Abstract:
OBJECTIVE:Enhanced reactivity to substance related cues is a central characteristic of addiction and has been associated with increased activity in motivation, attention, and memory related brain circuits and with a higher probability of relapse. Modafinil was promising in the first clinical trials in cocaine dependence, and was able to reduce craving in addictive disorders. However, its mechanism of action remains to be elucidated. In this functional magnetic resonance imaging (fMRI) study therefore, cue reactivity in cocaine dependent patients was compared to cue reactivity in healthy controls (HCs) under modafinil and placebo conditions. METHODS:An fMRI cue reactivity study, with a double-blind, placebo-controlled cross-over challenge with a single dose of modafinil (200mg) was employed in 13 treatment seeking cocaine dependent patients and 16 HCs. RESULTS:In the placebo condition, watching cocaine-related pictures (versus neutral pictures) resulted in higher brain activation in the medial frontal cortex, anterior cingulate cortex, angular gyrus, left orbitofrontal cortex, and ventral tegmental area (VTA) in the cocaine dependent group compared to HCs. However, in the modafinil condition, no differences in brain activation patterns were found between cocaine dependent patients and HCs. Group interactions revealed decreased activity in the VTA and increased activity in the right ACC and putamen in the modafinil condition relative to the placebo condition in cocaine dependent patients, whereas such changes were not present in healthy controls. Decreases in self-reported craving when watching cocaine-related cues after modafinil administration compared to the placebo condition were associated with modafinil-induced increases in ACC and putamen activation. CONCLUSIONS:Enhanced cue reactivity in the cocaine dependent group compared to healthy controls was found in brain circuitries related to reward, motivation, and autobiographical memory processes. In cocaine dependent patients, these enhanced brain responses were attenuated by modafinil, mainly due to decreases in cue- reactivity in reward-related brain areas (VTA) and increases in cue reactivity in cognitive control areas (ACC). These modafinil-induced changes in brain activation in response to cocaine-related visual stimuli were associated with diminished self-reported craving. These findings imply that in cocaine dependent patients, modafinil, although mainly known as a cognitive enhancer, acts on both the motivational and the cognitive brain circuitry.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Goudriaan AE,Veltman DJ,van den Brink W,Dom G,Schmaal Ldoi
10.1016/j.addbeh.2012.04.006subject
Has Abstractpub_date
2013-02-01 00:00:00pages
1509-1517issue
2eissn
0306-4603issn
1873-6327pii
S0306-4603(12)00152-9journal_volume
38pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Age of onset is an important factor in the development and trajectory of psychiatric disorders; however, little is known regarding the age of onset in relation to disordered gambling in treatment seeking samples in the UK. Utilising a large residential treatment seeking gambler cohort, the current study exam...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2019.05.013
更新日期:2019-10-01 00:00:00
abstract::Smoking habits are continuously changing in the population. Cessation of smoking is not only often difficult but may lead to undesired consequences, esp. to weight gain. A random sample of 2283 persons with mild hypertension was followed up for 5 years in Eastern Finland and examined at the community-based cardiovascu...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/0306-4603(86)90002-x
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Research has shown that African Americans gain more than average weight after smoking cessation. However, African Americans have been underrepresented in post-cessation weight gain research. The current study examined 1) the pattern of weight gain and 2) the association between smoking status and weight ga...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2018.02.002
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Waterpipe use has increased dramatically in the Middle East and other parts of the world. Many users exhibit signs of dependence, including withdrawal and difficulty quitting, but there is no evidence base to guide cessation efforts. METHODS:We developed a behavioral cessation program for willing-to-quit wa...
journal_title:Addictive behaviors
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.addbeh.2014.02.012
更新日期:2014-06-01 00:00:00
abstract::The last few decades have seen increasing use of computer-based programmes to address illicit recreational drug use but knowledge about their effectiveness is limited. We conducted a systematic review to examine evidence on these programmes. Eight electronic databases were searched to identify primary research studies...
