Abstract：
:Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically. Although they have never completely fallen out of favor, their importance has waned due to the emergence of other broad-spectrum antibiotics with fewer side effects. Today, with the dramatically increasing rate of infections caused by multidrug-resistant bacteria, focus has returned to aminoglycoside antibiotics as one of the few remaining treatment options, particularly for Gram-negative pathogens. Although the mechanisms of resistance are reasonably well understood, our knowledge about the mode of action of aminoglycosides is still far from comprehensive. In the face of emerging bacterial infections that are virtually untreatable, it is time to have a fresh look at this old class to reinvigorate the struggle against multidrug-resistant pathogens.
journal_name
ACS Chem Bioljournal_title
ACS chemical biologyauthors
Becker B,Cooper MAdoi
10.1021/cb3005116subject
Has Abstractpub_date
2013-01-18 00:00:00pages
105-15issue
1eissn
1554-8929issn
1554-8937journal_volume
8pub_type
杂志文章,评审abstract：:Glycosaminoglycans (GAGs), such as heparin or heparan sulfate, are required for the in vivo function of chemokines. Chemokines play a crucial role in the recruitment of leukocyte subsets to sites of inflammation and lymphocytes trafficking. GAG-chemokine interactions mediate cell migration and determine which leukocyt...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb700159m
更新日期：2007-11-20 00:00:00
abstract：:The LpxC enzyme in the lipid A biosynthetic pathway is one of the most promising and clinically unexploited antibiotic targets for treatment of multidrug-resistant Gram-negative infections. Progress in medicinal chemistry has led to the discovery of potent LpxC inhibitors with a variety of chemical scaffolds and disti...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb400067g
更新日期：2014-01-17 00:00:00
abstract：:The goal of incorporating renewable carbon into the fuel and chemical enterprise will most likely be successful when combined systems of biocatalysts and chemical catalysts are exploited. Significant efforts in the biocatalytic release of sugars from biomass are being pursued for subsequent use in fermentation. Two re...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb7001522
更新日期：2007-08-17 00:00:00
abstract：:Small molecule kinase inhibitors that stabilize distinct ATP binding site conformations can differentially modulate the global conformation of Src-family kinases (SFKs). However, it is unclear which specific ATP binding site contacts are responsible for modulating the global conformation of SFKs and whether these inhi...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.0c00429
更新日期：2020-07-17 00:00:00
abstract：:An attractive approach for developing therapeutic peptides is to enhance binding to their targets by stabilizing their α-helical conformation, for example, stabilized BimBH3 peptides (BimSAHB) designed to induce apoptosis. Unexpectedly, we found that such modified peptides have reduced affinity for their targets, the ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb3005403
更新日期：2013-02-15 00:00:00
abstract：:Base deamination is a common type of DNA damage that occurs in all organisms. DNA repair mechanisms are critical to maintain genome integrity, in which the base excision repair pathway plays an essential role. In the BER pathway, the uracil DNA glycosylase superfamily is responsible for removing the deaminated bases f...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.6b00164
更新日期：2016-06-17 00:00:00
abstract：:Mutations in the NPHP1 gene, coding for human nephrocystin-1 (NPHP1), cause the autosomal recessive disease nephronophthisis, the most common cause of end-stage renal disease in children and adolescents. The function and structure of NPHP1 are still poorly characterized. NPHP1 presents a modular structure well in keep...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.9b00582
更新日期：2019-08-16 00:00:00
abstract：:The neurotoxin saxitoxin and related paralytic shellfish toxins are produced by multiple species of cyanobacteria and dinoflagellates. This study investigates the two saxitoxin-producing strains of Scytonema crispum, CAWBG524 and CAWBG72, isolated in New Zealand. Each strain was previously reported to have a distinct ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.8b00608
更新日期：2018-11-16 00:00:00
abstract：:Dysregulated activity of the protease matriptase is a key contributor to aggressive tumor growth, cancer metastasis, and osteoarthritis. Methods for the detection and quantification of matriptase activity and inhibition would be useful tools. To address this need, we developed a matriptase-sensitive protein biosensor ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.7b00715
更新日期：2018-01-19 00:00:00
abstract：:Access to well-defined ubiquitin conjugates has been key to elucidating the biochemical functions of proteins in the ubiquitin signaling network. Yet, we have a poor understanding of how deubiquitinases and ubiquitin-binding proteins respond to ubiquitin modifications when anchored to a protein other than ubiquitin or...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.8b00759
更新日期：2018-09-21 00:00:00
abstract：:This Letter reports a family of novel antimicrobial compounds obtained by combining peptide library screening with structure-based design. Library screening led to the identification of a human LL-37 peptide resistant to chymotrypsin. This d-amino-acid-containing peptide template was active against Escherichia coli bu...
