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BRCA mutations and the risk of angiosarcoma after breast cancer treatment.

Abstract：

:Post-breast cancer treatment-related angiosarcomas were first observed in lymphedematous extremities after mastectomy and are now being reported with increasing frequency after lumpectomy and radiation. A case history is presented of a BRCA2 carrier who had a postmastectomy chest wall angiosarcoma but had neither therapeutic radiation nor clinically evident lymphedema. The absence of established risk factors led to speculation that the BRCA2 germline mutation could be a causative factor in the development of this patient's angiosarcoma. A literature review supported this concept.

journal_name

Clin Breast Cancer

journal_title

Clinical breast cancer

authors

West JG,Weitzel JN,Tao ML,Carpenter M,West JE,Fanning C

doi

10.3816/CBC.2008.n.066

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

533-7

issue

6

eissn

1526-8209

issn

1938-0666

pii

S1526-8209(11)70817-5

journal_volume

8

pub_type

杂志文章

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