07-01 00:00:00

  • Reboxetine as an optional treatment for hyperkinetic conduct disorder: a prospective open-label trial.

    abstract:BACKGROUND AND PURPOSE:Hyperkinetic conduct disorder (HCD) has been identified as a common psychiatric diagnosis among children and adolescents. This disorder affects many life aspects of both child and family. The aim of this study was to examine the efficacy of the selective norepinephrine reuptake inhibitor (SNRI), ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2005.15.259

    authors: Mozes T,Meiri G,Ben-Amity G,Sabbagh M,Weizman A

    更新日期:2005-04-01 00:00:00

  • Side effects from use of one or more psychiatric medications in a population-based sample of children and adolescents.

    abstract:OBJECTIVE:The purpose of this study was to investigate the side effect risks from using one or more psychiatric medications (including antipsychotics, antidepressants, α-2 agonists, benzodiazepines, mood stabilizers, and stimulants) among a national cohort of children and adolescents. METHODS:A questionnaire survey wa...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2013.0036

    authors: Hilt RJ,Chaudhari M,Bell JF,Wolf C,Koprowicz K,King BH

    更新日期:2014-03-01 00:00:00

  • Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases.

    abstract:OBJECTIVE:The aim of this study was to retrospectively review a large sample of children and adolescents with pervasive developmental disorders (PDDs) treated with open-label guanfacine in order to gather preliminary data as to its effectiveness and safety. METHOD:Eighty (80) subjects with PDDs (10 females, 70 males) ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/1044546041649084

    authors: Posey DJ,Puntney JI,Sasher TM,Kem DL,McDougle CJ

    更新日期:2004-07-01 00:00:00

  • Efficacy and safety of quetiapine in adolescents with schizophrenia investigated in a 6-week, double-blind, placebo-controlled trial.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of acute quetiapine monotherapy in adolescents with schizophrenia. METHODS:Patients ages 13-17 years with an American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR) diagnosis ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2011.0092

    authors: Findling RL,McKenna K,Earley WR,Stankowski J,Pathak S

    更新日期:2012-10-01 00:00:00

  • Omega-3 Fatty Acid Plasma Levels Before and After Supplementation: Correlations with Mood and Clinical Outcomes in the Omega-3 and Therapy Studies.

    abstract:OBJECTIVE:To examine fatty acid profiles, their response to omega-3 fatty acid (Ω3) supplementation, and associations with clinical status and treatment response in youth with mood disorders. METHODS:In a placebo-controlled 2X2 design, 7-14 year-olds (N = 95) in parallel pilot trials (depression N = 72; bipolar N = 23...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2016.0123

    authors: Arnold LE,Young AS,Belury MA,Cole RM,Gracious B,Seidenfeld AM,Wolfson H,Fristad MA

    更新日期:2017-04-01 00:00:00

  • Comorbid anxiety and social avoidance in treatment of severe childhood aggression: response to adding risperidone to stimulant and parent training; mediation of disruptive symptom response.

    abstract:OBJECTIVE:In the four-site Treatment of Severe Childhood Aggression (TOSCA) study, addition of risperidone to stimulant and parent training moderately improved parent-rated disruptive behavior disorder (DBD) symptoms. This secondary study explores outcomes other than DBD and attention-deficit/hyperactivity disorder (AD...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2014.0104

    authors: Arnold LE,Gadow KD,Farmer CA,Findling RL,Bukstein O,Molina BS,Brown NV,Li X,Rundberg-Rivera EV,Bangalore S,Buchan-Page K,Hurt EA,Rice R,McNamara NK,Aman MG

    更新日期:2015-04-01 00:00:00

  • A review of developmental aspects of cytochrome P450.

