Abstract:
:The increased life expectancy of HIV-infected individuals due to improved treatment has revealed an unexpected increase in non-AIDS comorbidities that are typically associated with older age including cardiovascular disease, dementia and frailty. The majority of these diseases arise as the result of dysregulated systemic inflammation, and both the aged and HIV-infected individuals exhibit elevated basal levels of inflammation. In the elderly, increased inflammation and age-related diseases are associated with a state of impaired immunity called immunosenescence, which is thought to result from a lifetime of immune stimulation. It is now apparent that HIV induces premature immunosenescence within T-cells; however, the impact of HIV on aging of cells of the innate arm of the immune system is unknown. Innate immune cells play a central role in inflammation and are thus critical for the pathogenesis of inflammatory diseases. Limited evidence suggests HIV infection mimics age-related changes to innate immune cells; however, the extent of this effect and the mechanism underlying these changes remain to be defined. This review focuses on the impact of HIV infection on the function and aging of innate immune cells and discusses potential drivers of premature immunosenescence including chronic endotoxaemia, residual viraemia, telomere attrition and altered cellular signalling.
journal_name
Sex Healthjournal_title
Sexual healthauthors
Hearps AC,Angelovich TA,Jaworowski A,Mills J,Landay AL,Crowe SMdoi
10.1071/SH11028subject
Has Abstractpub_date
2011-12-01 00:00:00pages
453-64issue
4eissn
1448-5028issn
1449-8987pii
SH11028journal_volume
8pub_type
杂志文章,评审相关文献
Sexual Health文献大全abstract:BACKGROUND:The NSW Sexual Health Infoline (SHIL) is a free and confidential sexual health information and referral line. The ability of Australian sexual health helplines to facilitate successful referrals has not been studied. In the present study, we sought to determine whether callers were successful in accessing th...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH13106
更新日期:2013-12-01 00:00:00
abstract::Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a serious public health problem, compromising the management and control of gonorrhoea globally. Resistance in N. gonorrhoeae to ceftriaxone, the last option for first-line empirical monotherapy of gonorrhoea, has been reported from many countries globally, an...
journal_title:Sexual health
pub_type: 杂志文章,评审
doi:10.1071/SH19023
更新日期:2019-09-01 00:00:00
abstract::A 44-year-old man with well-controlled HIV presented with low-grade fever, pharyngitis, frontal headache, abdominal and shin pain, and abnormal liver function tests 8 weeks after switching from zidovudine to abacavir (while continuing nevirapine and lamivudine). An abacavir reaction was the working diagnosis and thus ...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH12187
更新日期:2013-07-01 00:00:00
abstract:UNLABELLED:Background The aim of this pilot study was to assess the feasibility, acceptability and effectiveness of Positive Outlook, an online self-management program for gay men living with HIV in Australia. METHODS:Two pilot studies were conducted, a small feasibility study (Pilot 1) followed by a pilot randomised ...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH15064
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Drug use has been associated with risk behaviour among gay men. We examined the use of drugs and sexual risk behaviour among homosexually-active men who engaged in group sex in Australia. METHODS:We used an anonymous, self-complete survey about participants' most recent occasion of group sex with other men ...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH09014
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:To describe trends in HIV diagnoses among men who have sex with men (MSM) in New Zealand 1996-2008, and to identify characteristics associated with HIV diagnoses in the resurgent phase. METHODS:Data collected through routine surveillance of HIV infection, where the mode of transmission included homosexual c...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH10087
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:This study explored the role of masculinity and perceived condom use skills in African-American men's abusive response to female partners' condom requests. METHODS:Eighty African-American men aged 18-29 years completed measures on sexual behaviour, responses to condom requests, condom use self-efficacy and ...
journal_title:Sexual health
pub_type: 信件
doi:10.1071/SH13011
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:China has seen a proliferation of entertainment centres that are frequented by business people. Employees at these centres often are young, female rural-to-urban migrants who may be vulnerable to sexual violence and exploitation. METHODS:Data for this study were collected using a self-administered survey am...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH13044
更新日期:2013-11-01 00:00:00
abstract::The present study describes complex drug and sexual risk in a group of male sex workers (n = 79) who were recruited in the context of a larger study of young heroin users in Hanoi, Vietnam (n = 1270). Male sex workers were significantly more likely than male non-sex workers to be migrants (P < 0.001) and to have unsta...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/sh07018
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:This multi-method study explores the perceived health status and health behaviours of sexual minority (i.e. self-identifying with a sexual identity label other than heterosexual) females (i.e. those assigned female at birth who may or may not identify as women) in Mumbai, India, a population whose health has...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH17042
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:A vaccine program is underway to protect women against human papillomavirus (HPV) and thus cervical cancer. Previous studies have reported very low levels of HPV knowledge and there has been concern that preventative vaccines might not be readily accepted, given that HPV is transmitted sexually and the optim...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/sh07023
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Several studies have examined condom use during 'holiday' sex but have not considered condom errors in this context. This study aims to identify factors associated with late application of condoms during participants' most recent vaginal intercourse at home and away from home (holidays or short breaks). MET...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH13079
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:An understanding of vaccine acceptance and uptake is imperative for successful vaccination of populations that will be primary targets for vaccination after a vaccine against HIV is developed and ready for dissemination. Experiences with vaccination against vaccine-preventable hepatitis (VPH) among men who h...
