Abstract:
:The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndromes" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and "hyperferritinemic syndromes" are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and "hyperferritinemic syndromes" which would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Colafrancesco S,Alessandri C,Conti F,Priori Rdoi
10.1016/j.autrev.2020.102573subject
Has Abstractpub_date
2020-07-01 00:00:00pages
102573issue
7eissn
1568-9972issn
1873-0183pii
S1568-9972(20)30135-Xjournal_volume
19pub_type
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