Abstract:
PURPOSE:The anterior cruciate ligament (ACL) is known to have a poor healing ability, especially in comparison with the medial collateral ligament (MCL) which can heal relatively well. Interleukin-1beta (IL-1β) is considered to be an important chemical mediator in the acute inflammatory phase of ligament injury. The role of IL-1β-induced expressions of lysyl oxidases (LOXs) and matrix metalloproteinases (MMPs), which respectively facilitate extracellular matrix (ECM) repair and degradation, is poorly understood. In this study, we aim to determine the intrinsic differences between ACL and MCL by characterising the differential expressions of LOXs and MMPs in response to IL-1β in the injury process. METHODS:Semi-quantitative polymerase chain reaction (PCR), quantitative real-time PCR, Western blot, and zymography were performed. RESULTS:We detected high expressions of IL-1β-induced LOXs in normal ACL and MCL. Then, we found IL-1β induced injured MCL to express more LOXs than injured ACL (up to 2.85-fold in LOX, 2.58-fold in LOXL-1, 1.89-fold in LOXL-2, 2.46-fold in LOXL-3 and 2.18-fold in LOXL-4). Meanwhile, we found IL-1β induced injured ACL to express more MMPs than injured MCL (up to 1.72-fold in MMP-1, 1.95-fold in MMP-2, 2.05-fold in MMP-3 and 2.3-fold in MMP-12). The further protein results coincided with gene expressions above. CONCLUSIONS:Lower expressions of LOXs and higher expressions of MMPs might help to explain the poor healing ability of ACL.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Xie J,Wang C,Yin L,Xu C,Zhang Y,Sung KLdoi
10.1007/s00264-012-1549-ysubject
Has Abstractpub_date
2013-03-01 00:00:00pages
495-505issue
3eissn
0341-2695issn
1432-5195journal_volume
37pub_type
杂志文章abstract::Over the last two centuries, treatment of hip pathology has evolved from joint excision and osteotomies to modern total hip arthroplasty (THA), which is considered one of the most successful surgical interventions ever developed. We here review the history of hip procedures that preceded Themistocles Glück. This evalu...
journal_title:International orthopaedics
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