COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?

Abstract:

:The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndromes" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and "hyperferritinemic syndromes" are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and "hyperferritinemic syndromes" which would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Colafrancesco S,Alessandri C,Conti F,Priori R

doi

10.1016/j.autrev.2020.102573

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

102573

issue

7

eissn

1568-9972

issn

1873-0183

pii

S1568-9972(20)30135-X

journal_volume

19

pub_type

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