Redefining Parkinson's disease research using induced pluripotent stem cells.

abstract：:Over the last few decades, the management of acute ischemic stroke has undergone significant advancements with the introduction of intravenous thrombolysis and more recently punctuated by the success of endovascular mechanical thrombectomy trials for large vessel occlusion. These advancements have transformed the prac...

journal_title：Current neurology and neuroscience reports

authors： Male S,Nickele C,Elijovich L

更新日期：2016-03-01 00:00:00

abstract：:Despite increases in our understanding of rabies pathogenesis, it remains an inevitably fatal disease. Lack of awareness, low level of political commitment to rabies control, and failure to recognize and correlate clinical, laboratory, and neuroimaging features contribute to continuing deaths. Clinical symptomatology,...

journal_title：Current neurology and neuroscience reports

authors： Hemachudha T,Wacharapluesadee S,Laothamatas J,Wilde H

更新日期：2006-11-01 00:00:00

abstract：:The management of carotid stenosis has enjoyed renewed interest in the neurological community in recent years due to the advent of endovascular approaches. In concert, progress in medical treatment of these patients has rekindled the debate regarding the best management of carotid stenosis overall, both for symptomati...

journal_title：Current neurology and neuroscience reports

authors： Marchidann A,Marshall RS

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarce data are present in literature about the predictive role of cerebrospinal fluid (CSF) bioma...

journal_title：Current neurology and neuroscience reports

authors： Liguori C,Paoletti FP,Placidi F,Ruffini R,Sancesario GM,Eusebi P,Mercuri NB,Parnetti L

更新日期：2019-01-14 00:00:00

abstract：PURPOSE OF REVIEW:Brain metastases are the most common intracranial tumors in adults. Historically, the median survival after the diagnosis of brain metastases has been dismal and medical therapies had a limited role in the management of these patients. RECENT FINDINGS:The advent of targeted therapy has ushered in an ...

journal_title：Current neurology and neuroscience reports

authors： Shonka N,Venur VA,Ahluwalia MS

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Measurements obtained during real-world activity by wearable motion sensors may contribute more naturalistic accounts of clinically meaningful changes in impairment, activity, and participation during neurologic rehabilitation, but obstacles persist. Here we review the basics of wearable sensors, the ...

journal_title：Current neurology and neuroscience reports

authors： Dobkin BH,Martinez C

更新日期：2018-10-06 00:00:00

abstract：PURPOSE OF REVIEW:To review the peripheral neurological complications of the acute hepatic porphyrias, as well as the latest advances in their pathophysiology and management. RECENT FINDINGS:The diagnosis of porphyric neuropathy remains challenging as varying neuropathic patterns are encountered depending on disease s...

journal_title：Current neurology and neuroscience reports

authors： Kazamel M,Desnick RJ,Quigley JG

更新日期：2020-10-07 00:00:00

abstract：:Accumulating evidence indicates a role for metabolic dysfunction in the pathogenesis of Alzheimer's disease (AD). It is widely reported that Type 2 diabetes (T2D) increases the risk of developing AD, and several postmortem analyses have found evidence of insulin resistance in the AD brain. Thus, insulin-based therapie...

journal_title：Current neurology and neuroscience reports

authors： Morris JK,Burns JM

更新日期：2012-10-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is the most common cause of acute paralysis, yet the pathogenesis has still not been fully elucidated and specific evidence-based consensus management guidelines have not been developed. This paper reviews the research of the past year dedicated to determining the pathogenesis of GBS, opt...

journal_title：Current neurology and neuroscience reports

authors： Green DM

更新日期：2002-11-01 00:00:00

abstract：:Hypersomnia includes a group of disorders in which the primary complaint is excessive daytime sleepiness. Chronic hypersomnia is characterized by at least 3 months of excessive sleepiness prior to diagnosis and may affect 4% to 6% of the population. The severity of daytime sleepiness needs to be quantified by subjecti...

journal_title：Current neurology and neuroscience reports

authors： Dauvilliers Y

更新日期：2006-03-01 00:00:00

abstract：:Since the advent of in vivo imaging, first with CT, and then MRI, structural neuroimaging in patients has been widely used as a tool to explore the neural correlates of a wide variety of cognitive functions. Findings from studies using this methodology have formed a core component of current accounts of cognition, but...

journal_title：Current neurology and neuroscience reports

authors： Malhotra PA,Russell C

更新日期：2015-08-01 00:00:00

abstract：:Tumefactive demyelinating lesions are rare consequences of central nervous system (CNS) idiopathic inflammatory demyelinating diseases. Tumefactive demyelinating lesions pose a diagnostic challenge because they can mimic tumors and abscesses and because they can be caused by a heterogeneous range of disorders. This ar...

journal_title：Current neurology and neuroscience reports

authors： Frederick MC,Cameron MH

更新日期：2016-03-01 00:00:00

abstract：:Iatrogenic fungal infections of the central nervous system had been considered a medical curiosity. Generally, they are a rare isolated complication of neurosurgical procedures, but periodically these infections are observed in larger populations as a result of exposure to contaminated materials during diagnostic or t...

journal_title：Current neurology and neuroscience reports

authors： Lahoti S,Berger JR

更新日期：2013-11-01 00:00:00

abstract：:A perilymph fistula is an abnormal connection between the inner and middle ear that allows escape of perilymph fluid into the middle ear compartment. The clinical symptomatology that follows leakage of fluid is by and large indistinguishable from a number of other pathologies that affect inner ear function. Definite d...

journal_title：Current neurology and neuroscience reports

authors： Maitland CG

更新日期：2001-09-01 00:00:00

abstract：:Over the past 10 years, the Food and Drug Administration has approved eight prophylactic antiepileptic drugs (AEDs). Although the goal of universal seizure control without side effects has not been reached, the tolerability of medications has improved. This paper reviews the AEDs introduced since 1993 and tries to obj...

