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Protruding domain of tomato bushy stunt virus coat protein is a hitherto unrecognized class of jellyroll conformation.

Abstract：

:The capsid protein of tomato bushy stunt virus (TBSV) has two antiparallel beta-sheet domains with the so-called jellyroll conformation. Contrary to previous analyses, we note that these domains are non-superimposable topologies. The TBSV shell (S) domain topology is common to many other proteins but the protruding (P) domain is a unique conformation so far found in no other protein. The TBSV capsid P domain did not arise from the S domain by a gene duplication event as previously assumed. It is proposed instead that the P domain was acquired from an as yet unidentified cellular protein. The four possible unique jellyroll topologies that might occur in proteins are discussed and illustrated.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Gibson TJ,Argos P

doi

10.1016/0022-2836(90)90298-Z

subject

Has Abstract

pub_date

1990-03-05 00:00:00

pages

7-9

issue

1

eissn

0022-2836

issn

1089-8638

pii

0022-2836(90)90298-Z

journal_volume

212

pub_type

杂志文章

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