Abstract:
:Statistical methodologies for human abuse potential studies are rarely evaluated. Human abuse potential studies assess whether test drugs produce positive and negative subjective responses on abuse-related measures using volunteers with histories of recreational drug use. These studies typically have a randomized, double-blind, placebo- and positive-controlled crossover design with at least four treatments: placebo, at least two doses of a test drug, and at least one dose of a positive control drug (a drug with known abuse potential). This article proposes a new test for assessing whether a test drug produces data indicative of abuse potential when compared to placebo.
journal_name
J Biopharm Statjournal_title
Journal of biopharmaceutical statisticsauthors
Chen L,Bonson KRdoi
10.1080/10543406.2011.616972subject
Has Abstractpub_date
2013-03-11 00:00:00pages
294-306issue
2eissn
1054-3406issn
1520-5711journal_volume
23pub_type
杂志文章abstract::Patient-reported outcomes are important for assessing the effectiveness of treatments in many disease areas. For this reason, many new instruments that capture patient-reported outcomes have been developed over the past several decades. With the development of each new instrument, there is the ensuing question of what...
journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 临床试验,杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章,评审
doi:10.1080/10543409108835004
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
doi:10.1080/10543406.2014.971165
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pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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