当前位置： SCI文献检索 > SKELETAL RADIOLOGY期刊下所有文献 > Iodine-125 labeled phenylphosphonic acid: a new radiopharmaceutical for long-term investigations of the skeleton.

Iodine-125 labeled phenylphosphonic acid: a new radiopharmaceutical for long-term investigations of the skeleton.

Abstract：

:A skeletal seeking radiopharmaceutical labeled with a long-lived radionuclide was developed to evaluate regional bone formation and its subsequent resorption. The agent is [phosphonate (phenylmethylene hydroxy) bis] - I-125 or I-125 phi PA. Tissue distribution studies in mice (N = 16) showed approximately 40% of the administered dose to be retained by the skeleton up to 336 hours post IV injection. The percentage of the dose accumulated by the thyroid gland remained at less than 0.5%, indicating minimal deiodination of the I-125 phi PA. Whole body retention studies in the same species revealed a triexponential release pattern with the longest component comprising 33% of the dose with a biologic half-life of 962 days. A fractured rat tibia model was studied with I-125 phi PA and Tc-99m MDP. Chronic loss of the I125 phi PA relative to normal tibia was quantitated: five days (62.8%); 30 days (47.4%). Concomitant increased uptake of the Tc-99m MDP was observed at the fracture site relative to normal: five days (186%); 30 days (1,041%). The above data suggest that I-125 phi PA can be utilized to measure acute bone formation and chronic resorption.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Castronovo FP Jr,Strauss HW,McKusick KA,Potsaid MS

doi

10.1007/BF00361978

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

233-7

issue

4

eissn

0364-2348

issn

1432-2161

journal_volume

7

pub_type

杂志文章

相关文献

SKELETAL RADIOLOGY文献大全
  • The skeletal manifestations of chronic myelogenous leukemia.

    abstract：:Skeletal lesions were radiographically apparent in 6 of 36 (16%) patients with chronic myelogenous leukemia. The spectrum of radiographic changes including diffuse osteoporosis, focal osteolytic and osteoblastic lesions, chloroma, and arthritis, and their clinical behavior is discussed. ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00347255

    authors： Schabel SI,Tyminski L,Holland RD,Rittenberg GM

    更新日期：1980-01-01 00:00:00

  • Ultrasound of the distal biceps brachii tendon using four approaches: reproducibility and reader preference.

    abstract：OBJECTIVES:To determine which sonographic appearance of the distal biceps brachii tendon (DBBT) is preferred by readers, and if images obtained by two different operators are reproducible. METHODS:We performed an IRB-approved prospective sonographic evaluation of the DBBT in 50 healthy elbows using four different appr...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-020-03637-z

    authors： Miller TT,Konin GP,Nguyen JT,Kothary S,Nwawka OK,Endo Y,Saboeiro GR

    更新日期：2020-10-08 00:00:00

  • Posterior atlantoaxial dislocation complicating odontoid fracture without neurologic deficit: a case report and review of the literature.

    abstract：:Traumatic posterior atlantoaxial dislocation associated with odontoid fracture is extremely rare, with only eight cases reported thus far in the English literature. This report concerns a 47-year-old female who presented with considerable pain and stiffness in the neck without a neurologic deficit after injury due to ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00256-013-1809-y

    authors： Meng H,Gao Y,Li M,Luo Z,Du J

    更新日期：2014-07-01 00:00:00

  • Use of routine computed tomography scans for detecting osteoporosis in thoracolumbar vertebral bodies.

    abstract：OBJECTIVE:This study observed the distribution of CT attenuation values for T10-L3 vertebral bodies and derived the Hounsfield unit (HU) thresholds using the quantitative computed tomography (QCT) as a reference to predict osteoporosis and normal bone density. METHODS:We included 482 subjects who were scheduled to und...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-020-03573-y

    authors： Wang P,She W,Mao Z,Zhou X,Li Y,Niu J,Jiang M,Huang G

    更新日期：2021-02-01 00:00:00

  • The role of MRI in image-guided needle biopsy of focal bone and soft tissue neoplasms.

    abstract：:Magnetic resonance imaging (MRI) plays a critical role in the management pathway of both soft tissue and bone neoplasms, from diagnosis through to post-treatment follow-up. There are a wide range of surgical, oncological, and combined treatment regimes but these rely on accurate histopathological diagnosis. This artic...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00256-013-1630-7

    authors： Khoo MM,Saifuddin A

    更新日期：2013-07-01 00:00:00

  • Subchondral insufficiency fracture of the femoral head after liver transplantation.

