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Telomeric Transcription and Telomere Rearrangements in Quiescent Cells.

Abstract：

:Despite the condensed nature of terminal sequences, the telomeres are transcribed into a group of noncoding RNAs, including the TElomeric Repeat-containing RNA (TERRA). Since the discovery of TERRA, its evolutionary conserved function has been confirmed, and its involvement in telomere length regulation, heterochromatin establishment, and telomere recombination has been demonstrated. We previously reported that TERRA is upregulated in quiescent fission yeast cells, although the global transcription is highly reduced. Elevated telomeric transcription was also detected when telomeres detach from the nuclear periphery. These intriguing observations unveil unexpected facets of telomeric transcription in arrested cells. In this review, we present the different aspects of TERRA transcription during quiescence and discuss their implications for telomere maintenance and cell fate.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Coulon S,Vaurs M

doi

10.1016/j.jmb.2020.01.034

subject

Has Abstract

pub_date

2020-07-10 00:00:00

pages

4220-4231

issue

15

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(20)30100-5

journal_volume

432

pub_type

杂志文章,评审

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