Abstract：
BACKGROUND:The aim of the study was to investigate whether or not sevoflurane at different concentrations influenced the ED(effective dose) 50, 90 and 95 of cisatracurium and whether there is any relationship with age. METHODS:Individual dose response curves for cisatracurium were constructed in 80 consecutive patients randomly assigned to four groups: group 1 TIVA with fentanyl and propofol; group 2, 3 and 4 sevoflurane 1, 1.5, 2 MAC respectively, MAC age adjusted and with N2O 65%. Patients were premedicated with diazepam and induction accomplished with fentanyl (1.5-2 micrograms/kg) and propofol (1.5-2 mg/kg); following intubation with succinylcholine (0.4 mg/kg), TIVA or sevoflurane at the desired MAC was maintained until equilibration occurred and then cisatracurium administered in 8-10 micrograms/kg boluses until the attainment of ED95. Neuromuscular monitoring utilized TOF stimulation and ratio evaluation between Ist twitch of the train and basal twitch (T1/Tc) and continuous recording of accelerometry (Tof-guard). Single dose response curves were analyzed with sigmoid equations; the Eds and other parameter means were subjected to analysis of variance for parametric and non parametric data. RESULTS:More boluses were required under TIVA and sevo 1 MAC anesthesia (8.3 and 7.1 vs 4.9 of sevo 1.5 and 2 MAC); maximal depression (94.95%) was reached more frequently with sevo, while under TIVA an average 90% depression only was obtained. Mean ED50 (microgram/kg) where 22 (sevo) vs 34 (TIVA): ED90 averaged 36 (sevo) vs 53 (TIVA); ED95 averaged 39 (sevo) vs 56 (TIVA), with significant differences (p < 0.05) between Eds obtained from TIVA group in comparison with sevoflurane groups, but without differences between averaged EDs obtained with different MAC values among sevoflurane groups. The investigation of the relationship between age and Eds demonstrated a linear regression for all groups considered together (p = 0.000) for all Eds (50, 90, 95). CONCLUSIONS:In conclusion, the presence of MAC multiples of sevoflurane potentiated only slightly the dosages of cisatracurium and EDs linearly increase with age, particularly under sevoflurane anesthesia.
journal_name
Minerva Anestesioljournal_title
Minerva anestesiologicaauthors
Melloni C,Antolini Fkeywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
115-21; discussion 121-2issue
3eissn
0375-9393issn
1827-1596journal_volume
66pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:The coronary sinus oxygen saturation (SO2) can affect the oxygen saturation of the superior vena cava (superior cava SO2) and the pulmonary artery (pulmonary artery SO2), causing a gradient between the latter two (ΔSO2), as has been observed in different physiological and pathological conditions. The objecti...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To set up an index for the evaluation of type of interventions and procedures applied a prerequisite for the evaluation of appropriateness of ICU's activity. DESIGN:Observation prospective study. PATIENTS:2507 patients out of the 5030 enrolled in the cohort study. MEASUREMENTS:A cross-sectional assessment ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:Labile iron is important in the pathogenesis of acute kidney injury (AKI). Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress. However, higher levels of urinary NGAL are associated with AKI severity whereas higher urinary hepcidin le...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：:The successful management of a case of primary hypothyroidism, who underwent hemicolectomy, is described. Anaesthesia was induced with TPS and maintained with only isoflurane. Neuromuscular blockade was achieved by atracurium. Hemodynamic, respiratory and neuromuscular monitoring was performed. This complex intraopera...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Recently, efforts have been undertaken to investigate the effects of thrombolysis during cardiopulmonary resuscitation (CRP) in patients suffering from massive pulmonary embolism or acute myocardial infarction. In up to 70% of patients with cardiac arrest, one of these two diseases is the underlying cause of deteriora...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:It is common practice to administer a premedication to patients about to undergo anesthesia. This study compared the effects of a small intravenous bolus of propofol versus midazolam administered as a premedication. METHODS:In this prospective, randomized, double-blind, placebo-controlled study, 60 healthy ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-05-01 00:00:00
abstract：:The overall use of allogeneic blood transfusions in clinical practice remains relatively high and still varies widely among centres and practitioners. Moreover, allogeneic blood transfusions have historically been linked with risks and complications: some of them (e.g. transfusion reactions and transmission of pathoge...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-10-01 00:00:00
abstract：AIM:Inguinal herniorrhaphy (IH) is a common surgical procedure that can be successfully performed by using general, regional or local anesthesia and is usually performed in an outpatient setting. In this study, recovery profile, incidence of adverse effects, postoperative pain scores and patient satisfaction between pa...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-12-01 00:00:00
abstract：AIM:The aim of this study was to evaluate and compare the parameters for mechanical respiration in pediatric patients undergoing controlled ventilation with a laryngeal mask (LM) and an uncuffed orotracheal tube. METHODS:The study examined 100 ASA 1 patients undergoing general anesthesia with myoresolution and mechani...
journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the usefulness of the modified Harris-Benedict formula predicting Energy Expenditure (EE) in pressure support ventilated, critically ill patient. SETTING:The intensive care unit (ICU) of a teaching hospital. PATIENTS:Fiftyfive patients admitted to ICU for acute respiratory failure, requiring mec...
journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:In 61 patients submitted to subdural anesthesia for orthopedic operations, postoperative somatic pain was treated by double-blind iv injection of lysine acetylsalicylate 1.8 g or placebo randomly. Patients with persistent pain received methadone 10 mg im. No placebo response was obtained; LAS had similar but shorter e...
journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1981-05-01 00:00:00
abstract：:Primary Acute Lung Injury (ALI) after lung resection (or "post-pneumonectomy pulmonary edema") is a rare form of acute respiratory failure characterized by dyspnea, hypoxemia, diffuse infiltrates on chest radiogram, and rapid evolution often unresponsive to therapy. ALI occurs almost exclusively following pneumonectom...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：:A 74-year-old patient was submitted to urgent surgery for intestinal occlusion. After the induction of the anaesthesia, tracheal intubation failed since no progression of Eshmann tracheal tube introducer was possible. The ventilation was difficult and a laryngeal mask was inserted. After oxygenation, the tracheal tube...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:Humoral immunity (immunoglobulins and C3) as well as nutritional conditions (serum albumin, transferrin) have been investigated in 23 patients in the acute phase after surgery and/or trauma. Immunoglobulin deficiency, well correlated with the severity of trauma, was observed in the most critically ill patients in the ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:Despite consistent improvement in its treatment, amatoxin poisoning still extolls an elevated overall mortality, ranging between 10 and 15%, which approaches 100% when severe (grade 3-4 encephalopathy) hepatic failure supervened. Therefore, the proper treatment of intoxication by amatoxin containing mushrooms, and par...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：AIM:The study compares the intraoperative effects of combined versus general anesthesia during major liver surgery. METHODS:In this prospective randomized study, 70 patients were divided into 2 group of 35 subjects. Group A received general anesthesia (thiopentone, fentanyl, vecuronium, sevoflurane in a closed circuit...
journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-12-01 00:00:00
abstract：:Accidents during anaesthesia may be clinical or technical. To avoid the latter, stress is laid on the by no means new concept that techniques and handling must fit contingent requirements and that they may be dangerous as much for their inadequate as for their excessive use. ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Arrhythmias are common in hospitalized patients and during surgery. We present a case of positional atrial arrhythmia related to a peripherally inserted central catheter (PICC). There are other documented case reports of ventricular tachycardia precipitated by body position changes with a PICC. The immediate correctio...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:A case of pulmonary edema secondary to dislocation of laryngeal mask during awakening from anesthesia is described. The complication has been ascribed to physiopathological changes of the alveolo-capillary membrane caused by inspiratory efforts secondary to dislocation of laryngeal mask during awakening from anesthesi...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:More and more evidence accumulates suggesting that the reversal of the catabolic responses to surgery is associated with better outcome. The potential for anesthesiologists to be involved in altering outcome by simply preserving a normal blood glucose, providing optimal pain control and perioperative feeding is tremen...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:No data are available on the perioperative approach during orthotopic liver transplantation (OLT) in Italy, apart from sporadically single center studies. METHODS:The Department of Anesthesia cooperating with each Italian licensed OLT center received a questionnaire regarding preoperative evaluation, intrao...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：:Worldwide about 1 in 1000 adults every year has a sudden cardiac arrest in out-of-hospital. That means 350,000-400,000 persons in the USA alone, 60,000 persons in Italy. Over 70% of times sudden cardiac arrest occurs at home, the remaining 30% in public settings. The chain of survival concept emphasizes four links ass...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Multiple organ dysfunction can occur in patients undergoing Veno-arterial Extra Corporal Membrane Oxygenation (VA-ECMO); however, liver function has not been well studied in this setting. METHODS:In a review of our institutional ECMO database (n=162), we collected aspartate (AST) and alanine (ALT) transamin...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：10.23736/S0375-9393.16.11442-7
更新日期：2017-03-01 00:00:00
abstract：:Xenon is an interesting anesthetic as it appears to lack negative inotropicy and vasodilatation, giving great advantages to both patients with limited cardiovascular reserve or those who require hemodynamic stability. It has low toxicity and is not teratogenic. Xenon gives rapid induction and recovery, due to its low ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Few studies have investigated the incidence of pulmonary anaerobes in a specific population in surgical Intensive Care Unit (ICU). The objective of this work was to determine the incidence of anaerobes in surgical ICU patients with suspected pneumonia. METHODS:This was a prospective observational, single-ce...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:The study aimed to compare Bispectral Index (BIS) and non-BIS anesthetic protocols on postoperative recovery outcomes. EVIDENCE ACQUISITION:Medline, PubMed, Cochrane, EMBASE, and Google Scholar databases were searched until January 21, 2016. EVIDENCE SYNTHESIS:Twenty-six studies were included with a tota...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：10.23736/S0375-9393.17.12033-X
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Pneumonia is the primary source of sepsis and is significantly associated with mortality. However, only a few studies focus on its clinical characteristics and outcomes. METHODS:We evaluated 500 intensive care unit patients who met severe sepsis or septic shock criteria, dividing them into two distinct grou...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,多中心研究
doi：
更新日期：2013-12-01 00:00:00
abstract：:Chronic musculoskeletal pain is a highly prevalent condition that is commonly encountered in both general and specialist practice. Nonetheless, it still represents a significant challenge to the practitioners because of the lack of substantial evidence-based guidance. This review aimed to summarize the main pathophysi...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：10.23736/S0375-9393.20.14573-5
更新日期：2020-12-01 00:00:00
abstract：:Ahead of Print article withdrawn by publisher Blood brain barrier disruption (BBBD) is a novel technique for treating central nervous system lymphoma. This technique depends on the disruption of the tight junctions between endothelial cells (which represent the blood brain barrier) by intra-arterial injection of manni...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2011-10-21 00:00:00
abstract：BACKGROUND:The goal of this paper was to investigate the association between patterns of intracranial hypertension (IH) and outcomes, to describe the treatment of patients with different patterns of IH, and to examine whether IH is an independent predictor of mortality and unfavourable outcome, respectively. METHODS:A...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
