A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study.

abstract：INTRODUCTION:Before any new methodology can be introduced into the routine diagnostic setting it must be technically validated against the established standards. To this end, a ring study involving five international pathology laboratories was initiated to validate chromogenic in situ hybridisation (CISH) against fluor...

journal_title：Breast cancer research : BCR

authors： van de Vijver M,Bilous M,Hanna W,Hofmann M,Kristel P,Penault-Llorca F,Rüschoff J

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The presence of tumor cells in the axillary lymph nodes is the most important prognostic factor in early stage breast cancer. However, the optimal method for sentinel lymph node (SLN) examination is still sought and currently many different protocols are employed. To examine two approaches for tumor cell d...

journal_title：Breast cancer research : BCR

authors： Tveito S,Andersen K,Kåresen R,Fodstad Ø

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Dysregulated DNA repair and cell proliferation controls are essential driving forces in mammary tumorigenesis. BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The aims of t...

journal_title：Breast cancer research : BCR

authors： Droz-Rosario R,Lu H,Liu J,Liu NA,Ganesan S,Xia B,Haffty BG,Shen Z

更新日期：2017-10-18 00:00:00

abstract：:PIK3CA mutations represent one of the most common genetic aberrations in breast cancer. They have been reported to be present in over one-third of cases, with enrichment in the luminal and in human epidermal growth factor receptor 2-positive subtypes. Substantial preclinical data on the oncogenic properties of these m...

journal_title：Breast cancer research : BCR

authors： Zardavas D,Phillips WA,Loi S

更新日期：2014-01-23 00:00:00

abstract：INTRODUCTION:Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mamm...

journal_title：Breast cancer research : BCR

authors： Dunphy KA,Blackburn AC,Yan H,O'Connell LR,Jerry DJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Reliable predictive and prognostic markers for routine diagnostic purposes are needed for breast cancer patients treated with neoadjuvant chemotherapy. We evaluated protein biomarkers in a cohort of 116 participants of the GeparDuo study on anthracycline/taxane-based neoadjuvant chemotherapy for operable b...

journal_title：Breast cancer research : BCR

authors： Darb-Esfahani S,Loibl S,Müller BM,Roller M,Denkert C,Komor M,Schlüns K,Blohmer JU,Budczies J,Gerber B,Noske A,du Bois A,Weichert W,Jackisch C,Dietel M,Richter K,Kaufmann M,von Minckwitz G

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to describe breast tumor subtypes by common breast cancer risk factors and to determine correlates of subtypes using baseline data from two pooled prospective breast cancer studies within a large health maintenance organization. METHODS:Tumor data on 2544 invasive breast cancer c...

journal_title：Breast cancer research : BCR

authors： Kwan ML,Kushi LH,Weltzien E,Maring B,Kutner SE,Fulton RS,Lee MM,Ambrosone CB,Caan BJ

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Bisphosphonates are inhibitors of osteoclast-mediated tumor-stimulated osteolysis, and they have become standard therapy for the management of bone metastases from breast cancer. These drugs can also directly induce growth inhibition and apoptosis of osteotropic cancer cells, including estrogen receptor-po...

journal_title：Breast cancer research : BCR

authors： Journe F,Chaboteaux C,Magne N,Duvillier H,Laurent G,Body JJ

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:It has been suggested that individuals with reduced DNA repair capacities might have increased susceptibility to environmentally induced cancer. In this study, we evaluated if polymorphisms in DNA repair genes XRCC1 (Arg280His, Arg399Gln) and XPD (Lys751Gln) modify individual breast cancer risk, with empha...

journal_title：Breast cancer research : BCR

authors： Metsola K,Kataja V,Sillanpää P,Siivola P,Heikinheimo L,Eskelinen M,Kosma VM,Uusitupa M,Hirvonen A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH)D) in breast cancer development, but the results of epidemiological studies have been inconsistent. METHODS:We conducted a case-control study nested within two prospective cohorts, the New York University Women's H...

journal_title：Breast cancer research : BCR

authors： Scarmo S,Afanasyeva Y,Lenner P,Koenig KL,Horst RL,Clendenen TV,Arslan AA,Chen Y,Hallmans G,Lundin E,Rinaldi S,Toniolo P,Shore RE,Zeleniuch-Jacquotte A