    abstract：:A 53-year-old woman developed a subchondral insufficiency fracture of the right femoral head after undergoing a liver transplantation. Radiographs obtained at her first visit demonstrated a slight subchondral collapse in the superolateral portion of the femoral head. Magnetic resonance imaging (MRI) disclosed an irreg...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-009-0706-x

    authors： Iwasaki K,Yamamoto T,Nakashima Y,Mawatari T,Motomura G,Ikemura S,Iwamoto Y

    更新日期：2009-09-01 00:00:00

  • MRI in inflammatory myopathies.

    abstract：:Inflammatory myopathies encompass a group of acquired muscle disorders caused by infectious agents (bacteria, viruses, fungi and parasitic agents) or autoimmune processes (polymyositis, dermatomyositis and other types). In suspected infection sonography, CT and MRI are all able to show edema and fluid collections in s...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s002560000238

    authors： Garcia J

    更新日期：2000-08-01 00:00:00

  • Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

    abstract：:Chordomas are rare malignant bone tumours considered to arise from notochordal remnants that persist in the axial skeleton. Although their morphology can resemble that of a carcinoma, chondrosarcoma or malignant melanoma, the axial location and their well-defined immunophenotype, including expression of cytokeratins (...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-006-0167-4

    authors： O'donnell P,Tirabosco R,Vujovic S,Bartlett W,Briggs TW,Henderson S,Boshoff C,Flanagan AM

    更新日期：2007-01-01 00:00:00

  • C-arm flat-panel CT arthrography of the wrist and elbow: first experiences in human cadavers.

    abstract：OBJECTIVE:To determine the optimal intra-articular iodine concentration for C-arm flat-panel computed tomography (FPCT) arthrography using advanced joint phantoms and to evaluate its application in human cadaveric wrists and elbows. Multi-detector (MD) CT served as the standard of reference. MATERIALS AND METHODS:Join...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-012-1501-7

    authors： Guggenberger R,Morsbach F,Alkadhi H,Vich M,Pfammatter T,Hodler J,Andreisek G

    更新日期：2013-03-01 00:00:00

  • Cross-sectional imaging of adult crystal and inflammatory arthropathies.

    abstract：:This article highlights the key aspects and current perspectives of the role of cross-sectional imaging in adult crystal and inflammatory arthropathies in adults, briefly discussing CT, and particularly focusing on MRI and US imaging as it supplements the conventional radiography. The role of conventional and advanced...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00256-016-2402-y

    authors： Soldatos T,Pezeshk P,Ezzati F,Karp DR,Taurog JD,Chhabra A

    更新日期：2016-09-01 00:00:00

  • Subacute osteoporotic compression fracture: misleading magnetic resonance appearance.

    abstract：:Three patients with benign subacute osteoporotic vertebral compression fractures are presented. T1 weighted magnetic resonance (MR) images (SE 500/30) showed decreased vertebral signal. Because the results of the MR examination were thought to indicate malignant disease, extensive medical workups, including one biopsy...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00365140

    authors： Frager D,Elkin C,Swerdlow M,Bloch S

    更新日期：1988-01-01 00:00:00

  • Vascular calcifications on the preoperative radiograph: harbinger of tourniquet failure in patients undergoing total knee arthroplasty?

    abstract：OBJECTIVE:Vascular calcifications on the preoperative radiograph of patients scheduled for total knee arthroplasty (TKA) often give rise to concern, as their clinical relevance remains uncertain. The aim of this study was to investigate whether these vascular calcifications-especially medial artery calcifications (MACs...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-017-2681-y

    authors： Woelfle-Roos JV,Dautel L,Mayer B,Bieger R,Woelfle KD,Reichel H

    更新日期：2017-09-01 00:00:00

  • Non-neoplastic causes of high signal intensity at T2-weighted MR imaging after treatment for musculoskeletal neoplasm.

    abstract：OBJECTIVE:The objective of this study was to describe a variety of non-neoplastic causes of high-signal-intensity areas seen on T2-weighted magnetic resonance (MR) images obtained after treatment for malignant musculoskeletal neoplasm. DESIGN:MR examinations obtained after treatment for malignant musculoskeletal neopl...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00228920

    authors： Panicek DM,Schwartz LH,Heelan RT,Caravelli JF

    更新日期：1995-04-01 00:00:00

  • Distal radioulnar joint subluxation and dislocation diagnosed by standard roentgenography.