    abstract::This article surveys the development of human hepatic P450 cytochromes (CYPs) involved in xenobiotic metabolism from the fetus through the life span and explores possible clinical consequences of developmental issues. These hepatic P450 CYPs come "on line" at different times during fetal and infant development, and ea...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.1998.8.161

    authors: Oesterheld JR

    更新日期:1998-01-01 00:00:00

  • Academic, behavioral, and cognitive effects of OROS® methylphenidate on older children with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:To assess the effect of Osmotic-Release Oral System (OROS) methylphenidate (MPH) on a variety of measures evaluating academic performance, cognition, and social behavior in children with attention-deficit/hyperactivity disorder (ADHD). METHODS:This double-blind, randomized, placebo-controlled, crossover labo...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/cap.2010.0047

    authors: Wigal SB,Wigal T,Schuck S,Brams M,Williamson D,Armstrong RB,Starr HL

    更新日期:2011-04-01 00:00:00

  • Evaluation of patients' and parents' quality of life in a randomized placebo-controlled atomoxetine study in attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to demonstrate the superior efficacy of atomoxetine with respect to placebo and to compare parent and child perceptions of health-related quality of life (HRQoL). METHOD:This randomized, placebo-controlled, 12-week parallel clinical trial included 151 untreated children/adolescents ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2008.0109

    authors: Escobar R,Montoya A,Polavieja P,Cardo E,Artigas J,Hervas A,Fuentes J

    更新日期:2009-06-01 00:00:00

  • No Differences in Weight Gain Between Risperidone and Aripiprazole in Children and Adolescents After 12 Months.

    abstract:BACKGROUND:Weight gain due to the use of second-generation antipsychotics is a major health care issue for adult and paediatric psychiatric patients. Little is known about long-term weight gain effects of aripiprazole compared to risperidone in children and adolescents. OBJECTIVE:The primary aim of this study is to as...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0111

    authors: Schoemakers RJ,van Kesteren C,van Rosmalen J,Eussen MLJM,Dieleman HG,Beex-Oosterhuis MM

    更新日期:2019-04-01 00:00:00

  • Participant-perceived quality of life in a long-term, open-label trial of lisdexamfetamine dimesylate in adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVES:The purpose of this study was to assess long-term improvement in quality of life (QOL) in adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with lisdexamfetamine dimesylate (LDX). METHODS:Adolescents with ADHD treated for ≥3 weeks in a 4 week, placebo-controlled study entered a 1 year...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2013.0077

    authors: Childress AC,Cutler AJ,Saylor K,Gasior M,Hamdani M,Ferreira-Cornwell MC,Findling RL

    更新日期:2014-05-01 00:00:00

  • Employing parent, teacher, and youth self-report checklists in identifying pediatric bipolar spectrum disorders: an examination of diagnostic accuracy and clinical utility.

    abstract::The diagnosis of bipolar spectrum disorders (BPSD) is difficult to evaluate in child and adolescent populations. The current study examines whether commonly used behavior checklists- the Child Behavior Checklist, Teacher Report Form, and the Youth Self-Report form-are clinically useful in making a differential diagnos...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/104454603322724869

    authors: Kahana SY,Youngstrom EA,Findling RL,Calabrese JR

    更新日期:2003-01-01 00:00:00

  • Does comorbid depression predict subsequent adverse life events in youth with attention-deficit/hyperactivity disorders?

    abstract:OBJECTIVES:Studies have primarily focused on adverse life events (ALEs) as potential causes rather than as outcomes of pediatric depression. The current study prospectively examines ALEs in a sample of youth with attention-deficit/hyperactivity disorders (ADHD) to determine whether having a major depressive disorder (M...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2011.0046

    authors: Daviss WB,Diler R

    更新日期:2012-02-01 00:00:00

  • Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

    abstract:OBJECTIVE:The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). METHODS:One hundred and forty preschoolers with ADHD, who had improved with a...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2007.0058

    authors: Vitiello B,Abikoff HB,Chuang SZ,Kollins SH,McCracken JT,Riddle MA,Swanson JM,Wigal T,McGough JJ,Ghuman JK,Wigal SB,Skrobala AM,Davies M,Posner K,Cunningham C,Greenhill LL

