Abstract：
:Chordomas are rare malignant bone tumours considered to arise from notochordal remnants that persist in the axial skeleton. Although their morphology can resemble that of a carcinoma, chondrosarcoma or malignant melanoma, the axial location and their well-defined immunophenotype, including expression of cytokeratins (CK7/20/8/18/19) and S100, generally allow the diagnosis to be made with confidence once the possibility is considered. In contrast, making a robust diagnosis of an extra-axial chordoma has been difficult in the absence of specific markers for chordomas. We have recently shown in gene expression microarray and immunohistochemistry studies that brachyury, a transcription factor crucial for notochordal development, is a specific and sensitive maker for chordomas. We now present a case of an intracortical tibial tumour, with detailed report of the imaging, and morphological features consistent with a chordoma, where notochordal differentiation was demonstrated with an antibody to brachyury. The tumour cells were also positive for cytokeratins, including CK19, and S100, CEA, EMA and HMBE1, findings which support the diagnosis of chordoma. Brachyury can be employed as a marker of notochordal differentiation and help identify confidently, for the first time, extra-axial bone and soft tissue chordomas, and tumours which may show focal notochordal differentiation.
journal_name
Skeletal Radioljournal_title
Skeletal radiologyauthors
O'donnell P,Tirabosco R,Vujovic S,Bartlett W,Briggs TW,Henderson S,Boshoff C,Flanagan AMdoi
10.1007/s00256-006-0167-4subject
Has Abstractpub_date
2007-01-01 00:00:00pages
59-65issue
1eissn
0364-2348issn
1432-2161journal_volume
36pub_type
杂志文章abstract：:Acute bone infarction is a well-described complication in sickle cell hemoglobinopathy but it is rarely reported in patients with thalassemia. This report describes an 18-year-old man with homozygous β-thalassemia presenting with a fever and severe acute bilateral ankle pain. The acute onset of severe pain and fever w...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-016-2387-6
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:MRI signal intensity of pediatric bone marrow can be difficult to interpret using conventional methods. Chemical shift imaging (CSI), which can quantitatively assess relative fat content, may improve the ability to accurately diagnose bone marrow abnormalities in children. METHODS:Consecutive pelvis and extr...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-016-2403-x
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Professional organizations recommend against repeat radiographs for routine follow-up of osteoarthrosis. However, clinics frequently obtain radiographs during or before the clinical visit. The purpose of our project was to determine the baseline frequency of unnecessary knee radiographs and whether education...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-019-03247-4
更新日期：2019-12-01 00:00:00
abstract：:Herniation of the left peroneus longus muscle was present in three male members of the same family, being the first reported case of this condition in a familial setting. The hernias were differentiated from other mass lesions and varices by magnetic resonance imaging. The images demonstrated a fascial defect originat...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00204860
更新日期：1995-11-01 00:00:00
abstract：:Radiologic examination of 43 patients revealed 47 lesions of a type which we have termed hemispherical spondylosclerosis (HSS). This term describes and includes the following essential and possible radiologic findings of the disease: 1) Hemispherical (or "dome-" or "helmet-shaped") sclerosis of the vertebra above the ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00347373
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVE:Osteoporosis is diagnosed based on the results of BMD assessment and/or fragility fractures. Vertebral fracture is the most common fragility fracture. Many vertebral fractures are asymptomatic and are not clinically recognized. Early detection of vertebral fracture may increase diagnosis of osteoporosis. In t...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-019-03280-3
更新日期：2020-02-01 00:00:00
abstract：:Osteomyelitis may pose as a diagnostic dilemma on various imaging modalities and may be confused with neoplasms and other pathology. Although a rare finding, extra-osseous fat fluid level, especially when associated with spongy bone destruction, can be considered a specific sign of osteomyelitis. Previously, only two ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-006-0194-1
更新日期：2007-06-01 00:00:00
abstract：:Osseous metastases to the hand and wrist are uncommon. Most cases represent the manifestation of known malignancy with disseminated disease. Less commonly, acrometastases are the initial presentation of malignancy. In both instances, diagnosis of malignancy is frequently not considered either clinically or radiographi...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00198077
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:A bone infarct may occasionally dedifferentiate to osteogenic sarcoma, fibrosarcoma or malignant fibrous histiocytoma. However, the association of an angiosarcoma with a bone infarct is extremely rare. Such an association is presented in three patients. Their clinical course is compared with that of patients ...