    abstract：:The use of standard lateral roentgenography for diagnosing distal radioulnar joint (DRUJ) subluxation and dislocation was investigated. Using a wrist support, bilateral standard lateral roentgenograms of the wrist were obtained in 42 patients with normal wrists and in 56 patients with a unilateral wrist injury. In nor...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00198067

    authors： Nakamura R,Horii E,Imaeda T,Tsunoda K,Nakao E

    更新日期：1995-02-01 00:00:00

  • Deep learning method for segmentation of rotator cuff muscles on MR images.

    abstract：OBJECTIVE:To develop and validate a deep convolutional neural network (CNN) method capable of (1) selecting a specific shoulder sagittal MR image (Y-view) and (2) automatically segmenting rotator cuff (RC) muscles on a Y-view. We hypothesized a CNN approach can accurately perform both tasks compared with manual referen...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-020-03599-2

    authors： Medina G,Buckless CG,Thomasson E,Oh LS,Torriani M

    更新日期：2020-09-16 00:00:00

  • Stener-like lesion of the lateral collateral ligament of the first metatarsophalangeal joint.

    abstract：:Displaced ulnar collateral ligament injuries of the metacarpophalangeal joint of the thumb, also known as Stener lesions, are a well-recognized clinical entity, requiring surgical intervention because of the trapped location of the torn lateral collateral ligament superficial to the adductor aponeurosis of the thumb. ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-017-2790-7

    authors： Braspenningx S,Rezaie W,Simons P

    更新日期：2018-03-01 00:00:00

  • Magnetic resonance imaging in the evaluation of ligament injuries.

    abstract：:Magnetic resonance imaging has had a dramatic effect on the means by which we diagnose ligament injuries. Tears resulting from either acute trauma or overuse can be detected noninvasively, directing appropriate therapy be it conservative or surgical. For the elite athlete, earlier diagnosis leads to earlier interventi...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s002560050476

    authors： Farooki S,Seeger LL

    更新日期：1999-02-01 00:00:00

  • Soft tissue Langerhans cell histiocytosis with secondary bone involvement in extremities: evolution of lesions in two patients.

    abstract：:Langerhans cell histiocytosis (LCH) is an uncommon disorder of unknown etiology with a wide spectrum of biological behavior. The most common sites of involvement are bone, skin, and lung. While osseous LCH can result in secondary soft tissue involvement, primary soft tissue LCH in extremities with secondary bone invol...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00256-013-1611-x

    authors： Amini B,Kumar R,Wang WL

    更新日期：2013-09-01 00:00:00

  • Skeletal manifestations of lysinuric protein intolerance. A follow-up study of 29 patients.

    abstract：:Lysinuric protein intolerance (LPI) is an autosomal recessive disease caused by defective transport of the cationic amino acids lysine, arginine, and ornithine at the cell membrane. About 80 patients with LPI have been described worldwide, almost half of them in Finland. The symptoms appear in early childhood as a fai...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00191519

    authors： Svedström E,Parto K,Marttinen M,Virtama P,Simell O

    更新日期：1993-01-01 00:00:00

  • Eosinophilic granuloma: MRI manifestations.

    abstract：:The appearance on magnetic resonance imaging (MRI) of 16 cases of pathologically proven eosinophilic granuloma were reviewed retrospectively and correlated with the radiographic appearance of the lesion. The most common MR appearance (ten cases) was a focal lesion, surrounded by an extensive, ill-defined bone marrow a...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00206144

    authors： Beltran J,Aparisi F,Bonmati LM,Rosenberg ZS,Present D,Steiner GC

    更新日期：1993-01-01 00:00:00

  • MR imaging based strategies in limb salvage surgery for osteosarcoma of the distal femur.

    abstract：OBJECTIVE:To analyse to what extent MR imaging based decisions were correct in determining the surgical procedure in patients with osteosarcoma of the distal femur. DESIGN:We compared the findings on MR imaging that determined the surgical strategy with the actual surgical findings or histopathological specimen. We as...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s002560050302

    authors： van Trommel MF,Kroon HM,Bloem JL,Hogendoorn PC,Taminiau AH

    更新日期：1997-11-01 00:00:00

  • Symmetrical ilial pseudofractures: a complication of chronic renal failure. A case report with a review of the literature.

