Abstract:
:An ability to predict the metabolic fate of a drug is important to drug design. Programs for predicting drug metabolites are becoming available, as are databases that will facilitate the development of such programs. Objective analysis of the performance of these programs will require statistical methods. The development of appropriate statistical methods must address a fundamental data representation problem that arises from the fact that the basic metabolic information uses chemical graph representations rather than the usual vector representations that typify statistical methodology. This study addresses the representation problem by using concepts arising from molecular similarity analysis. The statistical methods that are developed are illustrated by evaluating the performance of MetabolExpert in predicting the metabolic fate of benzodiazepines.
journal_name
J Biopharm Statjournal_title
Journal of biopharmaceutical statisticsauthors
Johnson Mdoi
10.1080/10543409108835004subject
Has Abstractpub_date
1991-01-01 00:00:00pages
27-56issue
1eissn
1054-3406issn
1520-5711journal_volume
1pub_type
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
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doi:10.1080/10543406.2013.736810
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
doi:10.1080/10543406.2018.1489401
更新日期:2018-01-01 00:00:00
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章,评审
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章,评审
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journal_title:Journal of biopharmaceutical statistics
pub_type: 杂志文章
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