Abstract:
:Gene selection is an important task in bioinformatics studies, because the accuracy of cancer classification generally depends upon the genes that have biological relevance to the classifying problems. In this work, randomization test (RT) is used as a gene selection method for dealing with gene expression data. In the method, a statistic derived from the statistics of the regression coefficients in a series of partial least squares discriminant analysis (PLSDA) models is used to evaluate the significance of the genes. Informative genes are selected for classifying the four gene expression datasets of prostate cancer, lung cancer, leukemia and non-small cell lung cancer (NSCLC) and the rationality of the results is validated by multiple linear regression (MLR) modeling and principal component analysis (PCA). With the selected genes, satisfactory results can be obtained.
journal_name
J Biomed Informjournal_title
Journal of biomedical informaticsauthors
Mao Z,Cai W,Shao Xdoi
10.1016/j.jbi.2013.03.009subject
Has Abstractpub_date
2013-08-01 00:00:00pages
594-601issue
4eissn
1532-0464issn
1532-0480pii
S1532-0464(13)00043-9journal_volume
46pub_type
杂志文章abstract::With rapid adoption of Electronic Health Records (EHR) in China, an increasing amount of clinical data has been available to support clinical research. Clinical data secondary use usually requires de-identification of personal information to protect patient privacy. Since manually de-identification of free clinical te...
journal_title:Journal of biomedical informatics
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doi:10.1016/j.jbi.2017.07.017
更新日期:2017-09-01 00:00:00
abstract::Automated software for cancer registration, called Open Registry and developed by ourselves was adopted by the Varese (population-based) Cancer Registry starting from 1997. Since the use of automated cancer registration is increasing, it is important to assess the quality and completeness of the automated data being p...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
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abstract::The importance of including patient preferences in decisions regarding their care has received increased emphasis over recent years. Medical informatics can play an important role in improving patient-centered care by developing decision support systems to support the inclusion of patient preferences in clinical decis...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
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abstract::Computers allow describing the progress of a disease using computerized models. These models allow aggregating expert and clinical information to allow researchers and decision makers to forecast disease progression. To make this forecast reliable, good models and therefore good modeling tools are required. This paper...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
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abstract::Health data exchange is a major challenge due to the sensitive information and the privacy issues entailed. Considering the European context, in which health data must be exchanged between different European Union (EU) Member States, each having a different national regulatory framework as well as different national h...
journal_title:Journal of biomedical informatics
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abstract::Corpora with specific entities and relationships annotated are essential to train and evaluate text-mining systems that are developed to extract specific structured information from a large corpus. In this paper we describe an approach where a named-entity recognition system produces a first annotation and annotators ...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2012.04.004
更新日期:2012-10-01 00:00:00
abstract::The Radiology Gamuts Ontology (RGO)-an ontology of diseases, interventions, and imaging findings-was developed to aid in decision support, education, and translational research in diagnostic radiology. The ontology defines a subsumption (is_a) relation between more general and more specific terms, and a causal relatio...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
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abstract::Hypotheses of homology are the basis of phylogenetic analysis. All character data are considered to be equivalent regardless of the source of those characters. Putative homology statements are designated based on observations of similarity. Pairwise sequence alignment using the Needleman-Wunsch algorithm is the basis ...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章,评审
doi:10.1016/j.jbi.2005.11.005
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abstract::Medical abuse refers to a type of abnormal medical practice which is not in compliance with qualitative or ethical standards, such as excessive prescription or overbilling of medical services. Detection of such medical abuses is crucial, especially for the patients and insurance providers, because they become subject ...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2009.03.004
更新日期:2009-06-01 00:00:00
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journal_title:Journal of biomedical informatics
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journal_title:Journal of biomedical informatics
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doi:10.1016/j.jbi.2017.04.011
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The association of genotyping information with common traits is not satisfactorily solved. One of the most complex traits is pain and association studies have failed so far to provide reproducible predictions of pain phenotypes from genotypes in the general population despite a well-established genetic basis...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2013.07.010
更新日期:2013-10-01 00:00:00
abstract::The 2014 i2b2/UTHealth natural language processing shared task featured a track focused on identifying risk factors for heart disease (specifically, Cardiac Artery Disease) in clinical narratives. For this track, we used a "light" annotation paradigm to annotate a set of 1304 longitudinal medical records describing 29...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2015.05.009
更新日期:2015-12-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2012.07.010
更新日期:2012-12-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2013.06.001
更新日期:2013-10-01 00:00:00
abstract::Game-based interventions (GBI) have been used to promote health-related outcomes, including cognitive functions. Criteria for game-elements (GE) selection are insufficiently characterized in terms of their adequacy to patients' clinical conditions or targeted cognitive outcomes. This study aimed to identify GE applied...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2019.103287
更新日期:2019-10-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章,评审
doi:10.1016/j.jbi.2019.103141
更新日期:2019-05-01 00:00:00
abstract::To improve the performance of Intensive Care Units (ICUs), the field of bio-statistics has developed scores which try to predict the likelihood of negative outcomes. These help evaluate the effectiveness of treatments and clinical practice, and also help to identify patients with unexpected outcomes. However, they hav...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2019.103269
更新日期:2019-10-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2015.06.015
更新日期:2015-12-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2017.07.013
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:One of the major concerns of the biomedical community is the increasing prevalence of antimicrobial resistant microorganisms. Recent findings show that the diversification of colony morphology may be indicative of the expression of virulence factors and increased resistance to antibiotic therapeutics. To tra...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2015.03.007
更新日期:2015-06-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2017.03.004
更新日期:2017-05-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jbi.2016.04.001
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether SNOMED CT covers the terms used in pre-operative assessment guidelines, and if necessary, how the measured content coverage can be improved. METHODS:Pre-operative assessment guidelines were retrieved from the websites of (inter)national anesthesia-related societies. The recommendations...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2010.07.009
更新日期:2010-12-01 00:00:00
abstract::With the rise in chronic, behavior-related disease, computerized behavioral protocols (CBPs) that help individuals improve behaviors have the potential to play an increasing role in the future health of society. To be effective and widely used CBPs should be based on accepted behavioral theory. However, designing CBPs...
journal_title:Journal of biomedical informatics
pub_type: 临床试验,杂志文章
doi:10.1016/j.jbi.2004.12.001
更新日期:2005-08-01 00:00:00
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journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1006/jbin.2001.1004
更新日期:2001-02-01 00:00:00
abstract:STUDY OBJECTIVE:The goals of this investigation were to study the temporal relationships between the demands for key resources in the emergency department (ED) and the inpatient hospital, and to develop multivariate forecasting models. METHODS:Hourly data were collected from three diverse hospitals for the year 2006. ...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2008.05.003
更新日期:2009-02-01 00:00:00
abstract::In Electronic Health Records (EHRs), much of valuable information regarding patients' conditions is embedded in free text format. Natural language processing (NLP) techniques have been developed to extract clinical information from free text. One challenge faced in clinical NLP is that the meaning of clinical entities...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2015.02.010
更新日期:2015-04-01 00:00:00
abstract::Dialogue systems for health communication hold out the promise of providing intelligent assistance to patients through natural interfaces that require no training to use. But in order to make the development of such systems cost effective, we must be able to use generic techniques and components which are then special...
journal_title:Journal of biomedical informatics
pub_type: 杂志文章
doi:10.1016/j.jbi.2006.02.004
更新日期:2006-10-01 00:00:00