journal_title：Skeletal radiology
pub_type： 杂志文章,评审
doi：10.1007/s002560050435
更新日期：1998-10-01 00:00:00
abstract：:Though cranial hemangiomas are second only to vertebral hemangiomas in frequency, such lesions are rarely congenital and multiple. It is probable that the true incidence of congenital calvarial hemangiomas is higher than that reported in the literature, as they are unlikely to undergo imaging, most being asymptomatic ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-004-0891-6
更新日期：2005-08-01 00:00:00
abstract：:Primary synovial chondromatosis is rare in the foot. We report a case of synovial chondromatosis affecting multiple sites of the foot and causing bone erosions in a 44-year-old woman. Radiographs demonstrated erosions of multiple metatarsals including the tarsometatarsal joints, resulting in Lisfranc tarsometatarsal d...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-005-0923-x
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate retrospectively the safety and effectiveness of the computed tomography (CT) fluoroscopy-guided placement of iliosacral screws in patients with unstable posterior pelvic fractures. MATERIALS AND METHODS:Six patients (four women and two men; mean age 55.8 years; range...
journal_title：Skeletal radiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00256-009-0826-3
更新日期：2010-07-01 00:00:00
abstract：:A rare case of tuberculosis of the patella is presented. Diagnostic features include an osteolytic lesion in the patella with flaky sequestrum, associated with typical clinical features. Treatment should be urgent and should include a regimen of surgical debridement along with four antitubercular drugs. Once the joint...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s002560050334
更新日期：1998-01-01 00:00:00
abstract：:Chondroblastoma is a benign bone tumor that typically arises in the epiphysis of a long bone. However, when it occurs in non-epiphyseal location in flat bones, it may create a diagnostic problem. We describe such a case of chondroblastoma arising in the iliac bone. A 29-year-old man was incidentally found to have a bo...
journal_title：Skeletal radiology
pub_type： 杂志文章,评审
doi：10.1007/s00256-009-0833-4
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To determine the value of prebiopsy 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)/computed tomography (CT) in discriminating malignant from benign vertebral bone lesions. MATERIALS AND METHODS:This retrospective study included 53 patients with 55 vertebral bone lesions that underwent FDG-...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-020-03426-8
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To prospectively assess the evolution of postoperative MRI findings in asymptomatic patients after total hip arthroplasty (THA) over 24 months (mo). METHODS:This prospective cohort study included 9 asymptomatic patients (56.7 ± 15.0 years) after THA. Metal artifact-reduced 1.5-T MRI was performed at 3, 6, 12...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-020-03666-8
更新日期：2020-11-09 00:00:00
abstract：:A 23-year-old woman with a medical history significant for tuberous sclerosis presented with symptoms of postpartum endometritis. Focal gigantism of the third digit of her right hand was incidentally noted and is reported to be a rare manifestation of tuberous sclerosis. ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s002560050486
更新日期：1999-02-01 00:00:00
abstract：:This paper reports two giant-cell tumours of bone of low-grade malignancy, both complicated by the development of pulmonary metastases in which the histological appearances were identical to those of the primary neoplasm. Ten similar cases in the literature are reviewed. ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00357894
更新日期：1983-01-01 00:00:00
abstract：:We report the case of a 64-year-old man who initially presented with a maculopapular rash followed several weeks later by bilateral shin pain and infiltrative cutaneous lesions over the lower legs. The plain radiographs were not contributory, and the patient was referred for a whole-body bone scan, which demonstrated ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-009-0806-7
更新日期：2010-03-01 00:00:00
abstract：:There is still a paucity of information about the clinical presentation, treatment and imaging findings of latissimus muscle tears. Only one study has specifically described the magnetic resonance imaging (MRI) features of latissimus tendon tears. We describe a case of a high-grade tear in the latissimus muscle tendon...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-009-0717-7
更新日期：2009-11-01 00:00:00
abstract：:Diagnostic imaging is pivotal in the initial detection, characterization, staging and post-treatment follow-up of patients with high-grade osteogenic and Ewing's sarcoma. In the present review article, conventional and new imaging modalities are discussed with regard to the monitoring of the effect of neoadjuvant chem...
