Homology assessment and molecular sequence alignment.

Abstract:

:Hypotheses of homology are the basis of phylogenetic analysis. All character data are considered to be equivalent regardless of the source of those characters. Putative homology statements are designated based on observations of similarity. Pairwise sequence alignment using the Needleman-Wunsch algorithm is the basis for similarity maximization between molecular sequences. Multiple sequence alignment uses this algorithm in a topologically hierarchical framework. The resulting hypotheses of homology are tested in conjunction with character congruence through parsimony. This review introduces some underlying principles of phylogenetic analysis as they pertain homology testing and DNA sequence alignment.

journal_name

J Biomed Inform

authors

Phillips AJ

doi

10.1016/j.jbi.2005.11.005

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

18-33

issue

1

eissn

1532-0464

issn

1532-0480

pii

S1532-0464(05)00130-9

journal_volume

39

pub_type

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