journal_title：ACS chemical biology
pub_type： 信件
doi：10.1021/cb500475y
更新日期：2014-09-19 00:00:00
abstract：:Clostridium difficile, a leading cause of hospital-acquired infection, possesses a dense surface layer (S-layer) that mediates host-pathogen interactions. The key structural components of the S-layer result from proteolytic cleavage of a precursor protein, SlpA, into high- and low-molecular-weight components. Here we ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb9002859
更新日期：2010-03-19 00:00:00
abstract：:Bioorthogonal ligation methods that allow the selective conjugation of fluorophores or biotin to proteins and small molecule probes that contain inert chemical handles are an important component of many chemical proteomic strategies. Here, we present a new catch-and-release enrichment strategy that utilizes a hexylchl...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb300623a
更新日期：2013-04-19 00:00:00
abstract：:Desferrioxamine B (DFOB) was discovered in the late 1950s as a hydroxamic acid metabolite of the soil bacterium Streptomyces pilosus. The exquisite affinity of DFOB for Fe(III) identified its potential for removing excess iron from patients with transfusion-dependent hemoglobin disorders. Many studies have used semisy...
journal_title：ACS chemical biology
pub_type： 杂志文章,评审
doi：10.1021/acschembio.7b00851
更新日期：2018-01-19 00:00:00
abstract：:miRNAs are small non-coding RNAs that regulate about 60% of mammalian genes by modulating their transcript levels. Network scale studies of miRNA-mediated regulatory circuits demonstrate the central importance of this class of small RNA in the maintenance of biological robustness. More recently, several reports have d...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb300650y
更新日期：2013-05-17 00:00:00
abstract：:A biophysical understanding of the mechanistic, chemical, and physical origins underlying antibiotic action and resistance is vital to the discovery of novel therapeutics and the development of strategies to combat the growing emergence of antibiotic resistance. The site-specific introduction of stable-isotope labels ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.9b01054
更新日期：2020-05-15 00:00:00
abstract：:Epigenetic regulation is directed, in part, by the correlated placement of histone post-translational modifications, but the mechanisms controlling correlated modifications are incompletely understood. Correlations arise from crosstalk among modifications and are frequently attributed to protein-protein interactions t...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb5004527
更新日期：2015-01-16 00:00:00
abstract：:Pathogenic Yersinia spp. secrete the effector YopJ (YopP) into host cells to counteract cytokine production and to induce programmed cell death (apoptosis). YopJ achieves these aims by inactivating mitogen-activated protein kinase (MAPK) and nuclear factor kappaB signaling pathways. YopJ was shown to bind to members o...
