Abstract:
BACKGROUND:We aimed to evaluate the incidence of acute toxicity in a 3-week accelerated radiation therapy (RT) schedule with a concomitant boost compared with the 6.5-week conventional schedule with a sequential boost for early-stage, node-negative breast cancer. MATERIALS AND METHODS:This study included the first 50 patients treated on protocol using the accelerated schedule as well as 74 patients with comparable stages of disease treated over the same period using the conventional schedule. An accelerated schedule of 40.5 Gy × 2.7 Gy/fraction to the whole breast with 4.5 Gy × 0.3 Gy/fraction concomitant boost, for a delivered total dose of 45.0 Gy × 3.0 Gy/fraction in 15 fractions to the lumpectomy site. The conventional schedule used 46.8 Gy × 1.8 Gy to the whole breast with a sequential boost of 14.0 Gy × 2.0 Gy/fraction, delivering a total dose of 60.8 Gy × 33 fractions to the lumpectomy site. The side effects observed during RT and through the initial 8 weeks after treatment were scored for acute toxicity. RESULTS:A lower incidence of ≥ grade 2 skin toxicity was observed among patients treated on the accelerated schedule compared with those treated on the conventional schedule (p = .0015). There was a higher incidence of breast pain among patients receiving the conventional schedule (p = .045). No significant difference in the incidence of breast edema, fatigue, or hematologic side effects was observed between the 2 groups. CONCLUSION:Our observations suggest that there is acceptable toxicity with the accelerated schedule as used in this study. Further, it is not associated with a higher risk of acute toxicity when compared with the conventional schedule. Patients in the study are being followed, and clinical outcomes will be reported as the data mature.
journal_name
Clin Breast Cancerjournal_title
Clinical breast cancerauthors
Chadha M,Vongtama D,Friedmann P,Parris C,Boolbol SK,Woode R,Harrison LBdoi
10.1016/j.clbc.2011.09.002subject
Has Abstractpub_date
2012-02-01 00:00:00pages
57-62issue
1eissn
1526-8209issn
1938-0666pii
S1526-8209(11)00199-6journal_volume
12pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Based on preclinical studies and a phase I trial of the combination of bortezomib and pegylated liposomal doxorubicin (PLD), which both showed activity in breast cancer, we conducted a phase II study of this regimen in patients with metastatic breast cancer. PATIENTS AND METHODS:Patients received bortezomib...
journal_title:Clinical breast cancer
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abstract:INTRODUCTION:Axillary lymph node dissection (ALND) is currently the recommended procedure in patients with tumor-positive sentinel lymph node biopsy (SLNB). A significant proportion of patients with positive SLNs will not have any additional metastases in nonsentinel lymph nodes (NSLNs). Predictive nomograms could iden...
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
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pub_type: 杂志文章,多中心研究
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
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doi:10.1016/j.clbc.2014.09.012
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
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pub_type: 杂志文章
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journal_title:Clinical breast cancer
pub_type: 杂志文章,随机对照试验
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journal_title:Clinical breast cancer
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