A semi-mechanistic model of the relationship between average glucose and HbA1c in healthy and diabetic subjects.

abstract：:There are situations in drug development where one may wish to reduce the dimensionality and complexity of whole body physiologically based pharmacokinetic models. A technique for formal reduction of such models, based on global sensitivity analysis, is suggested. Using this approach mean and variance of tissue(s) and...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gueorguieva I,Nestorov IA,Rowland M

更新日期：2006-02-01 00:00:00

abstract：:There has been little evaluation of maximum likelihood approximation methods for non-linear mixed effects modelling of count data. The aim of this study was to explore the estimation accuracy of population parameters from six count models, using two different methods and programs. Simulations of 100 data sets were per...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Plan EL,Maloney A,Trocóniz IF,Karlsson MO

更新日期：2009-08-01 00:00:00

abstract：:Cancer therapies that harness the actions of the immune response, such as targeted monoclonal antibody treatments and therapeutic vaccines, are relatively new and promising in the landscape of cancer treatment options. Mathematical modeling and simulation of immune-modifying therapies can help to offset the costs of d...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： dePillis LG,Eladdadi A,Radunskaya AE

更新日期：2014-10-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) represent a therapeutic strategy that has been increasingly used in different diseases. mAbs are highly specific for their targets leading to induce specific effector functions. Despite their therapeutic benefits, the presence of immunogenic reactions is of growing concern. The immunogenic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gómez-Mantilla JD,Trocóniz IF,Parra-Guillén Z,Garrido MJ

更新日期：2014-10-01 00:00:00

abstract：:The physiologically based pharmacokinetic (PBPK) models allow for predictive assessment of variability in population of interest. One of the future application of PBPK modeling is in the field of precision dosing and personalized medicine. The aim of the study was to develop PBPK model for amitriptyline given orally, ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tylutki Z,Mendyk A,Polak S

更新日期：2018-10-01 00:00:00

abstract：:We explore the use of fractional order differential equations for the analysis of datasets of various drug processes that present anomalous kinetics, i.e. kinetics that are non-exponential and are typically described by power-laws. A fractional differential equation corresponds to a differential equation with a deriva...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Macheras P

更新日期：2009-04-01 00:00:00

abstract：:Although selective 5-HT reuptake inhibitors (SSRIs) block monoamine uptake within hours of administration to patients, their full clinical effect does not appear until 2-4 weeks after treatment onset. Pindolol, a betablocker with weak partial 5-HT1A receptor agonist activity has been shown to produce a more rapid onse...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gruwez B,Dauphin A,Tod M

更新日期：2005-12-01 00:00:00

abstract：:Significant arterio-venous differences in nicotine concentrations have been observed during and after cigarette smoking, nicotine nasal spray, and intravenous nicotine administration. In this paper we describe a novel mathematical method for estimating arterial blood levels from venous blood level data. The model allo...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pitsiu M,Gries JM,Benowitz N,Gourlay SG,Verotta D

更新日期：2002-08-01 00:00:00

abstract：:The volume of distribution at steady state (Vss) of therapeutic proteins is usually assessed by non-compartmental or compartmental pharmacokinetic (PK) analysis wherein errors may arise due to the elimination of therapeutic proteins from peripheral tissues that are not in rapid equilibrium with the sampling compartmen...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Richter WF,Grimm HP,Theil FP

更新日期：2011-10-01 00:00:00

abstract：:In the present pharmacokinetic/pharmacodynamic (PK/PD) evaluation, cortisol, total lymphocytes, and lymphocyte subpopulations were monitored following single oral doses of two oral formulations of 3 mg budesonide (BUD) (Dosage Forms A and B) in order to assess the differential effects that BUD may have on cortisol sup...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Stark JG,Werner S,Homrighausen S,Tang Y,Krieg M,Derendorf H,Moellmann H,Hochhaus G

更新日期：2006-08-01 00:00:00

abstract：:We develop a mechanistic model for post-operative pain and apply it to describe the pharmacodynamic effects of the kappa-opioids nalbuphine and naloxone administered either alone or in combination in patients after surgical removal of one or more madibular third molar teeth. Data were obtained from 6 clinical studies ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kshirsagar S,Gear R,Levine J,Verotta D

更新日期：2008-02-01 00:00:00

abstract：:Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Wiczling P,Gebre A

更新日期：2017-08-01 00:00:00

abstract：:Pharmacokinetic analysis in humans using compartmental models is restricted with respect to the estimation of parameter values. This is because the experimenter usually is only able to apply inputs and observations in a very small number of compartments in the system. This has implications for the structural identifia...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cheung SY,Yates JW,Aarons L

更新日期：2013-02-01 00:00:00

abstract：:This study aimed to characterize pharmacodynamic interaction between propofol and aminophylline. Nine beagle dogs were randomly allocated at the propofol rates of 0.75 (group A), 1.00 (group B), and 1.25 (group C) mg/kg/min. During period 1, propofol only was infused, while during period 2, aminophylline only, at the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lee SH,Kang HJ,Jin SJ,Park DY,Choi YJ,Choi BM,Lee EK,Noh GJ

更新日期：2014-12-01 00:00:00

abstract：:Minimal physiologically based pharmacokinetic (mPBPK) models provide a simple and sensible approach that incorporates physiological elements into pharmacokinetic (PK) analysis when only plasma data are available. With this modeling concept, a second-generation mPBPK model was further developed with specific accommodat...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cao Y,Jusko WJ

