Abstract:
:Nucleic acid detection tests (NADT) have considerable benefits for the detection of Neisseria gonorrhoeae (GC), including high sensitivity across a range of specimen types and use under widely differing settings and conditions. However, sexual health practitioners and others who use data generated by NADT for GC should be aware of some important limitations of these tests. False-positive results caused by cross reaction with commensal Neisseria species have been observed in many assays, and have lead to unacceptably low positive-predictive values in some patient populations. Further, false-negative results can be caused by GC sequence variation, with some gonococci lacking certain NADT target sequences. This review examines the issues associated with gonococcal NADT and considers best practice for use of these assays based on current knowledge. We emphasise the need for supplementary testing and extensive assay validation, and suggest appropriate strategies for these requirements irrespective of the setting in which they are used. Further, we highlight the need to maintain culture-based testing for certain specimen sites as well as for antimicrobial resistance surveillance.
journal_name
Sex Healthjournal_title
Sexual healthauthors
Whiley DM,Garland SM,Harnett G,Lum G,Smith DW,Tabrizi SN,Sloots TP,Tapsall JWdoi
10.1071/sh07050subject
Has Abstractpub_date
2008-03-01 00:00:00pages
17-23issue
1eissn
1448-5028issn
1449-8987pii
SH07050journal_volume
5pub_type
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