Abstract:
:In the present age of pharmaceutical research and development, focused delivery of decision making data is more imperative than ever before. Resulting from several years' success, failure and consequential learning, this article also proffers advice and guidance on which in vitro and in vivo experiments to perform to facilitate efficient and cost-effective pursuit of candidate drugs with acceptable human pharmacokinetic profiles. Predictive in silico models are important in directing design toward compounds with the highest probability of having suitable DMPK properties rather than in predicting human pharmacokinetics per se, and the value and utility of such approaches are reviewed with the intention of providing direction to DMPK scientists. Relating to absorption, distribution, elimination and effective half-life, strategies are described to provide direction in commonly encountered scenarios.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Grime KH,Barton P,McGinnity DFdoi
10.1021/mp300476zsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
1191-206issue
4eissn
1543-8384issn
1543-8392journal_volume
10pub_type
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