journal_title：ACS chemical biology
pub_type： 杂志文章,评审
doi：10.1021/cb600261k
更新日期：2006-07-21 00:00:00
abstract：:A major risk for patients having estrogen receptor α (ERα)-positive breast cancer is the recurrence of drug-resistant metastases after initial successful treatment with endocrine therapies. Recent studies have implicated a number of activating mutations in the ligand-binding domain of ERα that stabilize the agonist co...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.8b00877
更新日期：2018-12-21 00:00:00
abstract：:Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile targets adducted under pathophysiological conditions. Incorporation of ω-alkynyl linoleic acid into the phospholipids of macrophages prior to activation by Kdo2-lip...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.7b00480
更新日期：2017-08-18 00:00:00
abstract：:Developing computational tools for a chassis-centered biosynthetic pathway design is very important for a productive heterologous biosynthesis system by considering enormous foreign biosynthetic reactions. For many cases, a pathway to produce a target molecule consists of both native and heterologous reactions when ut...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.7b00605
更新日期：2017-11-17 00:00:00
abstract：:The limited clinical success of therapeutics targeting cellular signaling processes is due to multiple factors, including off-target effects and complex feedback regulation encoded within the signaling network. To understand these effects, chemical proteomics and chemical genetics tools have been developed to map the ...
journal_title：ACS chemical biology
pub_type： 杂志文章,评审
doi：10.1021/cb1002834
更新日期：2011-01-21 00:00:00
abstract：:The abundant observation of chemical fragment information for molecular complexities is a major advantage of biological NMR analysis. Thus, the development of a novel technique for NMR signal assignment and metabolite identification may offer new possibilities for exploring molecular complexities. We propose a new sig...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.5b00894
更新日期：2016-04-15 00:00:00
abstract：:Post-translational modifications of histones alter chromatin structure and play key roles in gene expression and specification of cell states. Small molecules that target chromatin-modifying enzymes selectively are useful as probes and have promise as therapeutics, although very few are currently available. G9a (also ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb300139y
更新日期：2012-07-20 00:00:00
abstract：:Ascarosides are small-molecule signals that play a central role in C. elegans biology, including dauer formation, aging, and social behaviors, but many aspects of their biosynthesis remain unknown. Using automated 2D NMR-based comparative metabolomics, we identified ascaroside ethanolamides as shunt metabolites in C. ...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb3004644
更新日期：2013-02-15 00:00:00
abstract：:Protein phosphatases are critical regulators of cellular signaling in both eukaryotes and prokaryotes. The majority of protein phosphatases dephosphorylate phosphoserine/phosphothreonine or phosphotyrosine residues. Recently, however, YwlE, a member of the low-molecular weight protein tyrosine phosphatase (LMW-PTP) fa...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb4001469
更新日期：2013-09-20 00:00:00
abstract：:A strategy has been established for the synthesis of a family of bifunctional HIV-1 inhibitor covalent conjugates with the potential to bind simultaneously to both the gp120 and gp41 subunits of the HIV-1 envelope glycoprotein trimeric complex (Env). One component of the conjugates is derived from BNM-III-170, a small...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.0c00888
更新日期：2021-01-15 00:00:00
abstract：:In urodele amphibians, an early step in limb regeneration is skeletal muscle fiber dedifferentiation into a cellulate that proliferates to contribute new limb tissue. However, mammalian muscle cannot dedifferentiate after injury. We have developed a novel, small-molecule-based method to induce dedifferentiation in mam...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/cb200532v
更新日期：2012-04-20 00:00:00
abstract：:Bacterial resistance to conventional antibiotics is of major concern. Antimicrobial peptides (AMPs) are considered excellent alternatives. Among them, D-cateslytin (D-Ctl, derivative of a host defense peptide) has shown high efficiency against a broad spectrum of bacteria. The first target of AMPs is the outer membran...
journal_title：ACS chemical biology
pub_type： 杂志文章
doi：10.1021/acschembio.0c00622
更新日期：2020-10-16 00:00:00
abstract：:We evaluated the abilities of an antisense oligonucleotide (ASO), a small interfering RNA (siRNA), and a single-stranded siRNA (ss-siRNA) to inhibit expression from the PTEN gene in mice when formulated identically with lipid nanoparticles (LNPs). Significantly greater reductions in levels of PTEN mRNA were observed f...
journal_title：ACS chemical biology
pub_type： 信件
doi：10.1021/cb4001316
更新日期：2013-07-19 00:00:00
