Abstract：
:Recent evidence supports the notion that the incidence of Cushing disease is higher than previously thought. Transphenoidal surgery, in the hands of experienced neurosurgeons, is currently considered the first-line treatment of choice. However, an examination of remission and recurrence rates in long-term follow-up studies reveals that potentially up to 40% to 50% of patients could require additional treatment. If left untreated, the resultant morbidity and mortality are high. Successful clinical management of patients with Cushing disease remains a challenge. The development of new therapeutic agents has been eagerly anticipated. This article discusses the results of currently available and promising new therapeutic agents used to treat this challenging disease.
journal_name
Neurosurg Clin N Amjournal_title
Neurosurgery clinics of North Americaauthors
Fleseriu Mdoi
10.1016/j.nec.2012.06.012subject
Has Abstractpub_date
2012-10-01 00:00:00pages
653-68issue
4eissn
1042-3680issn
1558-1349pii
S1042-3680(12)00087-3journal_volume
23pub_type
杂志文章,评审abstract：:The management of adult spinal deformity is characterized by significant variability in operative and nonoperative approaches. Adult spinal deformity encompasses a broad spectrum of disorders of the spine, and the disparity observed in reported clinical outcomes of operative and nonoperative care reflects the heteroge...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2007.03.002
更新日期：2007-04-01 00:00:00
abstract：:Lateral anterior column release (ACR) is a powerful extension of the minimally invasive lateral lumbar interbody fusion procedure that incorporates division of the anterior longitudinal ligament to allow manipulation of the anterior and middle spinal columns. The resulting surgical control permits restoration of signi...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2018.03.008
更新日期：2018-07-01 00:00:00
abstract：:Intracranial metastases are the single most costly neurologic ailment. This article provides the clinician with detailed statements of the patterns of their appearance and tumors of origin. Most common causative cancers are of lung, breast, or melanoma origin. Aggressive therapies carry with them the risk of nervous s...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：:This article defines open myelomeningocele and describes its development in the embryo. The anatomic features of the neural placode, pia-arachnoid, and dorsal versus ventral roots are well described. The surgical technique and prenatal and postnatal care are detailed. Anomalies associated with open myelomeningocele ar...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:During the last 10 years, gene therapy has certainly risen to the forefront of basic science and clinical medicine. Designing more efficient gene delivery systems is currently the "holy grail" of genetic therapeutics, because even the most efficient viral vectors do not transfect all cells at the treatment site, which...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-01 00:00:00
abstract：:The anatomy of the peripheral nervous system is presented, with special emphasis on the connective tissue sheaths and their relationship to the nerves' blood supply. The microanatomy of nerve fibers is also presented, with a focus on pathologic changes caused by compression and ischemic injuries. The article highlight...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:The spectrum of neurologic disease that complicates human immunodeficiency virus (HIV) is extremely broad. This article deals with those HIV-related diseases that may occur with a frequency of more than 1% and are of potential neurosurgical importance: those that result from a direct involvement of the nervous system ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Tentorial meningiomas are encountered relatively infrequently, but it is nonetheless important to be aware of their variable clinical presentations and the need for individualized preoperative assessment and surgical management. The challenges presented by these lesions are due in large part to the complexity and vari...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：:This article is an overview of the recent advances and cosmetic implications of various aspects of craniofacial surgery from a plastic surgical viewpoint. ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s1042-3680(02)00021-9
更新日期：2002-10-01 00:00:00
abstract：:Pituitary tumors manifest with a variety of unique localizing signs and symptoms that neurosurgeons and neuro-ophthalmologists must readily identify. Visual disturbances may be the presenting complaint. Loss of central visual acuity, visual field deficits, and mechanisms of diplopia are discussed with case examples us...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：:This article reviews the authors' experience with image-guided surgery for brain metastases and discusses specifically the impact of the frameless viewing wand system on standard craniotomy techniques for this disorder. Topics discussed include patient selection, interactive image-guided neurosurgical resection of bra...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:This article investigates the role of radiosurgery and stereotactic radiotherapy in the management of vestibular schwannomas (VS), reviewing the authors' own prospective cohort and the current literature. For patients with large Stage IV VS (according to the Koos classification), a combined approach with deliberate pa...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2013.06.002
更新日期：2013-10-01 00:00:00
abstract：:Anterior cervical discectomy and corpectomy for the treatment of cervical spondylosis,cervical disc herniation, and ossification of the posterior longitudinal ligament enjoy favorable rates of fusion and successful clinical outcomes. Although the complications from these procedures have been well described, the pathog...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2005.07.004
更新日期：2005-10-01 00:00:00
abstract：:Inadequate healing is an important mechanism for aneurysm development and recanalization after embolization. Matrix coils have been shown by experimental studies to enhance vascular repair and fibrosis, thus reducing the risk of recanalization. The clinical application of Matrix coils represents the transition from pu...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2005.03.001
更新日期：2005-07-01 00:00:00
