Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats.

Abstract:

BACKGROUND/OBJECTIVE:Clinoptilolite is a natural zeolite crystal. Cytoprotective effects of clinoptilolite have been reported. However, so far there are no data about the effects of clinoptilolite treatment on oxidative stress after partial hepatectomy. In this experimental study, the effects of clinoptilolite treatment after partial hepatectomy on oxidative stress were evaluated. METHODS:There were four experimental groups (n=8): Group S, the sham group; Group H, the hepatectomy group; Group HC, the clinoptilolite treatment after partial hepatectomy group; and Group CS, the clinoptilolite-treated sham group. A 70% partial hepatectomy was performed for Group H and HC. Clinoptilolite (5mg/kg) was given to the rats orally (via gavage tube) twice a day for 10 days after hepatectomy. Malondialdehyde (MDA), Cu-Zn super oxide dismutase (SOD), and glutathione (GSH) levels were assessed to evaluate oxidative stress. RESULTS:Plasma and liver tissue MDA levels of Group HC were significantly lower than the H group (p=0.018 and p=0.000, respectively). Liver tissue Cu-Zn SOD activity and GSH levels of Group HC were significantly higher than Group H (p=0.003, p=0.007, respectively). CONCLUSION:Clinoptilolite administration reduces oxidant activity and supports antioxidant response after partial hepatectomy.

journal_name

Asian J Surg

journal_title

Asian journal of surgery

authors

Saribeyoglu K,Aytac E,Pekmezci S,Saygili S,Uzun H,Ozbay G,Aydin S,Seymen HO

doi

10.1016/j.asjsur.2011.11.007

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

153-7

issue

4

eissn

1015-9584

issn

0219-3108

pii

S1015-9584(11)00038-8

journal_volume

34

pub_type

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