    abstract：:A patient with chronic renal failure and progressive symmetrical ilial pseudofractures (Looser zones, Milkman's syndrome) is presented. The literature is reviewed in light of the findings in this patient, and possible mechanisms of pseudofracture formation are discussed. ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF02219626

    authors： Griffin CN Jr

    更新日期：1982-01-01 00:00:00

  • The deltoid, a forgotten muscle of the shoulder.

    abstract：:The deltoid is a fascinating muscle with a significant role in shoulder function. It is comprised of three distinct portions (anterior or clavicular, middle or acromial, and posterior or spinal) and acts mainly as an abductor of the shoulder and stabilizer of the humeral head. Deltoid tears are not infrequently associ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00256-013-1667-7

    authors： Moser T,Lecours J,Michaud J,Bureau NJ,Guillin R,Cardinal É

    更新日期：2013-10-01 00:00:00

  • Kashin-Beck disease in children: radiographic findings in the wrist.

    abstract：OBJECTIVE:To characterize the features and prevalence of radiographic abnormalities of the wrist in children with Kashin-Beck disease (KBD) and to determine whether the presence of radiographic abnormalities in the wrist correlates with the severity of KBD. DESIGN AND PATIENTS:Two hundred and eight posteroanterior rad...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-002-0475-2

    authors： Yu W,Wang Y,Jiang Y,Cheng X,Wang L,Genant K

    更新日期：2002-04-01 00:00:00

  • Painful swelling in the proximal third of the arm.

    abstract：: ...

    journal_title：Skeletal radiology

    pub_type：

    doi：10.1007/s00256-018-2997-2

    authors： Aparisi Gómez MP,Aparisi F,Bazzocchi A

    更新日期：2018-12-01 00:00:00

  • Bilateral avulsion fractures of the anterior superior iliac spines in sprinters.

    abstract：:Three cases of bilateral pelvic avulsion fractures in adolescent sprinters are reviewed. An-acute avulsion fracture of the anterior superior iliac spine (ASIS) occurred during active running in three teenaged sprinters. Radiography confirmed a healed fracture of the contralateral ASIS. The clinical features and radiol...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/BF00349098

    authors： Khoury MB,Kirks DR,Martinez S,Apple J

    更新日期：1985-01-01 00:00:00

  • MRI guided needle localization in a patient with recurrence pleomorphic sarcoma and post-operative scarring.

    abstract：:MRI-guided wire localization is commonly used for surgical localization of breast lesions. Here we introduce an alternative use of this technique to help with surgical resection of a recurrent pleomorphic sarcoma embedded in extensive post-treatment scar tissue. We describe a case of recurrent pleomorphic soft tissue ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-017-2614-9

    authors： Chang CD,Wei J,Goldsmith JD,Gebhardt MC,Wu JS

    更新日期：2017-07-01 00:00:00

  • Image intensifier distortion influences a surgeon's ability to aim guidewires during orthopaedic procedures.

    abstract：OBJECTIVE:Accurate insertion of a guidewire under image intensifier guidance is a fundamental skill required by orthopaedic surgeons. This study investigated how image intensifier distortion, which is composed of pin-cushion and sigmoidal components, changed the apparent trajectory of a guidewire, and the resulting dev...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-019-03171-7

    authors： Ward TR,Schwarz B,Le BTN,Smith GCS,Molnar RB,Smith PN

    更新日期：2019-09-01 00:00:00

  • Evaluation of anterior talofibular ligament injury with stress radiography, ultrasonography and MR imaging.

    abstract：OBJECTIVE:The purpose of this study was to clarify the efficacy of stress radiography (stress X-P), ultrasonography (US), and magnetic resonance (MR) imaging in the detection of the anterior talofibular ligament (ATFL) injury. METHODS:Thirty-four patients with ankle sprain were involved. In all patients, Stress X-P, U...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-009-0767-x

    authors： Oae K,Takao M,Uchio Y,Ochi M

    更新日期：2010-01-01 00:00:00

  • Potential use of (18)F-FDG-PET/CT to visualize hypermetabolism associated with muscle pain in patients with adult spinal deformity: a case report.

    abstract：:Patients with adult spinal deformity (ASD) are surgically treated for pain relief; however, visualization of the exact origin of the pain with imaging modalities is still challenging. We report the first case of a 60-year-old female patient who presented with painful degenerative kyphoscoliosis and was evaluated with ...

    journal_title：Skeletal radiology

    pub_type： 杂志文章

    doi：10.1007/s00256-016-2464-x

    authors： Taniguchi Y,Takahashi M,Matsudaira K,Oka H,Momose T

    更新日期：2016-11-01 00:00:00