abstract：:Psychosocial problems frequently are more difficult to manage than the seizures. Quality of life investigations are important in identifying psychosocial issues that impede the benefits of improved or complete seizure control. Three categories of quality of life assessment are discussed: professional observation and r...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1993-04-01 00:00:00
abstract：:The modern era of minimally invasive spine surgery has its roots in percutaneous techniques developed in the mid-twentieth century. The widespread application of minimally invasive techniques seen today is predicated on technologic developments of only the past 10 years, however. This article reviews the development o...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2006.06.007
更新日期：2006-10-01 00:00:00
abstract：:Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord impairment worldwide. Surgical intervention has been demonstrated to be effective and is becoming standard of care. Spine surgery, however, is costly and value needs to be demonstrated. This review serves to summarize the key health economic co...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2017.09.013
更新日期：2018-01-01 00:00:00
abstract：:Parkinson's disease (PD) affects more than 1 million people in the United States, which makes it one of the most common age-related neurodegenerative disorders, second only to Alzheimer disease. In light of this significant health problem, this review places emphasis on the exciting prospect of using stem cells as an ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2006.10.015
更新日期：2007-01-01 00:00:00
abstract：:Cranial dural arteriovenous fistulas (DAVFs) represent an important class of cranial vascular lesions. The clinical significance of these lesions is highly dependent on the pattern of venous drainage, with cortical venous reflux being an important marker of an aggressive, high-risk fistula. For asymptomatic benign fis...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2011.09.004
更新日期：2012-01-01 00:00:00
abstract：:Autopsy studies suggest that skull base metastases are likely underrecognized in patients with cancer. Patients frequently present with one or a combination of skull base clinical syndromes that manifest as pain or cranial neuropathy. Once a skull base metastasis is suspected, establishing a histologic diagnosis, dedi...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2020.06.013
更新日期：2020-10-01 00:00:00
abstract：:In this review, we focus on novel surgical techniques and spinal arthroplasty systems inactive development. First, we discuss systems that allow for minimally invasive approaches to the lumbar disc space: (1) lateral approaches, (2) posterior approaches,and (3) oblique approaches. These techniques offer the potential ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2005.08.001
更新日期：2005-10-01 00:00:00
abstract：:Skull base metastases (SBM) are rare among all tumors affecting the base of the skull. Because of their rarity, they have received limited attention in the published medical literature. Several clinical syndromes associated with SBM have been described. Knowledge of these syndromes and maintenance of a high index of s...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2010.08.005
更新日期：2011-01-01 00:00:00
abstract：:Acute toxicity from radiation of skull base tumors typically resolves spontaneously within days to weeks after completion of therapy. Long-term complications have a latency of months to years after radiation and are usually irreversible. The need to keep the probability of chronic toxicity at an acceptable level has d...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-01 00:00:00
abstract：:Arteriovenous malformations (AVMs) of the brain are vascular lesions in which an abnormal tangle or nidus of vessels permits pathologic shunting of blood flow from the arterial to the venous tree without an intervening capillary bed. With brain imaging techniques, an increasing number of AVMs are detected before they ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2009.07.004
更新日期：2009-10-01 00:00:00
abstract：:The human brain harbors stem cells in the subventricular zone (SVZ). The authors have collected postmortem and intraoperative tissue from adult human patients and found that it contains a unique ribbon of astrocytes that proliferate in vivo and can function as neural stem cells in vitro. Furthermore, they have conduct...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2006.10.013
更新日期：2007-01-01 00:00:00
abstract：:Aggressive surgical as well as medical management strategies have had limited success with improving outcomes from spontaneous intracerebral hematomas. Future prospects of treatment will undoubtedly focus on less invasive, better tolerated procedures to remove hematomas in select patients. Some success has been achiev...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1992-07-01 00:00:00
abstract：:With careful patient selection, timely neuroendovascular therapy can improve the clinical outcome of patients suffering from cerebrovascular ischemic disease. The current indications, techniques, recent experiences, limitations, and future directions of balloon angioplasty and local intra-arterial/intravenous thrombol...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Recently, endoscopic intraventricular surgery has been performed successfully in several clinical series. Although the therapeutic results must be compared with conventional surgery, neuroendoscopy seems to be a safe surgical technique when performed by surgeons with appropriate experience and refined endoscopic tools...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s1042-3680(03)00063-9
更新日期：2003-10-01 00:00:00
abstract：:Endovascular embolization is a frequently used adjunct to operative resection of meningiomas. Embolization may decrease intraoperative blood loss, operative time, and surgical difficulty associated with resection. The specific clinical applications of this treatment have not been defined clearly. Procedural indication...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2015.11.005
更新日期：2016-04-01 00:00:00
abstract：:This review provides historical and recent perspectives related to passive immunotherapy for high-grade gliomas. The authors discuss approaches that use lymphokine-activated killer cells, cytotoxic T lymphocytes, and monoclonal antibodies. ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2012.04.008
更新日期：2012-07-01 00:00:00
