New insights after the first 1000 liver transplantations at The University of Hong Kong.

Abstract:

BACKGROUND/OBJECTIVE:One thousand liver transplantations have been performed at the only liver transplant center in Hong Kong over a period of 22 years, which covered the formative period of living donor liver transplantation. These 1000 transplantations, which marked the journey of liver transplantation from development to maturation at the center, should be educational. This research was to study the experience and to reflect on the importance of technical innovations and case selection. METHODS:The first 1000 liver transplantations were studied. Key technical innovations and surgical therapeutics were described. Recipient survival including hospital mortality was analyzed. Recipient survival comparison was made for deceased donor liver transplantation and living donor liver transplantation indicated by hepatocellular carcinoma and other diseases. RESULTS:Among the 1000 transplantations, 418 used deceased donor grafts and 582 used living donor grafts. With the accumulation of experience, hospital mortality improved to < 2% in the past 2 years. In the treatment of diseases other than hepatocellular carcinoma, living donor liver transplantation was superior to deceased donor liver transplantation, with a 10-year recipient survival around 90%. CONCLUSION:Transplant outcomes have been improving consistently over the series, with a very low hospital mortality and a predictably high long-term survival.

journal_name

Asian J Surg

journal_title

Asian journal of surgery

authors

Chan SC,Cheung TT,Chan AC,Chok KS,Sharr WW,Fung JY,Liu CL,Fan ST,Lo CM

doi

10.1016/j.asjsur.2015.03.018

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

202-10

issue

4

eissn

1015-9584

issn

0219-3108

pii

S1015-9584(15)00065-2

journal_volume

39

pub_type

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