更新日期：2013-02-26 00:00:00

abstract：INTRODUCTION:Rapamycin, an inhibitor of the serine/threonine kinase target of rapamycin, induces G1 arrest and/or apoptosis. Although rapamycin and its analogues are attractive candidates for cancer therapy, their sensitivities with respect to growth inhibition differ markedly among various cancer cells. Using human br...

journal_title：Breast cancer research : BCR

authors： Kasukabe T,Okabe-Kado J,Kato N,Sassa T,Honma Y

更新日期：2005-01-01 00:00:00

abstract：:Breast cancer risk is continuing to increase across all societies with rates in countries with traditionally lower risks catching up with the higher rates in the Western world. Although cure rates from breast cancer have continued to improve such that absolute numbers of breast cancer deaths have dropped in many count...

journal_title：Breast cancer research : BCR

authors： Evans DG,Howell A

更新日期：2015-07-09 00:00:00

abstract：INTRODUCTION:Bcl-2 and Bcl-xL confer resistance to apoptosis, thereby reducing the effectiveness of chemotherapy. We examined the relationship between the expression of Bcl-2 and Bcl-xL and chemosensitivity of breast cancer cells, with the aim of developing specific targeted therapy. METHODS:Four human breast cancer c...

journal_title：Breast cancer research : BCR

authors： Emi M,Kim R,Tanabe K,Uchida Y,Toge T

更新日期：2005-01-01 00:00:00

abstract：:Certain laminins of vascular basement membranes have been identified in human breast tumors and brain gliomas that share the same beta1 chain. These laminins are new carcinoma angiogenic markers and might represent potential targets for antiangiogenic therapy. ...

journal_title：Breast cancer research : BCR

authors： Holler E

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Metastasis is the main cause of breast cancer morbidity and mortality. Processes that allow for tumor cell migration and invasion are important therapeutic targets. Here we demonstrate that receptor-interacting protein kinase 2 (RIP2), a kinase known to be involved in inflammatory processes, also has novel...

journal_title：Breast cancer research : BCR

authors： Singel SM,Batten K,Cornelius C,Jia G,Fasciani G,Barron SL,Wright WE,Shay JW

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Women with breast cancer who have multiple affected relatives are more likely to have inherited genetic risk factors for the disease. All the currently known genetic risk factors for breast cancer account for less than half of the average familial risk. Furthermore, the genetic factor(s) underlying an increa...

journal_title：Breast cancer research : BCR

authors： Walker LC,Pearson JF,Wiggins GA,Giles GG,Hopper JL,Southey MC

更新日期：2017-03-16 00:00:00

abstract：INTRODUCTION:Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgic...

journal_title：Breast cancer research : BCR

authors： Ribas R,Ghazoui Z,Gao Q,Pancholi S,Rani A,Dunbier A,Dowsett M,Martin LA

更新日期：2014-10-31 00:00:00

abstract：:Osteolytic metastases due to breast cancer are serious events. The interactions between breast cancer cells with the microenvironment of bone have been thought to provide an ideal milieu for cancer cells. Recent data now indicate that migration of breast cancer cells into bone and their subsequent growth into metastas...

journal_title：Breast cancer research : BCR

authors： Hofbauer LC,Rachner T,Singh SK

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Texture patterns have been shown to improve breast cancer risk segregation in addition to area-based mammographic density. The additional value of texture pattern scores on top of volumetric mammographic density measures in a large screening cohort has never been studied. METHODS:Volumetric mammographic den...

journal_title：Breast cancer research : BCR

authors： Wanders JOP,van Gils CH,Karssemeijer N,Holland K,Kallenberg M,Peeters PHM,Nielsen M,Lillholm M

更新日期：2018-05-02 00:00:00

abstract：INTRODUCTION:Breast tumors are comprised of distinct cancer cell populations which differ in their tumorigenic and metastatic capacity. Characterization of cell surface markers enables investigators to distinguish between cancer stem cells and their counterparts. CD24 is a well-known cell surface marker for mammary epi...

journal_title：Breast cancer research : BCR

authors： Rostoker R,Abelson S,Genkin I,Ben-Shmuel S,Sachidanandam R,Scheinman EJ,Bitton-Worms K,Orr ZS,Caspi A,Tzukerman M,LeRoith D