    更新日期:2007-10-01 00:00:00

  • Sex differences in attentional performance and their modulation by methylphenidate in children with attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:Still little is known about neuropsychological differences between boys and girls with attention-deficit/hyperactivity disorder (ADHD) and whether there are sex-specific differences in the modulation of attentional performance by methylphenidate (MPH). METHOD:In this study, 27 males and 27 females between 8...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2009.0060

    authors: Günther T,Herpertz-Dahlmann B,Konrad K

    更新日期:2010-06-01 00:00:00

  • Palpebral twitching in a depressed adolescent on citalopram.

    abstract::Current estimates suggest that between 0.4% and 8.3% of children and adolescents are affected by major depression. We report a favorable response to treatment with citalopram by a 15-year-old boy with major depression who exhibited palpebral twitching during his first 2 weeks of treatment. This may have been a side ef...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/10445460152595621

    authors: Rojas VM,Silva R

    更新日期:2001-10-01 00:00:00

  • Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implications.

    abstract:BACKGROUND:Recent evidence indicates that atypical antipsychotics represent a promising option for the treatment of autistic disorder. In particular, risperidone appears to be effective in treating aggressiveness, hyperactivity, irritability, stereotypies, social withdrawal, and lack of interests. OBJECTIVE:The aim of...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/104454604773840472

    authors: Gagliano A,Germanò E,Pustorino G,Impallomeni C,D'Arrigo C,Calamoneri F,Spina E

    更新日期:2004-04-01 00:00:00

  • A brief motivational intervention for preventing medication-associated weight gain among youth with bipolar disorder: treatment development and case report.

    abstract::Bipolar disorder (BP) in youth is an impairing psychiatric disorder associated with high rates of relapse and recurrence. High rates of psychiatric and medical co-morbidities account for additional illness burden in pediatric BP. The elevated risk of overweight and obesity in this population is of particular concern. ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0104

    authors: Goldstein TR,Goldstein BI,Mantz MB,Bailey B,Douaihy A

    更新日期:2011-06-01 00:00:00

  • Open trial lamotrigine in the treatment of self-injurious behavior in an adolescent with profound mental retardation.

    abstract::This single case reports an open trial of lamotrigine in the treatment of self-injurious behavior (SIB) and epilepsy in an 18-year-old female diagnosed with generalized seizure disorder, stereotypic movement disorder, and compulsive SIB in the context of profound mental retardation. Animal models of SIB suggest that t...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1996.6.273

    authors: Davanzo PA,King BH

    更新日期:1996-01-01 00:00:00

  • Striatal volume abnormalities in treatment-naïve patients diagnosed with pediatric major depressive disorder.

    abstract:OBJECTIVE:The striatum, including the putamen and caudate, plays an important role in executive and emotional processing and may be involved in the pathophysiology of mood disorders. Few studies have examined structural abnormalities of the striatum in pediatric major depressive disorder (MDD) patients. We report stria...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2007.0026

    authors: Matsuo K,Rosenberg DR,Easter PC,MacMaster FP,Chen HH,Nicoletti M,Caetano SC,Hatch JP,Soares JC

    更新日期:2008-04-01 00:00:00

  • Clinical-Serological Characterization and Treatment Outcome of a Large Cohort of Italian Children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute Neuropsychiatric Syndrome.

    abstract:: Objective: Pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) are emerging immune-mediated encephalopathies characterized by sudden onset of seemingly inexplica...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0151

    authors: Lepri G,Rigante D,Bellando Randone S,Meini A,Ferrari A,Tarantino G,Cunningham MW,Falcini F

    更新日期:2019-10-01 00:00:00

  • Childhood inattention-overactivity, aggression, and stimulant medication history as predictors of young adult outcomes.

