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Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway.

Abstract：

:Recent studies indicate that constitutive signaling through the phosphatidylinositol 3'-kinase (PI3K) pathway is a cause of treatment resistance in breast cancer patients. This implies that patients with tumors that exhibit aberrant PI3K signaling may benefit from targeted pathway inhibitors. The first agents to make it to the clinic are the rapamycin analogs. These compounds inhibit the downstream PI3K effector mTOR (mammalian target of rapamycin). A study presented in this issue of Breast Cancer Research suggests that recently developed inhibitors of phosphoinositide-dependent protein kinase 1, a more proximal target of the PI3K pathway, may provide an alternative route to effective PI3K pathway inhibition for breast cancer treatment.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Crowder RJ,Ellis MJ

doi

10.1186/bcr1307

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

212-4

issue

5

eissn

1465-5411

issn

1465-542X

pii

bcr1307

journal_volume

7

pub_type

评论,杂志文章

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