更新日期：2015-06-04 00:00:00

abstract：:Immunohistochemistry is the most common method for companion diagnostic testing in breast cancer. The readings for estrogen receptor, progesterone receptor, and Her2 directly affect prescription of critical therapies. However, immunohistochemistry is highly sensitive to innumerable pre-analytic variables that result i...

journal_title：Breast cancer research : BCR

authors： Siddiqui S,Rimm DL

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood. METHODS:From 32,295 female BRCA1/2 mutation carriers, w...

journal_title：Breast cancer research : BCR

authors： Rebbeck TR,Friebel TM,Mitra N,Wan F,Chen S,Andrulis IL,Apostolou P,Arnold N,Arun BK,Barrowdale D,Benitez J,Berger R,Berthet P,Borg A,Buys SS,Caldes T,Carter J,Chiquette J,Claes KB,Couch FJ,Cybulski C,Daly MB,d

更新日期：2016-11-11 00:00:00

abstract：:Recent studies indicate that constitutive signaling through the phosphatidylinositol 3'-kinase (PI3K) pathway is a cause of treatment resistance in breast cancer patients. This implies that patients with tumors that exhibit aberrant PI3K signaling may benefit from targeted pathway inhibitors. The first agents to make ...

journal_title：Breast cancer research : BCR

authors： Crowder RJ,Ellis MJ

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondria...

journal_title：Breast cancer research : BCR

authors： Blein S,Bardel C,Danjean V,McGuffog L,Healey S,Barrowdale D,Lee A,Dennis J,Kuchenbaecker KB,Soucy P,Terry MB,Chung WK,Goldgar DE,Buys SS,Breast Cancer Family Registry.,Janavicius R,Tihomirova L,Tung N,Dorfling CM,va

更新日期：2015-04-25 00:00:00

abstract：INTRODUCTION:Current approaches to inhibit oestrogen receptor-alpha (ERα) are focused on targeting its hormone-binding pocket and have limitations. Thus, we propose that inhibitors that bind to a coactivator-binding pocket on ERα, called activation function 2 (AF2), might overcome some of these limitations. METHODS:In...

journal_title：Breast cancer research : BCR

authors： Singh K,Munuganti RS,Leblanc E,Lin YL,Leung E,Lallous N,Butler M,Cherkasov A,Rennie PS

更新日期：2015-02-25 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a tumor suppressor, the function of which is compromised in many types of human cancer, including breast cancer. The tumor suppressive effects of TGF-beta are caused by potent inhibition of cell proliferation due to cell cycle arrest in the G1 phase. Such antiproliferative...

journal_title：Breast cancer research : BCR

authors： Kretzschmar M

更新日期：2000-01-01 00:00:00

abstract：:Two articles previously published in Breast Cancer Research illustrate the high rates of breast cancer in Marin County, a wealthy, urban county immediately northwest of the city of San Francisco. I herein comment on these articles, and on the political/psychological/scientific dilemma presented by regions with high ca...

journal_title：Breast cancer research : BCR

authors： Whittemore AS

更新日期：2003-01-01 00:00:00

abstract：:c-Met is a receptor tyrosine kinase that upon binding of its ligand, hepatocyte growth factor (HGF), activates downstream pathways with diverse cellular functions that are important in organ development and cancer progression. Anomalous c-Met signalling has been described in a variety of cancer types, and the receptor...

journal_title：Breast cancer research : BCR

authors： Ho-Yen CM,Jones JL,Kermorgant S

更新日期：2015-04-08 00:00:00

abstract：BACKGROUND:Bone is one of the most frequent metastatic sites of advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal bone remodeling, the balance between bone resorption and osteoblast-mediated bone formation is essential f...

journal_title：Breast cancer research : BCR

authors： Liu X,Cao M,Palomares M,Wu X,Li A,Yan W,Fong MY,Chan WC,Wang SE

更新日期：2018-10-22 00:00:00

abstract：:In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be full...

journal_title：Breast cancer research : BCR

authors： Martelotto LG,Ng CK,Piscuoglio S,Weigelt B,Reis-Filho JS

更新日期：2014-05-20 00:00:00