Towards personalized therapy for patients with glioblastoma.


:Combined therapy with temozolomide and radiotherapy is a standard treatment and improves the survival for patients with newly diagnosed glioblastoma. However, the prognosis remains poor, with a median survival time of 12-15 months. Currently, several clinical trials of dose-dense temozolomide regimen or molecular-targeting therapies have been performed to overcome the resistance of glioblastoma. In these therapies, rational prognostic biomarkers have also been investigated to predict their outcome and response to treatment. This advanced understanding of the biological markers can help to develop personalized therapies for glioblastoma patients. Generally, due to a reduced tolerance, elderly patients do not seem to benefit from intensive treatment. This population needs individual treatments depended on their age or performance status. In this article, we review the recent studies that can provide personalized therapy for glioblastoma, based on molecular tumor profiling or patients' physical status.


Shirai K,Chakravarti A




Has Abstract


2011-12-01 00:00:00












  • Breath testing as a method for detecting lung cancer.

    abstract::Early diagnosis of lung cancer is important due to high mortality in late stages of the disease. An ideal approach for population screening could be the breath analysis, due to its non-invasiveness, simplicity and cheapness. Using sensitive methods of analysis like gas chromatography/mass spectrometry in exhaled air o...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


    authors: Taivans I,Bukovskis M,Strazda G,Jurka N

    更新日期:2013-12-13 00:00:00

  • Sentinel lymph node biopsy for melanoma of the head and neck.

    abstract::Since its first description nearly two centuries ago, melanoma has been a difficult disease to diagnose and treat. With the incidence and mortality rates slowly increasing, understanding this disease is more important than ever. Herein, the current diagnostic and treatment recommendations for melanoma of the head and ...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Lentsch EJ,McMasters KM

    更新日期:2003-10-01 00:00:00

  • Clinical implications of body composition assessment by computed tomography in metastatic renal cell carcinoma.

    abstract::According to computed tomography image analysis, skeletal muscle (SM) and adipose tissue areas vary widely in patients with the same body mass index or the same body surface area. Body composition variables such as SM mass, SM density and subcutaneous and visceral adipose tissue have shown value as potential independe...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Antoun S,Lanoy E,Albiges-Sauvin L,Escudier B

    更新日期:2014-03-01 00:00:00

  • An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland.

    abstract::Introduction: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. Areas covered: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature rev...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Vartanian JG,Gonçalves Filho J,Kowalski LP,Shah JP,Suárez C,Rinaldo A,De Bree R,Rodrigo JP,Hamoir M,Takes RP,Mäkitie AA,Zbären P,Andreasen S,Poorten VV,Sanabria A,Hellquist H,Robbins KT,Bödeker CC,Silver C,Ferlito A

    更新日期:2019-10-01 00:00:00

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    abstract::B cells play an important role in the pathogenesis of certain lymphomas and leukemias, as well as many autoimmune diseases. Antagonistic B-cell antibodies are thus gaining an increasing role in the management of these diseases. The first antibody target in this regard was CD20, with the development and introduction of...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Goldenberg DM

    更新日期:2006-10-01 00:00:00

  • Clinical and epidemiologic burden of chronic myelogenous leukemia.

    abstract::Chronic myelogenous leukemia represents 7-20% of all leukemia cases, with a worldwide incidence projected at less than one to two per 100,000 people. Approximately 85% of patients are diagnosed with chronic-phase chronic myelogenous leukemia and up to 40% are asymptomatic. Treatment strategies include chemotherapy, in...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Redaelli A,Bell C,Casagrande J,Stephens J,Botteman M,Laskin B,Pashos C

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    abstract::Although available targeted therapies provide some clinical efficacy, a need remains for antiangiogenic therapies with alternative mechanisms in order to provide better outcomes and the ability to circumvent resistance. Inhibition of multiple VEGF targets may produce enhanced efficacy and more durable responses throug...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


    authors: Gordon MS

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  • Current surgical treatment of intermediate risk differentiated thyroid cancer: a systematic review.

    abstract::Introduction: Surgical treatment of thyroid cancer has become less aggressive but for many patients, the threshold for performing total thyroidectomy (TT), as opposed to thyroid lobectomy (TL), has remained unclear. Current American Thyroid Association (ATA) guidelines encourage more individualization of treatment opt...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Wade M,Seigne JD

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Prestwich RJ,Harrington KJ,Pandha HS,Vile RG,Melcher AA,Errington F

    更新日期:2008-10-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


    authors: Feld J,Belasen A,Navada SC

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Tsao CK,Gartrell BA,Oh WK,Galsky MD

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    更新日期:2018-04-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Puglisi S,Perotti P,Cosentini D,Roca E,Basile V,Berruti A,Terzolo M

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Galluzzo P,Bocchetta M

    更新日期:2011-04-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


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    更新日期:2006-03-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Orlando KA,Nguyen V,Raab JR,Walhart T,Weissman BE

    更新日期:2019-05-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Guarneri V,Barbieri E,Dieci MV,Piacentini F,Conte P

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    pub_type: 杂志文章


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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


    authors: Rimassa L,Santoro A

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  • Screening for ovarian cancer.

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Lewis S,Menon U

    更新日期:2003-02-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 社论


    authors: Olowokure O,Qi X

    更新日期:2014-05-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Mayr NA,Huang Z,Sohn JW,Lo SS,Teh BS,Lu JJ,Grecula JC,Kunos C

    更新日期:2011-07-01 00:00:00

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    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章


    authors: González J,Gaynor JJ,Ciancio G

    更新日期:2021-01-29 00:00:00

  • New drug therapies for advanced renal cell carcinoma.

    abstract::The incidence of renal cell cancer is increasing and surgery is the only curative treatment for patients presenting with localized disease at diagnosis. The treatment of metastatic renal cell cancer is palliative and, until recently, immunotherapy has been the standard treatment approach with response rates between 10...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Gore ME,Harrison ML,Montes A

    更新日期:2007-01-01 00:00:00

  • Sequencing therapy in advanced prostate cancer: focus on sipuleucel-T.

    abstract::Immunotherapies such as sipuleucel-T present new and unique challenges for the optimal timing and sequencing of therapies for metastatic castration-resistant prostate cancer (mCRPC). Key considerations for the sequencing of sipuleucel-T are its unique proposed mechanism of action, the time required to generate a clini...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Quinn DI,Vaishampayan U,Higano CS,Lin DW,Shore ND,Beer TM

    更新日期:2014-01-01 00:00:00

  • Metastatic soft tissue sarcoma: current treatment landscape and future perspectives.

    abstract:INTRODUCTION:The therapeutic armamentarium for advanced soft tissue sarcoma (STS) has increased over the last few years. Doxorubicin monotherapy or in combination is now the established first line treatment. Beyond first line treatment, no standard therapy has been established. Novel drugs have reached the late-clinica...

    journal_title:Expert review of anticancer therapy

    pub_type: 杂志文章,评审


    authors: Skafida E,Kokkali S,Nikolaou M,Digklia A

    更新日期:2017-06-01 00:00:00