journal_title:Addictive behaviors
pub_type: 杂志文章,评审
doi:10.1016/j.addbeh.2013.09.010
更新日期:2014-01-01 00:00:00
abstract::Aftercare to prevent relapse following alcohol treatment has not received adequate experimental investigation. The present study monitored alcohol intake of 50 patients following assignment to either an intensive aftercare recruitment procedure or regular clinic aftercare. The results indicated that those who received...
journal_title:Addictive behaviors
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0306-4603(83)90056-4
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:The Brief Wisconsin Inventory of Smoking Dependence Motives (WISDM) is a multi-dimensional smoking dependence measure that assesses primary dependence motives (PDM; e.g., core dependence marked by tolerance, craving) and secondary dependence motives (SDM; e.g., auxiliary dependence motives such as cognitive ...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2014.11.017
更新日期:2015-04-01 00:00:00
abstract::Adverse childhood events may influence later behaviors, including adulthood substance use and social affiliation. Studies have noted high prevalence rates of adverse childhood experiences and adulthood substance abuse among homeless adults. Using an existing longitudinal, countywide probability sample of 397 homeless ...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2004.01.005
更新日期:2004-08-01 00:00:00
abstract::Treatment for drug use, like the process by which a person comes to use illicit drugs, may be seen to be at least in part a psychosocial process involving emotional, cognitive, and relationship domains. Treatment programs attempt to improve the psychosocial functioning of clients with the ultimate goal of effecting ch...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/0306-4603(95)00098-4
更新日期:1996-09-01 00:00:00
abstract::Cigarette smoking is a very important health problem and represents the largest preventable risk factor for premature death in developed countries. A considerable body of research indicates that impulsivity is a central etiological concept in many theoretical models of tobacco addiction. The aim of this study is to an...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2006.08.007
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Rates of substance use among adolescents have increased in the 1990s, however little is known about current patterns of substance use among youths entering adulthood. METHODS:We studied sex and age-specific rates of substance use (tobacco, alcohol, cannabis, other illicit drugs, inhalants and psychotropic m...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2007.09.009
更新日期:2008-01-01 00:00:00
abstract::This study was conducted to identify factors associated with alcohol use among early adolescents. A survey was administered to all Grade 7 and 8 students in 16 Vermont school districts. The questionnaire covered demographics, alcohol, tobacco, and marijuana use, and measures of psychosocial mediators of alcohol use dr...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2004.02.028
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Menthol, a flavoring compound added to cigarettes, makes cigarettes more appealing to youth and inexperienced smokers and increases cigarettes' abuse liability. However, limited studies are available on menthol's role in smoking progression. METHODS:To assess the association between menthol in cigarettes an...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2019.106045
更新日期:2019-11-01 00:00:00
abstract:AIM:We examined whether reciprocal relationships were present between the SURPS personality profiles and substance use in early adolescence. METHODS:Longitudinal data of four-waves of a broader effectiveness study were used from 1068 early adolescents. RESULTS:Our cross-lagged models indicated that sensation seeking ...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2013.08.003
更新日期:2013-12-01 00:00:00
abstract::In 2003 the Thai government announced a radical shift in drug policy with the implementation of a War on Drugs. Although consequences of this controversial measure (e.g. drug dealer deaths) have received widespread attention relatively little work has evaluated changes in substance use. We used two anonymous represent...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2006.12.002
更新日期:2007-08-01 00:00:00
abstract::Research on sexual orientation and substance use has established that lesbian, gay, and bisexual (LGB) individuals are more likely to smoke than heterosexuals. This analysis furthers the examination of smoking behaviors across sexual orientation groups by describing how same- and opposite-sex romantic attraction, and ...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2011.07.045
更新日期:2011-12-01 00:00:00
abstract::A short, reliable two-factor instrument measuring drinking-related negative consequences was developed from a previous measure using two samples of college students. In Study I, data on alcohol use and problems associated with alcohol use were collected on 382 introductory psychology students. The original College Alc...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/s0306-4603(00)00116-7
更新日期:2001-05-01 00:00:00
abstract::It has been proposed that internal, stable, and global attributions for the cause of a lapse following a period of abstinence and concomitant feelings of guilt and loss of control increased the probability of a return to regular substance use. The Abstinence Violation Effect (AVE) hypotheses were tested in a sample of...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/0306-4603(94)90048-5
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Electronic cigarettes (e-cigarettes) have gained popularity rapidly in the Western world but data in the East are scarce. We examined the awareness and ever use of e-cigarettes, and reasons for e-cigarette use in a probability sample of adults in Hong Kong. METHODS:Cross-sectional data were collected in 2...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2015.08.008
更新日期:2016-01-01 00:00:00
abstract::Patients with antisocial personality disorder in outpatient treatment for substance use disorders are at high risk of drop-out. Using a randomized design, this study tested the impact of adding a brief psycho-educational program, the Impulsive Lifestyle Counseling program, to outpatient substance abuse treatment in or...
