Abstract:
:In preclinical tumor xenograft experiments, the antitumor activity of the tested agents is often assessed by endpoints such as tumor doubling time, tumor growth delay (TGD), and log10 cell kill (LCK). In tumor xenograft literature, the values of these endpoints are presented without any statistical inference, which ignores the noise in the experimental data. However, using exponential growth models, these endpoints can be quantified by their growth curve parameters, thus allowing parametric inference, such as an interval estimate, to be used to assess the antitumor activity of the treatment.
journal_name
J Biopharm Statjournal_title
Journal of biopharmaceutical statisticsauthors
Wu Jdoi
10.1080/10543406.2010.481802subject
Has Abstractpub_date
2011-05-01 00:00:00pages
472-83issue
3eissn
1054-3406issn
1520-5711pii
935353087journal_volume
21pub_type
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journal_title:Journal of biopharmaceutical statistics
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