journal_title:Sexual health
pub_type: 杂志文章,评审
doi:10.1071/sh06069
更新日期:2007-06-01 00:00:00
abstract:UNLABELLED:Background Men and women with HIV infection are at increased risk of developing cancers associated with human papillomavirus (HPV). The two licensed prophylactic HPV vaccines protect against de novo infection with HPV-16 and HPV-18, which cause the majority of HPV-associated cancers. Currently, no vaccine ef...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH14015
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:There is evidence that anal sex is becoming increasingly popular among heterosexual women and men. Several studies carried out in especially vulnerable populations (e.g. sex workers and low-income youth) suggested that anal sex may indicate a more general propensity to sexual risk-taking. METHODS:To assess ...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH10078
更新日期:2011-09-01 00:00:00
abstract::Nucleic acid detection tests (NADT) have considerable benefits for the detection of Neisseria gonorrhoeae (GC), including high sensitivity across a range of specimen types and use under widely differing settings and conditions. However, sexual health practitioners and others who use data generated by NADT for GC shoul...
journal_title:Sexual health
pub_type: 杂志文章,评审
doi:10.1071/sh07050
更新日期:2008-03-01 00:00:00
abstract::Background A 2006 Australian sexual health clinic audit of pelvic inflammatory disease (PID) diagnosis rates found variability between doctors. Doctors were given audit feedback towards increasing diagnosis and reducing variability. The clinic implemented other improvements to increase capacity. This study investigate...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH18119
更新日期:2019-06-01 00:00:00
abstract::Background Strategic communications are critical for successful market introduction of oral pre-exposure prophylaxis (PrEP). This paper focuses on the OPTIONS Consortium's approach to developing the PrEP Communications Accelerator, a digital tool that provides communication strategies and tools for generating demand f...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH18064
更新日期:2018-11-01 00:00:00
abstract:UNLABELLED:Objective To compare condom use motives and behaviours in the context of penile-vaginal intercourse (PVI) with new versus established sexual partners, using daily event-level data among a clinic-recruited sample. METHODS:Participants (ages 15-65 years old) were recruited from five sexually transmissible inf...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH13159
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Australia has a widely dispersed network of public sexual health services that test large numbers of people from high prevalence populations for genital Chlamydia trachomatis infection. These populations include young sexually active heterosexuals, men who have sex with men, sex workers and Aboriginal and To...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH09125
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Research indicates that the incidence of hepatitis C (HCV) among HIV-positive men who have sex with men (MSM) is increasing. Although injecting drug use remains the predominant means of transmission of HCV in the developed world, there is evidence of sexual transmission of HCV among MSM. Stigma associated wi...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH12179
更新日期:2013-07-01 00:00:00
abstract::porA pseudogene-negative Neisseria gonorrhoeae isolates produce false-negative results when examined by polymerase chain reaction (PCR) with porA pseudogene targets. In the present study, 533 representative gonococcal isolates received in 2011 via the Gonococcal Resistance to Antimicrobials Surveillance Program were e...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH16162
更新日期:2017-08-01 00:00:00
abstract::Background:One of the possible negative consequences of sexting is the non-consensual sharing of received-intimate content. This study aimed to determine the characteristics and motives of youths who shared received-intimate images without consent. Methods: Data were obtained from a self-administrated Swiss survey on ...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH19201
更新日期:2020-06-29 00:00:00
abstract:OBJECTIVE:To develop guidelines to facilitate management of HIV infection as a chronic disease within the setting of a sexual health or other HIV outpatient clinic. METHODS:We undertook a literature search to identify published guidelines and expert panel commentaries on screening and managing non-AIDS comorbidities i...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH10021
更新日期:2011-03-01 00:00:00
abstract::Background Clinical guidelines recommend annual chlamydia tests for all sexually active people aged 15-29 years. This study measured adherence to these guidelines and compared testing rates to the projected levels required to reduce chlamydia prevalence. METHODS:All chlamydia tests conducted in Tasmania during 2012-1...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH16146
更新日期:2017-11-01 00:00:00
abstract::Rates of sexually transmissible infections (STIs) in remote central Australian Aboriginal communities have been persistently high for over two decades, yet risk factors for STIs in these communities are not well understood. This qualitative study explored behavioural and contextual risk factors for STIs in young Abori...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH19181
更新日期:2020-04-01 00:00:00
abstract::Background Forced migration is associated with sexual vulnerability. However, little is known about the sexual health literacy and needs of refugee-background youth post resettlement. METHODS:Conducted in partnership with the Queensland Sudanese community, this study used a cross-sectional survey to explore the sexua...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH16171
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To describe prisoners' sexual experiences and sexual practices while in the community, sexual identities, and sexual health (e.g. self-reported exposure to sexually transmissible infections (STIs) and female reproductive outcomes) using data from the Sexual Health and Attitudes of Australian Prisoners (SHAAP)...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH12104
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:This study examined the prevalence, correlates and consequences of abnormal Pap smears in a population-based survey of sexuality and health in the Australian community. METHODS:Cross-sectional telephone survey of 908 women aged 18-59 years randomly selected from the Commonwealth electoral roll. RESULTS:Mos...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/sh05044
更新日期:2006-12-01 00:00:00
abstract::Background Syphilis incidence worldwide has rebounded since 2000, particularly among men who have sex with men (MSM). A predictive model for syphilis infection may inform prevention counselling and use of chemoprophylaxis. METHODS:Data from a longitudinal cohort study of MSM and transgender women meeting high-risk cr...
journal_title:Sexual health
pub_type: 杂志文章
doi:10.1071/SH17118
更新日期:2018-06-01 00:00:00