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Shear stress and its effect on the interaction of myoblast cells with nanosized drug delivery vehicles.

Abstract：

:An important aspect to ensure progress in biomedicine is the fundamental understanding of the interaction of cells and tissue with (bio)materials. The consideration of shear stress in drug delivery and/or tissue engineering remains largely unexplored. To illustrate the fundamental relevance, we employ a microfluidic setup to evaluate the myoblast cell response to two prominent drug carrier systems, namely, liposomes and nanoparticles, in the presence of low shear stress. We show that positively charged carriers have an enhanced interaction with myoblast cells in the presence of shear stress. This effect can be translated into improved therapeutic response in terms of reduction in cell viability when delivering a cytotoxic compound or into a better translocation efficiency when using lipoplexes. Taken together, our fundamental findings open up new possibilities in tissue engineering and drug delivery by considering an additional parameter when delivering beneficial compounds.

journal_name

Mol Pharm

journal_title

Molecular pharmaceutics

authors

Hosta-Rigau L,Städler B

doi

10.1021/mp4001298

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2707-12

issue

7

eissn

1543-8384

issn

1543-8392

journal_volume

10

pub_type

杂志文章

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