journal_title：Current neurology and neuroscience reports

authors： Weinstein SL,Conry J

更新日期：2002-03-01 00:00:00

abstract：:Central nervous system (CNS) HIV-related disorders frequently have devastating consequences. Significant progress has been made in the early diagnosis and treatment of the HIV-infected patient. As a result, the prevalence and natural history of neurologic illnesses have changed. This paper reviews the epidemiology, cl...

journal_title：Current neurology and neuroscience reports

authors： Civitello L

更新日期：2003-03-01 00:00:00

abstract：:Dementia family caregiving has been the focus of research for decades. Much has been learned about the negative impact of caregiving as well as characteristics that may be protective. This paper explores themes in caregiving pertinent to clinicians and researchers working with dementia family caregivers: the psycholog...

journal_title：Current neurology and neuroscience reports

authors： Merrilees J

更新日期：2016-10-01 00:00:00

abstract：:Recent advances in the development and administration of chemotherapy for malignant diseases have led to prolonged survival of patients and the promise of a return to normal lives. The cost of progress comes with a price, however, and the nervous system is frequently the target of therapy-induced toxicity. Unlike more...

journal_title：Current neurology and neuroscience reports

authors： Malik B,Stillman M

更新日期：2008-01-01 00:00:00

abstract：:Stroke and especially its complications are a leading cause of death. Despite reduced morbidity in some developed countries, mortality in stroke patients is still high worldwide. In the past decades, treatment of acute stroke has focused on early intervention, such as revascularization and cerebral edema prevention. H...

journal_title：Current neurology and neuroscience reports

authors： Zhang S,He WB,Chen NH

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Research has consistently shown that type 2 diabetes (T2D) is associated with increased risk of all-cause dementia. Because one of the most common clinical presentations of early stage dementia is memory impairment, we examined the relationship of T2D with memory function, using the recently published...

journal_title：Current neurology and neuroscience reports

authors： Arvanitakis Z,Tatavarthy M,Bennett DA

更新日期：2020-11-05 00:00:00

abstract：:Sleep disorders are common in neurodegenerative diseases such as Parkinson's disease (PD), multiple system atrophy (MSA), amyotrophic lateral sclerosis (ALS), hereditary ataxias, and Alzheimer's disease (AD). Type, frequency, and severity of sleep disturbances vary depending on each of these diseases. Cell loss of the...

journal_title：Current neurology and neuroscience reports

authors： Gaig C,Iranzo A

更新日期：2012-04-01 00:00:00

abstract：:A decade after the US Food and Drug Administration (FDA) approved intravenous tissue plasminogen activator for treatment of acute ischemic stroke, the public health impact of this treatment on stroke outcome remains limited. The extremely small time window for treatment and very low recanalization rates in large arter...

journal_title：Current neurology and neuroscience reports

authors： Edgell R,Yavagal DR

更新日期：2006-11-01 00:00:00

abstract：:'Primary progressive aphasia' (PPA) refers to core linguistic disorders caused by neurodegenerative disease. Three main PPA variants are recognized: nonfluent/agrammatic, semantic and logopenic. Correctly classifying patients during life according to the underlying histopathology will become increasingly important as ...

journal_title：Current neurology and neuroscience reports

authors： Harris JM,Jones M

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Our purpose is to review evidence relating to the concept that interictal epileptiform discharges (IEDs) impair brain performance. RECENT FINDINGS:Sophisticated measures of motor and cognitive performance have clarified older observations, confirming that in both animals and humans, IEDs affect aspec...

journal_title：Current neurology and neuroscience reports

authors： Faught E,Karakis I,Drane DL

更新日期：2018-10-08 00:00:00

abstract：:Menstrual migraine and other hormonally related headaches are common in women. Falling estrogen levels or estrogen withdrawal after periods of sustained higher levels can trigger migraine. It makes sense to target this trigger for management of hormonally related headaches, particularly when nonhormonal strategies hav...

journal_title：Current neurology and neuroscience reports

authors： Shuster LT,Faubion SS,Sood R,Casey PM

更新日期：2011-04-01 00:00:00

abstract：:Despite the growing awareness of mild traumatic brain injury in military and civilian populations, understanding of the acute and chronic effects of concussion on central nervous system structure and function is limited. Even less is understood about the underpinnings of the cardinal postconcussive symptom, post-traum...

journal_title：Current neurology and neuroscience reports

authors： Monteith TS,Borsook D

更新日期：2014-02-01 00:00:00

abstract：:Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1...

journal_title：Current neurology and neuroscience reports

authors： Nagel MA,Gilden D

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The proportion to which genetic and environmental factors contribute to the etiology of multiple sclerosis (MS) is still incompletely understood. An interesting association between MS etiology and obesity has recently been shown although the mechanisms underlying this association are still unknown. We...

journal_title：Current neurology and neuroscience reports

authors： Huitema MJD,Schenk GJ

更新日期：2018-03-10 00:00:00

abstract：:Seizures represent an important clinical manifestation of inborn errors of metabolism. The presence of myoclonic seizures and very early onset are clues to a metabolic disorder. Specific correlations between age of seizure onset and electroencephalogram patterns with inborn errors of metabolism are discussed. The expl...

journal_title：Current neurology and neuroscience reports

authors： Pearl PL,Bennett HD,Khademian Z

更新日期：2005-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Although the immune system seems to play an important role in the pathogenesis of disease, target antigens are still uncertain and pathways leading to tissue destruction have not been fully elucidated. Recent stu...

journal_title：Current neurology and neuroscience reports

authors： Hemmer B,Kieseier B,Cepok S,Hartung HP

更新日期：2003-05-01 00:00:00