Abstract:
:The particle shape of the drug delivery systems had a strong impact on their in vitro and in vivo performance, but there was limited availability of techniques to produce the specific shaped drug carriers. In this article, the novel methotrexate (MTX) decorated MPEG-PLA nanobacillus (MPEG-PLA-MTX NB) was prepared by the self-assembly technique followed by the extrusion through SPG membrane with high N2 pressure for targeted drug delivery, in which Janus-like MTX was not only used as a specific anticancer drug but could also be served as a tumor-targeting ligand. The MPEG-PLA-MTX NBs demonstrated much higher in vitro and in vivo targeting efficiency compared to the MPEG-PLA-MTX nanospheres (MPEG-PLA-MTX NSs) and MPEG-PLA nanospheres (MPEG-PLA NSs). In addition, the MPEG-PLA-MTX NBs also displayed much more excellent in vitro and in vivo antitumor activity than the MPEG-PLA-MTX NSs and free MTX injection. To our knowledge, this work provided the first example of the integration of the shape design (which mediated an early phase tumor accumulation and a late-phase cell internalization) and Janus-faced function (which mediated an early phase active targeting effect and a late-phase anticancer effect) on the basis of nanoscaled drug delivery systems. The highly convergent and cooperative drug delivery strategy opens the door to more drug delivery systems with new shapes and functions for cancer therapy.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Cui F,Lin J,Li Y,Li Y,Wu H,Yu F,Jia M,Yang X,Wu S,Xie L,Ye S,Luo F,Hou Zdoi
10.1021/mp500464bsubject
Has Abstractpub_date
2015-04-06 00:00:00pages
1318-27issue
4eissn
1543-8384issn
1543-8392journal_volume
12pub_type
杂志文章abstract::Tablets which were binary mixtures of pioglitazone hydrochloride (PioHCl) with magnesium stearate (MgSt), croscarmellose sodium (CCS), microcrystalline cellulose, or lactose monohydrate were prepared. Two sets of experiments, using intact tablets, were performed. (i) Tablets containing PioHCl (90% w/w) and MgSt were e...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/acs.molpharmaceut.6b01052
更新日期:2017-04-03 00:00:00
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journal_title:Molecular pharmaceutics
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journal_title:Molecular pharmaceutics
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular pharmaceutics
pub_type: 杂志文章
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更新日期:2014-10-06 00:00:00
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更新日期:2013-03-04 00:00:00
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更新日期:2015-01-05 00:00:00
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更新日期:2014-06-02 00:00:00
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pub_type: 杂志文章
doi:10.1021/acs.molpharmaceut.0c00776
更新日期:2021-01-04 00:00:00
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pub_type: 杂志文章
doi:10.1021/acs.molpharmaceut.5b00375
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