更新日期：2014-12-01 00:00:00

abstract：:This study was designed to investigate the pharmacokinetics/pharmacodynamics (PK/PD) risk factors preceding the onset of type 2 diabetes using a population-based Bayesian nonlinear hierarchical model to describe the glucose-insulin kinetics. One hundred fifty-two healthy subjects with a family history of type 2 diabet...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lin CW,Veng-Pedersen P

更新日期：2009-10-01 00:00:00

abstract：:This study was designed to investigate ethnic differences in the pharmacokinetics (PKs) of moxifloxacin and its metabolites, M1 (sulfo conjugate) and M2 (acyl-glucuronate), among Japanese, Chinese, and Korean populations, following oral administration. We used a population PK modeling approach using data from a clinic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaneko M,Aoyama T,Ishida Y,Miyamoto A,Saito Y,Tohkin M,Kawai S,Matsumoto Y

更新日期：2018-04-01 00:00:00

abstract：:Population pharmacokinetic-pharmacodynamic analysis involves nonlinear hierarchical modelling where the mean response in a population and the variability in response from different sources are studied. It generally consists of two model hierarchies: a model for residual error and a model for heterogeneity termed betwe...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lagishetty CV,Vajjah P,Duffull SB

更新日期：2012-08-01 00:00:00

abstract：:To solve the problem of estimating an unknown input function to a linear time invariant system we propose an adaptive non-parametric method based on reversible jump Markov chain Monte Carlo (RJMCMC). We use piecewise polynomial functions (splines) to represent the input function. The RJMCMC algorithm allows the explor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kang D,Verotta D

更新日期：2007-06-01 00:00:00

abstract：:Mathematical modeling of drug effects maximizes the information gained from an experiment, provides further insight into the mechanisms of drug effects, and allows for simulations in order to design studies or even to derive clinical treatment strategies. We reviewed modeling of antimicrobial drug effects and show tha...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Czock D,Keller F

更新日期：2007-12-01 00:00:00

abstract：:Altered expressions of the key enzymes in arachidonic acid (AA) metabolism, prostaglandin synthase 1 and 2 and cysteinyl leukotriene C(4) synthase, are of importance in understanding aspirin-induced asthma. We propose a mathematical model of AA metabolism and its interaction with non-steroidal anti-inflammatory drugs ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dobovišek A,Fajmut A,Brumen M

更新日期：2011-04-01 00:00:00

abstract：:Effective long-term treatment of Type 2 Diabetes Mellitus (T2DM) implies modification of the disease processes that cause this progressive disorder. This paper proposes a mechanism-based approach to disease progression modeling of T2DM that aims to provide the ability to describe and quantify the effects of treatment ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： de Winter W,DeJongh J,Post T,Ploeger B,Urquhart R,Moules I,Eckland D,Danhof M

更新日期：2006-06-01 00:00:00

abstract：:The population approach to estimating mixed effects model parameters of interest in pharmacokinetic (PK) studies has been demonstrated to be an effective method in quantifying relevant population drug properties. The information available for each individual is usually sparse. As such, care should be taken to ensure t...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dodds MG,Hooker AC,Vicini P

更新日期：2005-02-01 00:00:00

abstract：:The emerging discipline of mathematical pharmacology occupies the space between advanced pharmacometrics and systems biology. A characteristic feature of the approach is application of advance mathematical methods to study the behavior of biological systems as described by mathematical (most often differential) equati...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gibiansky L,Gibiansky E

更新日期：2018-02-01 00:00:00

abstract：:The majority of measures proposed to date for direct curve comparison in bioequivalence studies were investigated. These measures have often been called metrics, but in most cases this was incorrect in the mathematical sense. It was demonstrated, with a set of counter-examples, that the axioms of a metric are fulfille...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Jawień W

更新日期：2009-06-01 00:00:00

abstract：:Quantitative systems pharmacology (QSP) is a recent addition to the modeling and simulation toolbox for drug discovery and development and is based upon mathematical modeling of biophysical realistic biological processes in the disease area of interest. The combination of preclinical neurophysiology information with c...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Geerts H,Spiros A,Roberts P,Carr R

更新日期：2013-06-01 00:00:00

abstract：:Mixture models are applied in population pharmacometrics to characterize underlying population distributions that are not adequately approximated by a single normal or lognormal distribution. In addition to obtaining individualized maximum a posteriori Bayesian post hoc parameter estimates, the subpopulation to which ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaila N,Straka RJ,Brundage RC

更新日期：2007-04-01 00:00:00

abstract：:The purpose of this study was to evaluate whether mixed effects modeling (MEM) performs better than either noncompartmental or compartmental naïve pooled data (NPD) analysis for the interpretation of single sample per subject pharmacokinetic (PK) data. Using PK parameters determined during a toxicokinetic study in rat...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hing JP,Woolfrey SG,Greenslade D,Wright PM

更新日期：2001-04-01 00:00:00

abstract：:HER2-positive breast cancer (BC) is a rapidly growing and aggressive BC subtype that predominantly affects younger women. Despite improvements in patient outcomes with anti-HER2 therapy, primary and/or acquired resistance remain a major clinical challenge. Here, we sought to use a quantitative systems pharmacological ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Franco YL,Ramakrishnan V,Vaidya TR,Mody H,Perez L,Ait-Oudhia S

更新日期：2021-01-03 00:00:00

abstract：:The conventional convection-dispersion model is widely used to interrelate hepatic availability (F) and clearance (Cl) with the morphology and physiology of the liver and to predict effects such as changes in liver bloodflow on F and Cl. The extension of this model to include nonlinear kinetics and zonal heterogeneity...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Anissimov YG,Roberts MS

更新日期：2002-04-01 00:00:00