    abstract::This study examined the contributions of childhood symptom dimensions and aspects of methylphenidate (MPH) treatment to the prediction of young adult outcomes in boys who were referred to a child psychiatry outpatient clinic. They were diagnosed with hyperkinetic reaction of childhood/minimal brain dysfunction, and gi...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1999.9.169

    authors: Paternite CE,Loney J,Salisbury H,Whaley MA

    更新日期:1999-01-01 00:00:00

  • Acute myocardial infarction in a young male on methylphenidate, bupropion, and erythromycin.

    abstract::The prevalence and treatment of behavioral and mental illnesses in the adolescent population are increasing, and many of the medications used are continued into adulthood. Increased vigilance is necessary when caring for this population to prevent side effects and drug interactions. In this short communication, we pre...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2005.15.693

    authors: George AK,Kunwar AR,Awasthi A

    更新日期:2005-08-01 00:00:00

  • The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder.

    abstract:OBJECTIVES:Previous studies have suggested that the sum of Attention, Aggression, and Anxious/Depressed subscales of Child Behavior Checklist (CBCL-PBD; pediatric bipolar disorder phenotype) may be specific to pediatric bipolar disorder (BP). The purpose of this study was to evaluate the usefulness of the CBCL and CBCL...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2008.067

    authors: Diler RS,Birmaher B,Axelson D,Goldstein B,Gill M,Strober M,Kolko DJ,Goldstein TR,Hunt J,Yang M,Ryan ND,Iyengar S,Dahl RE,Dorn LD,Keller MB

    更新日期:2009-02-01 00:00:00

  • A Quantitative Comparison Approach for Methylphenidate Drug Regimens in Attention-Deficit/Hyperactivity Disorder Treatment.

    abstract:OBJECTIVE:Different methylphenidate (MPH) formulations, immediate release (IR) or extended release (ER), have been developed to treat Attention-Deficit/Hyperactivity Disorder (ADHD). A better use of these formulations, with a proper choice of their timing, dosage, and combination, can help to attain optimal therapeutic...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0093

    authors: Soufsaf S,Robaey P,Bonnefois G,Nekka F,Li J

    更新日期:2019-04-01 00:00:00

  • Persistence of stimulants in children and adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:To examine the persistence of three newly initiated stimulant preparations among Medicaid children and adolescents with attention-deficit/hyperactivity disorder (ADHD) diagnosis. METHODS:A retrospective longitudinal claims analysis was conducted by using Medicaid analytical eXtract data of four states. The s...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2011.0028

    authors: Palli SR,Kamble PS,Chen H,Aparasu RR

    更新日期:2012-04-01 00:00:00

  • Aripiprazole in children and adolescents with Tourette's disorder: an open-label safety and tolerability study.

    abstract:OBJECTIVE:The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD). METHOD:Eleven subjects (10 males) with TD (age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or wer...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2009.0035

    authors: Lyon GJ,Samar S,Jummani R,Hirsch S,Spirgel A,Goldman R,Coffey BJ

    更新日期:2009-12-01 00:00:00

  • Neuroanatomic comparison of bipolar adolescents with and without cannabis use disorders.

    abstract:OBJECTIVE:Co-occurrence of substance use and bipolar disorders is both common and associated with poor treatment response and greater functional impairment than either disorder alone. The neurophysiological correlates of this co-morbidity however, remain unclear. In this pilot study, we compared brain morphometry betwe...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2008.033

    authors: Jarvis K,DelBello MP,Mills N,Elman I,Strakowski SM,Adler CM

    更新日期:2008-12-01 00:00:00

  • Serotonin-selective reuptake inhibitor-induced enuresis in three pediatric cases.

    abstract::Although there are reports on their use for the treatment of enuresis, we present three pediatric cases with serotonin-selective reuptake inhibitor (SSRI)-induced enuresis. Because SSRIs continue to be commonly prescribed in the pediatric population, the need to monitor for the possibility of enuresis precipitated by ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.0070

    authors: Hergüner S,Kilinçaslan A,Görker I,Tüzün U

    更新日期:2007-06-01 00:00:00