journal_title：Skeletal radiology
pub_type： 杂志文章,评审
doi：10.1007/s002560050339
更新日期：1998-02-01 00:00:00
abstract：:We conducted a radiographic survey of 117 competitive water ski jumpers to determine whether this sport can cause spinal column damage and, if so, whether damage is more likely to occur in those who participate during the period of spinal growth and development (age 15 years or younger). We found a high prevalence of ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00357108
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:To study the early change of bone matrix and soft tissue around articulation in adjuvant-induced arthritic (AIA) rats non-invasively by X-ray phase-contrast imaging (XPCI), a new imaging method. MATERIALS AND METHODS:Adjuvant-induced arthritis was established in male Sprague-Dawley (SD) rats (n=6, age 40 days)...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-005-0026-8
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to describe the elastographic appearance of the Achilles tendon in healthy subjects and patients with surgically repaired complete ruptures. MATERIALS AND METHODS:Nineteen Achilles tendons of 16 amateur footballers with surgically repaired complete ruptures and their contralatera...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-011-1339-4
更新日期：2012-09-01 00:00:00
abstract：:We report an extremely rare case of partial scapular duplication. Mild shoulder area deformity in a newborn prompted further evaluation that included radiography, ultrasonography and spiral CT. These revealed an additional bone in the area of the left shoulder, above the humerus and lateral to the scapula. The accesso...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-005-0936-5
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to use morphological as well as biochemical (T2 and T2* relaxation times and diffusion-weighted imaging (DWI)) magnetic resonance imaging (MRI) for the evaluation of healthy cartilage and cartilage repair tissue after matrix-associated autologous chondrocyte transplantation (MACT) of...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-009-0682-1
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVES:(1) To reveal the prevalence of the bony recess (posterior dimple) and (2) to determine the position of the posterior dimple on the tibial plateau using three-dimensional computed tomography (3DCT). MATERIALS AND METHODS:In this study, a retrospective review of 112 patients was performed to identify the pos...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-017-2625-6
更新日期：2017-08-01 00:00:00
abstract：:Bone density has been assessed during and after radiotherapy of metastases of the spine using quantitative computed tomography (QCT) in 19 patients with osteolytic vertebral lesions. All patients underwent external photon radiation with a total dose of 40 Gy over a period of 4 weeks. Measurements of vertebral mineral ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00351751
更新日期：1989-01-01 00:00:00
abstract：:A case of Petriellidium boydii (synonym: Allescheria boydii) infection of the knee joint is described. It followed a penetrating soft tissue injury with a pitchfork. Such infections are rare in this country and bone involvement has not been recorded previously except in maduramycosis contracted in tropical areas. ...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/BF00360494
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:Our study aims to compare the sensitivity and specificity between orthopaedic trainees and radiologists in diagnosing occult hip fractures from pelvic radiographs. METHODS:All patients undergoing computed tomography (CT) of the hip for a suspected occult hip fracture at our two centres between November 1, 20...
journal_title：Skeletal radiology
pub_type： 杂志文章
doi：10.1007/s00256-012-1472-8
更新日期：2013-02-01 00:00:00
