Abstract:
:5-Fluorocytosine (FC), an antifungal drug and a cytosine derivative, has a complex solid-state landscape that challenges its development into a drug product. A total of eight new FC salts, both cytosinium and hemicytosinium, with four strong acids were prepared by controlling acid concentration in the crystallization medium. The pharmaceutically acceptable saccharin salt of FC exhibits superior phase stability and, hence, has the potential to address the instability problem of FC associated with hydration.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Perumalla SR,Pedireddi VR,Sun CCdoi
10.1021/mp400070asubject
Has Abstractpub_date
2013-06-03 00:00:00pages
2462-6issue
6eissn
1543-8384issn
1543-8392journal_volume
10pub_type
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