Abstract:
BACKGROUND:Multifactor neuropathic pain is one of the most frequent symptoms in AIDS patients and analgesic treatment is primarily based on the use of drug combination of opioids, tricyclic antidepressants and antiepileptics. However, the chronic use of opioids in AIDS patients presents a risk due to the immunosuppressive action of these drugs. Until now, buprenorphine has been regarded as one of the safest opioid analgesics for the treatment of patients with compromised immune systems. To assess the suitability of transdermal fentanyl for the treatment of neuropathic pain in AIDS patients, the present study compares the efficacy, tolerability and the immunosuppressive effects of transdermal buprenorphine vs. fentanyl. METHODS:Forty advanced AIDS patients (28 male and 12 female) with chronic peripheral neuropathic pain were enrolled onto this clinical trial. Neuropathic pain was assessed for its constituent types of pain (burning, stabbing and shooting), its overall intensity and allodynia; scores were awarded using the Neuropathic Pain Scale, expressed as 10 item VAS scores. RESULTS:Both treatment groups showed statistically significant reductions in each of the individual types of neuropathic pain and allodynia (P<0.05; 95% CI: -14.7, -3.1) and significant improvements in Karnofsky Performance Status (P<0.05; mean value, 69; range: 40-90). Both buprenorphine and fentanyl were well tolerated. Neither buprenorphine nor fentanyl affected CD4+ or CD8+levels and both treatments, but particularly buprenorphine group, resulted in more stable CD4+ concentrations. CONCLUSION:The high efficacy, tolerability and patient compliance of both buprenorphine and fentanyl make both these two opioids valid therapeutic options for the treatment of neuropathic pain in patients with AIDS.
journal_name
Minerva Anestesioljournal_title
Minerva anestesiologicaauthors
Canneti A,Luzi M,Di Marco P,Cannata F,Pasqualitto F,Spinoglio A,Reale Csubject
Has Abstractpub_date
2013-08-01 00:00:00pages
871-83issue
8eissn
0375-9393issn
1827-1596pii
R02138140journal_volume
79pub_type
杂志文章abstract::Results obtained with Althesin as anaesthetic in 100 patient subjected to urological surgery are presented. The continuous perfusion of Althesin gave a level of stable and flexible anaesthesia that, like the return to consciousness, was particularly appreciated by aged patients. Stress is laid on the fact that the har...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:The aim was to investigate whether tramadol had toxic effect on cerebral neurons and/or spinal cord neurons when it was administered into the cerebrospinal fluid. Due to lipid peroxidation (LPO) and myeloperoxidation (MPO) levels are not specific predictors of neuronal damage, these biochemical markers of ti...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
abstract::An original technique of analgesic anaesthesia, with the characteristics of brief and out-clinic anaesthesia, has been experimented in a group of patients undergoing light surgery (eye surgery). The technique employs an association of an analgesic--Fentanil--a low dose hypnotic and marked hyperventilation. Recovery ch...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Devices that limit microaspiration through the cuffs of endotracheal tubes could help prevent ventilator-associated pneumonia (VAP). The amount of tracheal microaspirations could be a relevant study endpoint. The aim of our study was to assess whether amylase measured in tracheal secretions constituted a rel...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::In this paper the Authors describe the anesthetic techniques used for abdominal surgery in a 19 year-old woman with "central-core disease". This uncommon congenital neuromuscular disorder is frequently related to malignant hyperthermia syndrome. Total intravenous anesthesia with the association propofol-fentanyl was w...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:AIM:Inguinal herniorrhaphy (IH) is a common surgical procedure that can be successfully performed by using general, regional or local anesthesia and is usually performed in an outpatient setting. In this study, recovery profile, incidence of adverse effects, postoperative pain scores and patient satisfaction between pa...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2009-12-01 00:00:00
abstract::Excessive adrenergic stimulation may be associated with several adverse events and contribute to increase mortality in critically ill septic patients. Few clinical data exist on the effects of adrenergic blockade in this setting. The objective of this study was to investigate the effect of a short acting b-blocker (es...
journal_title:Minerva anestesiologica
pub_type: 评论,杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::Transthoracic thermodilution (TTT) measures cardiac output without the need for right heart catheterization. In addition, two volumetric hemodynamic indices have been derived from the mathematical analysis of the TTT curve: the global end diastolic volume (a quantitative measure of cardiac preload) and the extravascul...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The characteristics of sevoflurane make it able to be used without N2O avoiding its undesirable effects to this associates. The aim of the study is to evaluate the clinical characteristics of sevoflurane anesthesia "N2O free" in comparison to sevoflurane anesthesia with N2O. METHODS:920 patient undergoing e...
journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2000-09-01 00:00:00
abstract::Neuroleptic malignant syndrome (NMS) in its most severe form ranging from disorders of consciousness to coma is now reported relatively frequently in intensive care journals. Having observed such a case in the intensive care ward of their hospital, the Authors investigate the possibility of differential diagnosis betw...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::In the last decade, there has been increasing use of the da Vinci® robot surgical system to perform minimally invasive thoracic surgery. The robotic technology can be applied for surgery of the lungs, mediastinum, and esophagus. A number of case reports have been shown steep learning curve, and promising surgical outc...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2014-01-01 00:00:00
abstract::Acute lung failure is associated with high mortality and usually requires mechanical ventilation to ensure adequate gas exchange. However, mechanical ventilation itself can be associated with major complications and can aggravate pre-existing lung disease, thus contributing to morbidity and mortality. Extracorporeal g...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence of colonization and infection by methicillin-resistant in PICU. DESIGN:Prospective cohort study during 2 years for the surveillance of nosocomial infections. SETTING:Four beds Pediatric Intensive Care Unit. PATIENTS:We studied two-hundred patients with duration of hospitalization ...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::The authors report two clinical cases of Guillain-Barré syndrome, treated with contemporaneous use of plasmapheresis and high dose gammaglobulin. An early diagnosis and immediate application of such a therapeutic association, are of paramount importance in order to obtain remission of the neurologic symptomatology wit...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::A case of severe accidental hypothermia (core temperature 20 degrees C) in an elderly woman successfully treated by warmed lavage of peritoneal cavity is reported. The various available rewarming techniques and some observations about the differential diagnosis between the severe hypothermic patient with cardiac arres...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::A correct assessment of arterial pressure state during SAH is one of most critical issue in neurologic intensive care. It is important to evaluate two different clinical conditions: a) during SAH when the aneurysm is open, b) after aneurysmal clipping or embolization. The authors propose pressure parameters appropriat...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::The authors analyze the physiological basis, technical aspects and clinical usefulness of several methods for pressure-volume curves determinations in mechanically ventilatory, acute respiratory failure patients. ...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The aim of the study was to investigate whether or not sevoflurane at different concentrations influenced the ED(effective dose) 50, 90 and 95 of cisatracurium and whether there is any relationship with age. METHODS:Individual dose response curves for cisatracurium were constructed in 80 consecutive patient...
journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-03-01 00:00:00
abstract::The Authors, after a brief review of malignant hyperthermia (MH), describe the use of NLA a Harrington's surgical procedure in a malignant hyperthermia susceptible (MHS) patient. Such an anaesthesiological procedure, using benzodiazepines, droperidol, fentanyl, pancuronium and N2O/O2, didn't lead to any form of MH cri...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::TOSS, together with severity of illness (SAPS) and intensity of processes (TISS), has been determined in 941 patients on the 9th day of ICU stay, to ascertain the validity of TOSS in the calculation of the nurse/patient ratio, not only at the time of admission to ICU but also during the stay. The mean values of all in...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,多中心研究
doi:
更新日期:1992-12-01 00:00:00
abstract:INTRODUCTION:The world population is mostly male at birth, although there is a shift in predominance over 55 years of age with more females than males. Male gender was recently hypothesized to be a risk factor for sepsis and septic shock; the reasons and the consequences of this odd discrepancy are yet a matter of deba...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:10.23736/S0375-9393.17.12187-5
更新日期:2018-04-01 00:00:00
abstract::Postoperative pain management an important clinical issue. The clinicians tool-bag remains incomplete. Improvements in the management of postoperative pain will ultimately translate into the broader, safer application of surgical procedures upon a wider patient population. The application of multimodal therapy that in...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2006-03-01 00:00:00
abstract:AIM:Heat shock proteins (HSPs), induced by thermal stress, make the cells more resistant to following stress. We aimed to verify if rats heating reduces the production of TNF-alpha in a model of acute respiratory distress syndrome (ARDS). METHODS:We divided 34 Wistar rats in Group A and Group B. The rats of Group A re...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::Multimodal pain management, combining analgesics with different mode of action in order to minimize occurrence of side-effects still providing safe and efficacious pain management after ambulatory surgery has become standard of care. The combined use of local anaesthesia in order to reduce noxious influx during the pr...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Ultrasound is a portable and safe technology that is increasingly used to assist anesthetic procedures and has been integrated into the routine practice of a wide range of invasive procedures. As a complementary diagnostic tool, publications related to perioperative support other than vascular access and n...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:10.23736/S0375-9393.17.12178-4
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Disorders in cerebral circulation following elevated intra-abdominal pressure (IAP) may lead to silent brain ischemia, which can be serious problem in sedated critically ill patients. The aim of the present study was to analyse the possible association between jugular venous bulb pressure (JVBP) and jugular ...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:2014-07-01 00:00:00
abstract::In order to avoid complications such as pneumothorax or subarachnoid injection, the paper proposes a new approach to brachial plexus using a supraclavear route based on the pulse of the subclavian artery and 7th cervical vertebra. Complications are unlikely using this route. ...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::The anaesthetic technique chosen for a laparohysterectomy in a woman affected by Apert's acrocephalosyndactilia is described. Difficulties in performing tracheal intubation were overcome by mean of loco-regional anesthesia (LRA). In order to minimize the anaesthetic risk, a standardised preoperative evaluation and ass...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::A prolonged electrocardiographic QTc interval may be unsafe during general anesthesia; thus successful anesthetic management in patients affected by congenital long QT syndrome include avoidance of any event that increases sympathetic activity and drugs that prolong QT interval. Propofol seems to have less effect on t...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the cerebral blood flow parameters assessed by transcranial Doppler during aortic cross-clamping and unclamping in patients undergoing abdominal aortic aneurysmectomy. METHODS:Invasive intraoperative monitoring of mean arterial pressure (MAP) and PaCO2, and right middle cerebral artery (RMCA) mon...
journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-03-01 00:00:00