Magnetic resonance transverse relaxation time T2 of knee cartilage in osteoarthritis at 3-T: a cross-sectional multicentre, multivendor reproducibility study.

Abstract:

OBJECTIVE:The transverse relaxation time (T2) in MR imaging has been identified as a potential biomarker of hyaline cartilage pathology. This study investigates whether MR assessments of T2 are comparable between 3-T scanners from three different vendors. DESIGN:Twelve subjects with symptoms of knee osteoarthritis and one or more risk factors had their knee scanned on each of the three vendors' scanners located in three sites in the U.K. MR data acquisition was based on the United States National Institutes of Health Osteoarthritis Initiative protocol. Measures of cartilage T2 and R2 (inverse of T2) were computed for precision error assessment. Intrascanner reproducibility was also assessed with a phantom (all three scanners) and a cohort of 5 subjects (one scanner only). RESULTS:Whole-organ magnetic resonance (WORM) semiquantitative cartilage scores ranged from minimal to advanced degradation. Intrascanner R2 root-mean-square coefficients of variation (RMSCOV) were low, within the range 2.6 to 6.3% for femoral and tibial regions. For one scanner pair, mean T2 differences ranged from -1.2 to 2.8 ms, with no significant difference observed for the medial tibia and patella regions (p < 0.05). T2 values from the third scanner were systematically lower, producing interscanner mean T2 differences within the range 5.4 to 10.0 ms. CONCLUSION:Significant interscanner cartilage T2 differences were found and should be accounted for before data from scanners of different vendors are compared.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Balamoody S,Williams TG,Wolstenholme C,Waterton JC,Bowes M,Hodgson R,Zhao S,Scott M,Taylor CJ,Hutchinson CE

doi

10.1007/s00256-012-1511-5

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

511-20

issue

4

eissn

0364-2348

issn

1432-2161

journal_volume

42

pub_type

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