Abstract:
:Since its first description nearly two centuries ago, melanoma has been a difficult disease to diagnose and treat. With the incidence and mortality rates slowly increasing, understanding this disease is more important than ever. Herein, the current diagnostic and treatment recommendations for melanoma of the head and neck are reviewed, with special emphasis on the use of sentinel lymph node biopsy (SLNB). For the past decade, SLNB has been a well-accepted procedure in the treatment of truncal and extremity melanoma, providing useful information for both treatment and prognosis. Still, despite its clear role in the rest of the body, the role of SLNB has not yet been fully defined in the management of melanoma of the head and neck. The complexity of lymphatic drainage patterns and the frequent need to remove sentinel lymph nodes from the parotid gland, thus placing the facial nerve at risk, have made head and neck surgical oncologists slow to adopt this method. However, current data from several trials indicate that in the head and neck, sentinel lymph nodes can be identified reliably approximately 98% of the time using intraoperative lymphatic mapping. In addition, the false-negative and complication rates are appropriately low. SLNB allows for accurate staging of patients, informed discussions of prognosis and the use of adjuvant therapies, including radiation and interferon-alpha2b. For these reasons, the authors believe that SLNB will become the standard-of-care for head and neck melanoma as well as for other body sites.
journal_name
Expert Rev Anticancer Therjournal_title
Expert review of anticancer therapyauthors
Lentsch EJ,McMasters KMdoi
10.1586/14737140.3.5.673keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
673-83issue
5eissn
1473-7140issn
1744-8328pii
ERA030510journal_volume
3pub_type
杂志文章,评审abstract::Dietary factors and other naturally occurring substances may emerge as potent therapeutic or preventative agents in the battle against prostate cancer. Much of the current support for these agents is epidemiologically based, but new prospective studies are now underway which may support their use in conventional medic...
journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/14737140.3.2.203
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abstract::There is increasing interest in the use of prognostic markers that may predict survival and guide management in patients diagnosed with the early stages of chronic lymphocytic leukemia (CLL). Currently, the most important traditional prognostic factors include clinical staging, lymphocyte doubling time and β2-microglo...
journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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更新日期:2021-01-28 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2011-07-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2012-05-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-05-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/14737140.7.9.1193
更新日期:2007-09-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Expert review of anticancer therapy
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doi:10.1080/14737140.2021.1852934
更新日期:2020-12-13 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Expert review of anticancer therapy
pub_type: 社论
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更新日期:2015-01-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/era.12.99
更新日期:2012-09-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 社论
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/14737140.8.7.1159
更新日期:2008-07-01 00:00:00