Multifocality related factors in papillary thyroid carcinoma.

Abstract:

BACKGROUND:Papillary thyroid carcinoma (PTC) is the main type of the well-differentiated thyroid carcinomas. Multifocality is regarded as a poor prognostic factor for PTC. METHODS:Documents of 777 patients who underwent thyroidectomy were reviewed retrospectively. A total of 305 PTC patients were included. Patients with multifocal PTC were included in Group 1, and patients with unifocal PTC were included in Group 2. RESULTS:There were 165 patients (54.0%) in Group 1 and 140 patients (46%) in Group 2. The pathological mixed variant of PTC was significantly higher in Group 1 (p = 0,005). Lymph node metastasis (LNM) was detected at 9.6% and 3.5% in Group 1 and Group 2, respectively (p = 0,028). Micro PTC rates were 28.4% and 40.7% in Group 1 and Group 2, respectively (p = 0,017). Tumor size and pathologically mixed-type and fine-needle aspiration biopsy (FNAB) results were significantly different between multifocal and unifocal Micro PTC (p < 0.05). CONCLUSIONS:Multifocality is more frequent in patients with tumors ≥1 cm and mixed-type tumors. LNM is found more often in multifocal tumors. The presence of micropapillary tumors can be predicted preoperatively by ultrasound-guided FNAB. Mixed-type pathology is also a predictive factor for multifocality.

journal_name

Asian J Surg

journal_title

Asian journal of surgery

authors

Gur EO,Karaisli S,Haciyanli S,Kamer E,Genc H,Atahan K,Haciyanli M

doi

10.1016/j.asjsur.2018.05.004

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

297-302

issue

1

eissn

1015-9584

issn

0219-3108

pii

S1015-9584(18)30272-0

journal_volume

42

pub_type

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