journal_title:Addictive behaviors
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.addbeh.2016.02.001
更新日期:2016-06-01 00:00:00
abstract:INTRODCUTION:Recent epidemiological data has indicated an increasing trend in the non-medical use of prescription drugs (NMUPD) among college students. NMUPD has shown a strong relationship with heavy alcohol use and associated negative consequences. Despite the trends and association with other risky behavior, there r...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2014.10.027
更新日期:2015-04-01 00:00:00
abstract::This study assessed the effect of short-term (2-week) smoking abstinence on weight gain, energy intake, and physical activity in 60 postmenopausal women. Participants were stratified by their use of hormone replacement therapy (HRT; currently taking/not taking) and then randomized to abstinence or continued smoking fo...
journal_title:Addictive behaviors
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.addbeh.2004.02.041
更新日期:2004-07-01 00:00:00
abstract::Smoking reduces negative affect while it increases sympathetic nervous system activity. However, theories of emotion predict that increased autonomic arousal should increase rather than reduce negative affect. One explanation for this paradox is that nicotine interferes with perception of autonomic activity. We evalua...
journal_title:Addictive behaviors
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0306-4603(86)90061-4
更新日期:1986-01-01 00:00:00
abstract::Using a cover story of the effects of alcohol on perceptual and motor abilities, two levels of alcohol consumed (moderate and none), two levels of alcohol expectancy (moderate and none), and two levels of sensation seeking (high and low) were combined to determine their effect on risk taking in a driving simulator. Ni...
journal_title:Addictive behaviors
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0306-4603(89)90037-3
更新日期:1989-01-01 00:00:00
abstract::There is compelling evidence that college student athletes engage in frequent episodes of heavy drinking and are prone to negative consequences resulting from such use. This study sought to identify risk and protective factors associated with student-athlete drinking and determine if student-athlete risk factors diffe...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2008.07.010
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Heavy episodic drinking is common among college students and remains a serious public health issue. Previous event-level research among college students has examined behaviors and individual-level characteristics that drive consumption and related consequences but often ignores the social network of people w...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2017.12.030
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Vaping has become increasingly popular among youth and young adults in the last decade. At present, very little research has examined how vaping is associated with attitudes concerning the disapproval and perceived risk of using other substances. This paper examines the association between flavor-only vaping...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2019.106186
更新日期:2020-03-01 00:00:00
abstract::Tobacco use is prevalent in adolescents and understanding factors that contribute to smoking uptake remains a critical public health priority. While there is now good support for the role of implicit (preconscious) cognitive processing in accounting for changes in drug use, these models have not been applied to tobacc...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2007.11.008
更新日期:2008-05-01 00:00:00
abstract::A significant number of young, low-income women experiment with ecstasy outside of club or rave settings. The current study examined patterns and risk factors of ecstasy use among this group of women. A cross-sectional survey was conducted among 696 women aged 18 to 31 who sought gynecological care from two university...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2005.05.051
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Research investigating the unique impacts associated with engaging in nonmedical prescription opioid use (NMPOU) among males and females who also use illicit drugs is needed. METHODS:Data were collected between 2013 and 2017 from two linked prospective cohort studies in Vancouver: the At-Risk Youth Study an...
journal_title:Addictive behaviors
pub_type: 杂志文章
doi:10.1016/j.addbeh.2019.05.022
更新日期:2019-10-01 00:00:00