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Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4.

Abstract：

:Myasthenia gravis is caused by antibodies to the acetylcholine receptor, muscle-specific kinase, low-density lipoprotein receptor-related protein 4, or possibly yet unidentified antibodies. The mechanisms by which these antibodies interfere with the function of postsynaptic proteins include complement activation, antigenic modulation by crosslinking of the target proteins, competition with ligand binding sites, or steric hindrance which inhibits conformational changes or binding to associated proteins. Screening for auto-antibodies to different postsynaptic targets, and also for low-affinity antibodies, is contributing to a more accurate diagnosis of MG patients. Further studies into the specific pathophysiological pathways of the several MG subforms might help to develop new, more antigen specific, therapies.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Verschuuren JJ,Huijbers MG,Plomp JJ,Niks EH,Molenaar PC,Martinez-Martinez P,Gomez AM,De Baets MH,Losen M

doi

10.1016/j.autrev.2013.03.001

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

918-23

issue

9

eissn

1568-9972

issn

1873-0183

pii

S1568-9972(13)00027-X

journal_volume

12

pub_type

杂志文章,评审

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